Check out our latest preprint from the lab!!

Hedging their bets: how bacterial pathogens diversify to survive infection Phenotypic heterogeneity within isogenic bacterial populations represents a fundamental adaptation strategy that enables pathogen survival across the …

New review out! Bacterial pathogens diversify to survive during infection - using bet-hedging and division of labor to generate specialized subpopulations. We explore how host signal actively drive this process

www.sciencedirect.com/science/arti...

RNA Splicing Lab - JOIN US Are you interested in investigating basic mechanisms in splicing regulation and gene expression? Our research group was launched in September 2024 and is hosted at the Institute of Molecular Infection...

We have an open position for a #PhD student (last week to apply!) & a lab technician/TA. For more information see: www.beuschlab.org/join-us
Interested in understanding post-transcriptional regulation and how #RNA #splicing decisions are made? Then take a look or share with people who might be! 🧪🧫

We are looking for RNA enthusiasts to join us at the @uniregensburg.bsky.social as a junior group leader! Our university offer excellent infrastructure and collaboration opportunities for ground breaking RNA research. Please RT @jrrnascientists.bsky.social @rnasociety.bsky.social

Unraveling posttranscriptional regulatory networks in phage infection Phages employ sophisticated transcriptional regulatory networks to optimize replication. Recently, Silverman et al. used RIL-seq (RNA interaction by l…

Like bacteria, phages use sRNAs to regulate gene expression! Out today in @cp-trendsmicrobiol.bsky.social, @mvelascogomariz.bsky.social and I highlight a recent RIL-seq study from the @saharmelamed.bsky.social lab that looked into posttranscriptional regulation of lambda!

tinyurl.com/lambda-RIL-seq

Unraveling posttranscriptional regulatory networks in phage infection

SNIPE is a widespread bacterial defence system that exploits the spatial organization of phage genome injection to specifically target viral DNA, distinguishing self from non-self in prokaryotic immune systems @nature.com @mitpress.bsky.social
www.nature.com/articles/s41...

A pore-forming antiphage defence is activated by oligomeric phage proteins - Nature Bacteria use diverse defence systems against phages, including a 164-residue prophage-encoded protein, Rip1, which senses conserved phage assembly rings to form membrane pores that block virion maturation and trigger premature host cell death.

Nature research paper: A pore-forming antiphage defence is activated by oligomeric phage proteins

go.nature.com/4rA3cmd

Pre-assembly of biomolecular condensate seeds drives RSV replication - Nature Viral ribonucleoprotein–viral protein networks form pre-replication centres that nucleate viral factories and drive respiratory syncytial virus replication.

Nature research paper: Pre-assembly of biomolecular condensate seeds drives RSV replication

go.nature.com/3NIdNNn

Construction of complex and diverse DNA sequences using DNA three-way junctions - Nature Sidewinder enables high-fidelity DNA assembly by separating the information that guides assembly from the final assembled sequence.

Nature research paper: Construction of complex and diverse DNA sequences using DNA three-way junctions

go.nature.com/4qu2ExZ

Photo: HIRI / Luisa Härtig

Hooray! 🎉 We are celebrating Shazeb Ahmad from Redmond Smyth's laboratory, who defended his doctoral dissertation today. Congratulations on this remarkable achievement, @shazebahmad.bsky.social! Read more: www.helmholtz-hiri.de/en/newsroom/...

Visualizing the transcription and replication of influenza A viral RNAs in cells by multiple direct RNA padlock probing and in situ sequencing (mudRapp-seq) Abstract. Influenza A viruses (IAVs) contain eight negative-sense single-stranded viral RNA (vRNA) molecules, which are transcribed into messenger RNA (mRN

Excited to share my first-author publication from my #PhD work at @helmholtz-hiri.bsky.social 🎉

We established mudRapp-seq, a spatial transcriptomic technique that combines direct RNA padlock probing and in-situ sequencing.

academic.oup.com/nar/article/...

A positive-sense single-stranded RNA virus acquired a negative-sense open reading frame through recombination Author summary The discovery of brine shrimp virga-like virus 1 (BSVV1) challenges the conventional view that positive- and negative-sense RNA viruses are evolutionarily independent. Through genomic a...

Recombination between positive-sense and negative-sense RNA viruses: journals.plos.org/plospathogen...

Transcriptomic profiling of individual bacteria by MATQ-seq - Nature Protocols Bacterial single-cell sequencing via MATQ-seq combines index sorting, random priming and rRNA depletion, and offers high cell retention and transcript capture rates, making it ideal for experiments wi...

If you want to do single-cell RNA-seq on your favourite bacterium, here‘s our detailed Nature Protocol for microbial MATQ-seq. It profiles up to 600 genes in a single bacterial cell!

www.nature.com/articles/s41...

Phage coexistence, even when you least expect it.

Check out @norapyenson.bsky.social's study showing the repeated assembly of diverse phage communities: www.science.org/doi/10.1126/...

Also Nora's bsky thread here: bsky.app/profile/nora...

#SocialViruses #virosky #evosky 🧪🦠