Researchers are unlocking the healing powers of... poop Scientists have discovered that gut-born bacteria may hold the secret for treatments of everything from IBD to Parkinson’s disease. Now they just need samples from the people living in the most isolat...

Poop plays a much bigger role in health than most people realize. 🧫
A National Geographic deep dive on how gut microbes shape health, and what happens when diversity disappears.
www.nationalgeographic.com/science/arti...
#microbiome #science

Waste not: how researchers harness pee and poo for science It might seem gross, but these materials are treasure troves for research.

Grateful to see the GMbC featured in Nature! 🌍🧬
The article highlights our mission, community partnerships, and how we turn everyday waste into meaningful science.
Huge thanks to everyone who makes this work possible. www.nature.com/articles/d41...

Host transcriptional responses to gut microbiome variation arising from urbanism Gut microbiomes of urban communities are compositionally different from their rural counterparts, and are associated with immune dysregulation and gastrointestinal disease. However, it is unknown whet...

... and the other one that discovers that shifts in the gut microbiome linked to urbanization impact host gene expression (in collaboration with @blekhman.bsky.social & @fluca2406.bsky.social):

www.biorxiv.org/content/10.1...

This work is accompanied by two other studies, one showing that industrialization drives convergent microbial and physiological shifts in the human metaorganism:

www.biorxiv.org/content/10.1...

These findings show that gut bacteria are not passive passengers — they are actively evolving with their human hosts, mirroring the ecological pressures of their industrialized or non-industrialized host environments.

... as well as: within- and between-species convergent positive selection in key functions; within- and between-species convergent allelic variants in stress-response, cell-envelope, and metabolic genes

Across species of Bacteroides, Parabacteroides, and Blautia, strains from industrialized hosts show: larger proteomes, associated with recent increases in gene transfer and more fluid pangenomes...

Isolate genomes revealed richer functional content and mobile genetic elements than paired MAGs from the same hosts and species, allowing us to detect fine-scale evolutionary changes.

We built a collection of 6,000 cultured gut bacterial genomes from 9 countries included in the GMbC cohort, and compared their evolution across host lifestyles.

Convergent genomic responses of human gut bacteria to variations in industrialization To what extent gut bacteria respond to the distinct ecological pressures imposed by human lifestyle remains unclear. Here, we investigate how genomic adaptation in gut bacteria differ between industri...

Do gut bacteria evolve differently in industrialized vs. non-industrialized humans?
Our new study reveals that industrialization drives parallel genomic adaptations across gut bacterial species worldwide:

www.biorxiv.org/content/10.1...

#microbiome #globalhealth #GMbC #genome #evolution

Host transcriptional responses to gut microbiome variation arising from urbanism Gut microbiomes of urban communities are compositionally different from their rural counterparts, and are associated with immune dysregulation and gastrointestinal disease. However, it is unknown whet...

... and the other one that discovers that shifts in the gut microbiome linked to urbanization impact host gene expression (in collaboration with @blekhman.bsky.social & @fluca2406.bsky.social):

www.biorxiv.org/content/10.1...

Convergent genomic responses of human gut bacteria to variations in industrialization To what extent gut bacteria respond to the distinct ecological pressures imposed by human lifestyle remains unclear. Here, we investigate how genomic adaptation in gut bacteria differ between industri...

This work is accompanied by 2 other studies, one showing that industrialization drives parallel genomic adaptations in gut bacteria:

www.biorxiv.org/content/10.1...

Our results highlight the need for globally inclusive microbiome research to ensure discoveries translate across all human populations.

These shifts occur independently of other determinants of the microbiome, such as host genetics, geography, and diet.
Microbiome-based disease models trained on industrialized populations also fail to generalize globally.

We uncover convergent microbial and immune responses to industrialized lifestyles - specifically a loss of microbial diversity, the homogenization of gut communities, reduced community stability, elevated gut stress markers and increased IgA secretion, and altered immune-microbe interactions

Generating new data from >1,000 participants across 12 countries and 35 localities worldwide, we combined gut metagenomics, host genotyping, IgA-seq, lifestyle, diet, and biomarkers to build a multidimensional picture of the human metaorganism — the host and its gut microbiome together.

How does industrialization and lifestyle impact our interactions with gut microbiomes? And what is the consequence of these perturbations on our physiology?
Discover findings from our new study addressing these questions:

www.biorxiv.org/content/10.1...

#microbiome #globalhealth #GMbC

Gut microbiota profiles of peninsular Malaysian populations are associated with urbanization and lifestyle - Scientific Reports Scientific Reports - Gut microbiota profiles of peninsular Malaysian populations are associated with urbanization and lifestyle

New publication from the Global Microbiome Conservancy @mmmicrobiomelab.bsky.social!
Leveraging our dataset from Peninsular Malaysia, we report a clear stratification of microbial community structure, diversity and composition, along the rural–urban gradient.
www.nature.com/articles/s41...

Fermented foods affect the seasonal stability of gut bacteria in an Indian rural population - Nature Communications Here, the authors profile the gut microbiota and metabolites of Indian agrarians to understand the impact of fermented foods consumption, and identify seasonal variation in the gut microbiota structur...

#microbiome

"Here we showed that seasonal shifts between the Prevotella- and Bifidobacterium/Ruminococcus-driven community types, or ecological states [...] particularly in fermented milk consumers." in Indian agrarian individuals.

www.nature.com/articles/s41...

How citizen scientists and community engagement boost the impact of health research With the Declaration of Helsinki now mandating community engagement, Nature Medicine asks three winners of the Nature Awards for Inclusive Health Research to share their tips.

With the Declaration of Helsinki now mandating community engagement, Nature Medicine asks three winners of the Nature Awards for Inclusive Health Research to share their tips. #Medsky 🧪

Check out our work on Antarctic innate immune systems:

eur03.safelinks.protection.outlook.com?url=https%3A...