FEBS Press This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial-to-mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP-binding pa....

What if the extracellular matrix actively reprograms TGFβ signaling to drive metastasis?

Our new study reveals that the COMP–PMEPA1 axis promotes EMT and shifts signaling toward pSMAD1/5 in breast cancer cells.

🔗 doi.org/10.1002/1878...
#BreastCancer #EMT #CancerBiology #TumorMicroenvironment

There's a month left for you to submit an abstract or apply for a Travel Grant to attend the next edition of Defence is the Best Attack, taking place in Barcelona in May! ☀️

Join us for an overview of the most recent advances in the field of immunotherapy:

eacr.org/conference/d...

Submit your abstract and apply for a Travel Grant to attend Persister Cells 2025!

Taking place in Lyon, this conference will delve into molecular mechanisms, therapeutic targets and emerging clinical implications of cancer persister cells.

eacr.org/conference/p...

FEBS Press Traditionally, adipocytes have been viewed as energy storage units, which upregulate inflammatory factors in response to obesity. However, emerging evidence demonstrates that adipocytes are highly re...

Just recently I wrote an opinion piece with Shingo Kajimura, based around the idea that adipocytes, besides having energy storage/endocrine function, also act as immune hubs #Immunosky 🧪

1/🧵

febs.onlinelibrary.wiley.com/doi/10.1111/...

Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts - Nature Microbiology Coffee consumption is associated with the presence and abundance of a specific member of the human gut microbiome, Lawsonibacter asaccharolyticus, and changes to the plasma metabolome.

I love this kind of science go.nature.com/4i3gqUI

Meet our PhD student Rebecca! This year, she beat cancer AND published her first 1st-author paper on how hypoxia induces complement signaling in GBM, alters macrophage polarization, and how the C3-C3AR1 axis can be therapeutically targeted in GBM models. Check it out! insight.jci.org/articles/vie...

Adipose tissue retains an epigenetic memory of obesity after weight loss - Nature Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...

Nooooooo 😱 www.nature.com/articles/s41...

Differential stiffness between brain vasculature and parenchyma promotes metastatic infiltration through vessel co-option - Nature Cell Biology Uroz et al. report that the distinct mechanical properties of brain vasculature versus parenchyma drive cancer cell migration through a talin-dependent mechanism, enabling vessel co-option and metasta...

Hi #cancer, #ECMatrix, #biomaterials and #mechanobiology folks:
Below a Nat Cell Biol paper from the Chen and Weaver groups, of interest to many of us 🧪👇:

www.nature.com/articles/s41...

Intracellular cartilage oligomeric matrix protein augments breast cancer resistance to chemotherapy - Cell Death & Disease Cell Death & Disease - Intracellular cartilage oligomeric matrix protein augments breast cancer resistance to chemotherapy

Our newest publication examines whether an extracellular matrix protein has an intracellular function. Yes, it provides resistance to all known therapies for breast cancer.
www.nature.com/articles/s41...