Have you wondered what the wet lab success rates are for current AI-driven protein design models? Look no further!
In our new review, @kevinkaichuang.bsky.social
@avapamini.bsky.social, @sarahalamdari.bsky.social, and I report wet lab success rates for *over 200* different protein design tasks 🧬💻
the deadline is rapidly approaching:
🚨 Heads up, team mass spec: abstract deadline 30 April 📢
The next NVMS meeting (29 June, LUMC Leiden) is coming up fast! Don’t miss out and submit your abstract by 30 April: lnkd.in/ew2uBdpc
Showcase your work, connect with academia & industry, and compete for the poster prize.
Your NVMS board 🎉
1 month left!
www.brixenproteomics.org
I am so excited to share our new findings with you! We provide the structural evidence for a direct protein-to-DNA information pathway, showing how a bacterial enzyme 'reads' its own structure to 'write' DNA. www.science.org/doi/10.1126/...
Most biologics are glycosylated and some of them heavily. In this “fresh off the press" #glycotime preprint we look into how a filter that accounts for glycosylation explicitly in 3D can help reduce lab costs and increase the efficiency of de novo binder design pipelines. Short 🧵 ⬇️ 1/7
We have some fresh and cool #glycotime 🧪 on the impact of including glycosylation explicitly in de novo binder design. Filtering the results of a recent open competition for novel binders to the Nipah Virus Glycoptrotein (NiV-G) with ReGlyco improves the pipeline efficiency significantly ⬇️
Prokaryotes offer wonderful glycosylation diversity but are very hard to study. This software looks to be the tool to use to study them.
There's excellent attention to detail for the glycan aspect, which is often the underappreciated part of glycopeptides. I'm envious of the samples!
#glycotime
Exciting news from our lab 🎉
One of our talented postdocs, Dr. Robin Veenstra, has been awarded an NWO XS grant for the high-risk, high-reward project “Bridging the gap between virus and host.”
www.nwo.nl/nieuws/56-to...
Congrats Robin, and good luck with the project!
Opinie van @RenskeLeijten en mij in de Volkskrant (zonder betaalmuur nu) over de datakluis:
"Stilzwijgen over de datakluis is niets minder dan sabotage van de rechtsstaat"
www.volkskrant.nl/columns-opin...
Today we have @incarnatolab.bsky.social visiting for a seminar at the Bijvoet Center. Great talk!
Wat gebeurde er precies in Gorinchem? Hoe werden stemmen ‘geronseld’?
@tomkreling.bsky.social en ik zochten het uit.
www.nrc.nl/nieuws/2026/...
Dit is ongehoord en lijkt te duiden op een grote doofpot waar velen van afwisten. Als dit zelfs bij een parlementaire enquete achtergehouden wordt, is er probleem.
(1)
www.ad.nl/politiek/bel...
The small protein cryo-EM paper I helped start has been accepted in Nature Communications - what a relief. Thanks to @landerlab.bsky.social and @olibclarke.bsky.social for their constructive review. Congratulations to all co-authors, and wishing everyone good luck.
www.nature.com/articles/s41...
Today we celebrated, in the presence of the Dutch minister of Education, Culture and Science, Rianne Letschert, the NWO Roadmap grants, including the BioBeyond_NL and EMPower grants investing in infrastructures for biology beyond the genome and for electron microscopy in the Netherlands!
We have a 3-year post-doc position open. Apply now and join BioBeyond_NL to power up mass spec studies with new chemical biology tools!
www.uu.nl/en/organisat...
I would have never thought to study cetacean coronaviruses, but with @danielhurdiss.bsky.social @utrechtvirology.bsky.social being in the Faculty of Veterinary Medicine they keep turning up with all sorts of stuff from the farms and zoo's around here 😜
Out now at PLoS Pathogens @plos.org. Nice collaboration with @danielhurdiss.bsky.social @utrechtvirology.bsky.social. Some beautiful glycoproteomics work by @tshamorkina.bsky.social mapping N- and O-glycan shield of coronaviruses infecting whales and dolphins 🐋🐬🐳.
journals.plos.org/plospathogen...
We used our new ivRIC method to map host proteins inside HIV-1 particles, finding 100+ proteins that the virus hijacks to boost infection.
This project has a long history, spanning from pre-COVID to now! Driven by Manuel Garcia-Moreno and led by @alf-castello.bsky.social
tinyurl.com/54vb842w
The cartwheel was first visualized ~70 years ago in the symbiont Trichonympha in the wood termite gut. We’ve discovered the cartwheel’s secret: a unique zigzag stacking of SAS-6 tetramers that facilitates the iconic 9-fold symmetry of cilia.
#cellbiology #teamtomo #SAS6 #cartwheel
Decoding epitope immunodominance in HIV Env using cryoEM and machine learning pubmed.ncbi.nlm.nih.gov/41959402/ #cryoEM
Structure and assembly of Borna disease virus 1 nucleoprotein-RNA complexes pubmed.ncbi.nlm.nih.gov/41961918/ #cryoEM
For a plain-language overview of our work, see this lay summary courtesy of Kudos:
www.growkudos.com/publications...
Human monoclonal antibodies that target the SFTSV glycoprotein Gn head from four neutralizing epitope groups pubmed.ncbi.nlm.nih.gov/41955097/ #cryoEM
Wildlife trade drives animal-to-human pathogen transmission over 40 years
New in @science.org ‼️ In the most comprehensive study to date, we show that wildlife trade is driving animal-to-human zoonotic spillover at a planetary scale, with +1 spillover per host every 10 years. Live animal markets and illegal trade pose even greater risks. 🔓 www.science.org/doi/10.1126/...
Review on 20 years of Orbitrap MS!
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
From early days to today’s hybrid & Tribrid systems, it highlights how innovation, accessibility, and new applications shaped the field.
Orbitrap => true workhorse of modern MS 🔬
Cetacean coronavirus spikes highlight S glycoprotein structural plasticity pubmed.ncbi.nlm.nih.gov/41950284/ #cryoEM
Out now at PLoS Pathogens @plos.org. Nice collaboration with @danielhurdiss.bsky.social @utrechtvirology.bsky.social. Some beautiful glycoproteomics work by @tshamorkina.bsky.social mapping N- and O-glycan shield of coronaviruses infecting whales and dolphins 🐋🐬🐳.
journals.plos.org/plospathogen...
Our paper describing the #cryoEM structures of unusual spike proteins from marine mammal–infecting gammacoronaviruses is now published in PLOS Pathogens! 🐬
journals.plos.org/plospathogen...
