HaDeX2: multi-dimensional analysis of Hydrogen-Deuterium Exchange Mass Spectrometry data https://pubmed.ncbi.nlm.nih.gov/41838411/

If you want to learn more about HaDeX2, listen to Weronika's webinar at hdxms.net/2025Software... (kindly organized by the International Society of HDX-MS).

This work won't happen without our fantastic collaborators: Krystyna Grzesiak, Dominik Rafacz, Michał Kistowski, @jhsmit.bsky.social, Julien Marcoux and Michał Dadlez as well our amazing funding agency @ncn.gov.pl

Thanks to the diligent work of Weronika Puchała
@werpuc
, once again we can offer a web server (with an improved user experience) at hadex2.mslab-ibb.pl and R package for high-throughput analysis (github.com/hadexversum/...)

We are extra proud about the charts: all of them are linked to underlying data to increase their FAIRness. Moreover, we introduce structural visualisation for high-resolution deuterium uptake and if HaDeX2 is too limited for your taste, export your data to Chimera or HDXViewer!

Functionality-wise, we should have everything you need and more: from novel quality control methods (inspect variability across charge states or replicates), through statistical analysis (also with high-resolution weighted averaging approach) to publication-grade charts

HaDeX2, a comprehensive web server and R package for analysis of #HDXMS data is published by
#bioinformatics
- check the manuscript to see the most important changes: academic.oup.com/bioinformati...

Thank you for promoting our grant! @msca-onetick.bsky.social explores tick-borne diseases through a #onehealth paradigm, linking human, animal, and environmental factors like #climatechange!

I want to thank all co-authors, especially Aleksandra Kalitnik and @annalassota.bsky.social. This is the second work related to our AmyloGraph 2.0 project, where we map the landscape of amyloid-amyloid interactions.

Our review of experimental methods to study #amyloid-amyloid interactions is finally here: onlinelibrary.wiley.com/doi/10.1002/.... We present a set of experimental strategies to comprehensively describe the dynamic and often elusive interactions between amyloid proteins.

This is such a fantastic project!

AmyloGraph AmyloGraph version: 0.5.2. Last built: 2023-06-08.

This project was led by Valentín Iglesias
and Jarosław Chilimoniuk, with great contributions from
Carlos Pintado-Grima, Oriol Bárcenas and
Salvador Ventura. Also, this is the first publication leading to the new version of the AmyloGraph database (amylograph.com) 3/3

I was personally shocked to see how many great resources are available there and how unique information they provide. Seeing that CPAD 2.0 (web.iitm.ac.in/bioinfo2/cpad2) already collects information on the experimental conditions of aggregation experiments was genuinely shocking! 2/3

Summary of active amyloid databases.

Curious about the scope of data resources available on #amyloid aggregation? Our review provides a comprehensive overview (doi.org/10.1016/j.cs...), and all details are on our dedicated site: biogenies.info/amyloid-data.... Check it out to explore the landscape of amyloid data! 1/3