The image shows vascular malformations surrounded by reactive astrocytes. Collagen IV labels endothelial basement membrane (blue/cyan), GFAP marks reactive astrocytes (green), and VEGFA ( red).

Loss of angiopoietin-2 leads to region-specific brain malformations and blood-brain barrier leakage

Angiopoietin 2 promotes vascular permeability in peripheral organs, but its role in brain is unclear.

doi.org/10.1172/jci....
Li et al. show ANGPT2 loss in mice leads to region-specific brain malformations and blood-brain barrier leakage.

Pediatric long COVID is characterized by myeloid CCR6 suppression and immune dysregulation

Reporting on a biomarker that distinguishes long COVID from controls in kids
doi.org/10.1172/jci....

Izquierdo-Pujol et al. immunoprofiled long COVID in kids, finding overactive immunity & weak COVID antibodies link to long COVID and myeloid CCR6 as a biomarker with 79% accuracy.

🧒🦠 What drives #LongCOVID in children?

Our new @IrsiCaixa research in JCI Insight reveals:
🔹 Immune dysregulation
🔹 Reduced neutralizing antibodies
🔹 CCR6 as a potential biomarker (79% accuracy)

👉 A key step toward better diagnosis & treatments

🔗 doi.org/10.1172/jci....

#Pediatrics #Immunology

Behind the Scenes: First author Minu-Tshyeto K. Bidzimou presents this work during his dissertation defense.

How does the most common cause of Alternating Hemiplegia of Childhood lead to abnormal repolarization and arrhythmogenesis? doi.org/10.1172/jci....

@andrewlandstrom.bsky.social & team propose a Ca2+-mediated mechanism in ATP1A3-D801N carriers & identify NCX1 as a possible target.

Challenging the idea that psoriasis is solely a skin disease

doi.org/10.1172/jci....
ASCI member James G. Krueger & team reveal a strong inflammatory signature in cutaneous adipose tissue of patients with psoriasis, amplified by obesity & partially dependent on IL-17 signaling.

We’re honored to be on the cover of @insight.jci.org this month! This work uncovers a key role for sympathetic nerve-CAF interactions in driving PDAC progression and remodeling the TME.

"Single-cell mapping of human endometrium and decidua reveals epithelial and stromal contributions to fertility" by Burns et al. insight.jci.org/articles/vie...

Uterine Gene Expression May Hold the Secret to Fertility | The Scientist Single-cell RNA sequencing of endometrial samples across the menstrual cycle identified key cell types and gene signatures that influence embryo implantation.

Here is a nice feature of JCI Insight, Burns et al. in The Scientist: www.the-scientist.com/uterine-gene...

Cancer-associated fibroblasts (CAFs) closely surround sympathetic nerve fibers in pancreatic tumors, observed in both human and mouse tissues.

Behind the scenes: PI Dr. Ece Eksi and PhD student Ariana Sattler examine tissue sections from sympathetically denervated mice, where loss of nerve signaling is associated with reduced pancreatic tumor growth.

Identifying a potential therapeutic vulnerability in pancreatic cancer: doi.org/10.1172/jci....

Featured on the Cover, @eksiece.bsky.social et al. report sympathetic nerve-fibroblast crosstalk drives nerve injury, fibroblast activation & matrix remodeling in pancreatic cancer.

Very happy this work is now out on its final format!

We showed that the combination of fentanyl and alcohol leads to severe apnea that is not rescued by naloxone.

From bench to breakthrough: Muneer Lab team, united and standing together in pursuit of scientific discovery.

Presenting a strategy to reduce alcohol-induced neurovascular damage

Saikia et al. treated alcohol-exposed mice with a peptide for enhancing Nrf2 activity, revealing its role in boosting antioxidant defenses, reducing BBB damage & leukocyte migration: doi.org/10.1172/jci....

Study provides answers to progressive heart problems in muscular dystrophy and potential reversibility This better understanding of heart problems in muscular dystrophy underscores the importance of early monitoring, early treatment and sex differences of cardiac symptoms.

T. Cooper, R-C Hu et al provide answers to progressive #heartProblems in #muscularDystrophy and potential reversibility. #DM1 #DMPKgene #MBNLproteins @insight.jci.org @bcmhouston.bsky.social blogs.bcm.edu/2026/04/03/f...

Potentiation of fentanyl-induced respiratory depression by alcohol is not fully reversed by naloxone: doi.org/10.1172/jci....

Fentanyl and alcohol are often a fatal combination

Here, @renatamarchette.bsky.social & team show overdoses from the combination in a rat model leads to severe apnea that is not fully rescued by naloxone: doi.org/10.1172/jci....

ICYMI: Metastasis is the leading cause of breast cancer mortality.

Here, William J. Muller & team find the STAT3-induced cytokine CHI3L1 recruits neutrophils that break extracellular matrix barriers and enable cancer spread, using mouse models: doi.org/10.1172/jci....

IFN-γ–induced trained immunity enhances killing of priority pathogens in healthy and genetically vulnerable individuals: doi.org/10.1172/jci....

Introducing an IFN-γ–mediated strategy for enhancing immunity

Sharee A. Basdeo & team report immune cells that defend against early infection can be trained to better fight tuberculosis and MRSA, especially in vulnerable individuals: doi.org/10.1172/jci....

Targeting PI3Kγ anchoring enhances CFTR membrane localization and modulator efficacy via PKD1

Offering a strategy to enhance the efficacy cystic fibrosis therapies

In this Research Article, Alessandra Ghigo & team report on a peptide targeting PI3Kγ that boosts airway CFTR membrane localization in cells derived from patients with cystic fibrosis: doi.org/10.1172/jci....

Research Letter: Consideration of spatial companion biomarkers for targeted therapeutics in cancer: depatuxizumab mafodotin in glioblastoma

Lukas et al. use multi-protein tissue imaging to demonstrate EGFR expression heterogeneity within GFAP+ GBM: doi.org/10.1172/jci....

Endothelial oncogenic KRAS mutation drives the dynamics of microglia and macrophages in brain arteriovenous malformation

There are no medications for reducing rupture risk of brain arteriovenous malformations

Park et al. find a role for microglia & macrophages in the destabilization of bAVMs, reporting that minocycline treatment in mice limited intracerebral hemorrhages: doi.org/10.1172/jci....

Macrophages expressing macrophage receptor with collagen structure attenuate liver fibrosis through a tissue restoration phenotype