Omega-3 linked to faster cognitive decline in a new cohort study:
psych-partners.com/new-risk-wit...
Can't prove causation, but study is well designed and supports a little-known finding from randomized trials - higher doses (above 1,500 mg) may worsen cognition.
#psychiatry #pmhnp #neurology
Warning: This study ranks all meds for #bipolar through a network meta-analysis, a method prone to error.
But it can highlight some overlooked options, like
▪ Asenapine (Saphris)
▪ Carbamazepine
Do you find any new gems in the pile:
psych-partners.com/the-best-pre...
#psychiatry #pmhnp
We don’t know that risk, since it didn’t show up in controlled trials but did in some case reports. They recommend slow titration raising by 15 min/wk and using 12-2 pm to reduce risk
Yes this surprised me. And needs replication
Does anyone remember Vayarin for #ADHD?
This FDA-cleared supplement fell out of production in 2019, but its ingredients (omega-3 and phosphatidylserine) keep appearing in trials, like this new one:
psych-partners.com/phosphatidyl...
Evidence is low, but better for the combo than either alone.
Meds don't treat #autism 's core symptoms, but #TMS brings hope in new trial:
psych-partners.com/tms-in-autis...
Earlier studies were mixed, but this used fMRI to direct magnet more accurately, targeting the fronto-parietal network with iTBS.
#psychiatry #pmhnp #autismawareness
New study of compulsive gambling on antipsychotics in psychosis:
▪ Most common on aripiprazole (4.5%)
▪ Close to rate of pramipexole in #depression (1-3%)
But it varies by population, and gambling is just the half of this hedonic syndrome. Lear more:
psych-partners.com/aripiprazole...
#psychiatry
Does mirtazapine treat anxiety?
▪ Yes for GAD and anxious #depression.
▪ Possibly for other #anxiety disorders.
▪ No for social anxiety.
From a new meta-analysis:
psych-partners.com/mirtazapine-...
#psychiatry #pmhnp #mentalhealth
Social Rhythm #Therapy (IPSRT) is a top approach for #bipolar, and this trial tested it in a new form, led by a team of nurses and bringing wisdom from this nurse-psychoanalyst.
Can you guess who she is? Find out:
psych-partners.com/therapy-ipsr...
#psychiatry #pmhnp #bipolardisorder #psychology
How to address insomnia in #alcohol use disorder?
This new study modified CBT-insomnia #therapy for #sleep and substance use. Learn the key steps:
psych-partners.com/cbti-alcohol
You'll find more research summaries on the new DailyPsych blog:
psych-partners.com/category/res...
#psychiatry #pmhnp
Do GLP-1 agonists like #Ozempic treat #depression?
This analysis of non-psychiatric trials suggests they improve well-being a little, but not depressive symptoms, an interesting distinction:
psych-partners.com/glp-1-agonis...
#psychiatry #pmhnp
This 23 year study arrives at a surprising conclusion:
▪ Low conscientiousness is not just a risk factor but a necessary link to developing problematic drinking
But this trait has benefits as well. Learn how to guide people to the positive side:
psych-partners.com/personality-...
#sobriety
Flow is an at-home tDCS device newly approved for depression.
But does it work when antidepressants do not? A new analysis finds a small positive signal, but it's brief and doesn't last:
psych-partners.com/tdcs-for-tre...
#psychiatry #pmhnp
A few meds might keep #ketamine and #esketamine from working in #depression:
▪ Lamotrigine
▪ Lithium
▪ Benzos
This new study compares them, finding that only the benzo blunted response:
psych-partners.com/benzodiazepi...
Limitation: Not randomized, but supported by other trials and basic science.
Surprisingly, Bipolar II carries a 62% higher mortality rate than #Bipolar I in new study.
Get the details, and learn which mood stabilizers extend the lifespan:
psych-partners.com/bipolarii-ri...
#psychiatry #pmhnp
Inflammation contributes to 30% of depressions, and 50% of treatment-resistant cases.
New review clarifies how #stress, trauma, and modern life trigger this immune reaction, pointing to lifestyle approaches that reduce #inflammation and improve mood:
psych-partners.com/modern-life-...
#Autism looks different in girls and women:
▪ Less repetitive behaviors like flapping
▪ Their restricted interests are more socially acceptable
▪ More masking (camouflaging)
New review identifies two instruments to improve the diagnosis, in links here:
psych-partners.com/autism-looks...
#therapy
Light therapy for addictions?
▪ No clinical trials
▪ But addresses some of the pathophysiology of addiction
▪ Treats comorbidities: Depression, bipolar, PTSD, insomnia, circadian disruption ("night owl"), and more
What's your experience with it? Full review:
psych-partners.com/light-therap...
Atomoxetine may not be first-line in #ADHD, but we can make it work better.
This is one of few drugs the FDA has warned about gene-interactions, and a new study points the way to safer dosing:
psych-partners.com/why-atomoxet...
#psychiatry #pmhnp #ADHDAwareness
Wake up!
That's the call of a surprising finding on AI Scribes:
▪ They document more details on mental health
▪ But clinicians are less likely to intervene on those details when mental health problems arise
Why? Read more and tell me your guess...
psych-partners.com/ai-scribes-d...
Did the FDA just approve a new antipsychotic without a single clinical trial?
Find out what makes Bysanti not-so-different:
psych-partners.com/milsaperidon...
#psychiatry #pmhnp #bipolar #schizophrenia
The secret is out:
▪ A newly approved antipsychotic is identical to one that is about to go generic.
Read this before the next Vanda rep stops by:
psych-partners.com/milsaperidon...
#psychiatry #pmhnp #schizophrenia #bipolar #medicine
Medications don't treat anorexia, but zinc might, and #CBD improved weight in this first placebo controlled trial:
▪ Small, barely positive
▪ Has a theoretical basis
Full details:
psych-partners.com/cbd-for-anor...
#psychiatry #pmhnp #eatingdisorder
New study clarifies risks of antipsychotics in pregnancy (for psychotic disorders):
▪ 60% higher risk of relapse if stopped during pregnancy
▪ Antipsychotics are not teratogenic, but some raise risk of gestational diabetes
More guidance:
psych-partners.com/pregnancy-an...
#pmhnp #obgyn
SSRIs and SNRIs double the bleeding risk in vulnerable patients, and a new tool helps you decide when to take action:
psych-partners.com/ssris-bleedi...
▪ Risk higher with NSAIDs/anticoagulants
▪ Proton pump inhibitors lower risk of GI bleeds
▪ Bupropion/mirtazapine = low-risk alternatives
TBS is a magnetic therapy like TMS, but delivered over a few minutes/day.
It (barely) treated geriatric #depression in new trial.
Evidence grade high 9/10, with blind intact.
TMS has favorable data in elderly and vascular depression. Get the full details:
psych-partners.com/tbs-late-lif...
I try to post solid findings here, but this one is not.
It's a call for more research on something that affects a lot of patients:
▪ Premenstrual worsening of #ADHD
A few new papers are out, summarized here. It's a start:
psych-partners.com/adhd-menstru...
#ADHDAwareness #WomensHealth
Highlights from new industry-sponsored review of daridorexant:
▪ Improves next day functioning, may reduce fall risk, like other orexins
▪ Safety in elderly and sleep apnea
▪ Cross-taper from older meds gradually (1-2 mth)
More detail & practice tips:
psych-partners.com/daridorexant...
#psychiatry
Probiotics failed in the first randomized trial to test them for substance-induced #depression.
Full details of this small study are here, along with supplements that have a role in substance use disorders:
psych-partners.com/probiotics-f...
#addiction #therapy #pmhnp #psychiatry #naturalhealth
Do diabetes meds protect kidneys on #lithium?
Li-renal function improved on SGLT2 Inhibitors in new cohort study (they are known to protect the kidneys)
Evidence grade: Low (4/10) cohort study
NAC is another possibility; details at:
psych-partners.com/protecting-t...
#psychiatry #pmhnp