Accelerating Leigh syndrome drug discovery through deep learning screening in brain organoids - Nature Communications Leigh syndrome is a severe, currently untreatable mitochondrial neurological disorder. Menacho, Okawa et al. developed a deep-learning drug screening pipeline in brain organoids, identifying azole com...

Super excited to share our latest work! In collaboration with Antonio del Sol, we show that brain organoids coupled with deep learning screening allow uncovering new repurposable drugs for the incurable mitochondrial disease Leigh syndrome.
www.nature.com/articles/s41...

Drosophila models have been highly useful in dissecting the physiological roles of PINK1 and Parkin in #mitophagy

Led by 3 talented PhD students, we wrote a review summarising recent exciting discoveries and discussed these in context of current in vitro studies

portlandpress.com/biochemj/art...

Prof Giles Yeo - Gut Feeling: How new weight loss drugs work - 2025 British Science Festival YouTube video by The Genetics Society

If you’re looking for something to watch this weekend, here it is! @gilesyeo.bsky.social gives the @britsciassoc.bsky.social Biological Section presidential address.

Find out how new weight drugs work & spot @genotripe.bsky.social & @petergallivan.bsky.social cameos!
www.youtube.com/watch?v=NHDk...

Why choose JCS?
- FREE to publish (with OA options available)
- Fast-track option for papers with reports
- Submissions handled by Academic Editors
- Published by a not-for-profit publisher
- A tree planted for every peer-reviewed article🌳

Find out more at:
journals.biologists.com/jcs/pages/re...

🚨 Registration is open! 🚨
Join us for "Mitochondria Vol. 3: Mitochondrial Plasticity in Metabolism and Signalling", a free-of-charge international conference organized by the CRC 1218!

🗓 When: 05–07 October 2026
📍 Where: MTI, UzK Cologne, Germany

👉 Register now: mitochondria-volume3.uni-koeln.de

Had great fun engaging with the public to highlight the fun and importance of mitochondrial research #camfest

Find someone that loves you as much as @dgershlick.bsky.social loves RUSH!! Congrats!!

MitoTracker transfers from astrocytes to neurons independently of mitochondria The mitochondrial dye MitoTracker is commonly used to investigate intercellular mitochondrial transfer (IMT), particularly between astrocytes and neurons. Hole et al. compare MitoTracker with a geneti...

⚡️We are excited to share a new paper from the lab by @drkhole.bsky.social in @cp-cellrepmethods.bsky.social - suggesting MitoTracker dyes are not a reliable tool for detecting intercellular mitochondrial transfer❗️ www.cell.com/cell-reports...

Ooh great service to the community. Will def give it a try.

Rare Disease Day is TOMORROW!

This year, we're shining a light on mitochondrial disease — a rare genetic condition that affects the body’s ability to produce energy. Mitochondrial disease is just one of around 7,000 rare diseases recognised worldwide.

#RareDiseaseDay2026

Another recent paper in Fly on Drosophila in neuropathological research:
2/2 A new tool for accurately quantifying the extent of vacuolation in brain tissue in neurodegeneration models, from Kate Jordan, Flaviano Giorgini and colleagues
doi.org/10.1080/1933...

Three Group Leaders Professors Parkkinen, Magill and Houlden

Thrilled to announce three new UK DRI Group Leaders, joining the recently established Parkinson's Research Centre in partnership with @parkinsons.org.uk 🎉

👏 Prof Laura Parkkinen (Oxford)
👏 Prof Peter Magill (Oxford)
👏 Prof Henry Houlden (UCL)

Read more 👉 www.ukdri.ac.uk/news-and-eve...

Dear UK #Drosophila @FlyBase Cambridge is now able to accept PO orders for support. So please get in touch with
wiki.flybase.org/wiki/FlyBase:Contribute_...

Interesting initiative from Company of Biologists. Pay reviewers for a properly fast turnaround 👏

journals.biologists.com/bio/pages/fa...

Let’s see how it goes 👍

Scientists no Longer Find Twitter Professionally Useful, and have Switched to Bluesky Synopsis. Social media has become widely used by the scientific community for a variety of professional uses, including networking and public outreach. For

Bluesky is the new science Twitter, new study by @whysharksmatter.bsky.social and Julia Wester concludes!

"Results show that for every reported professional benefit that scientists once gained from Twitter, scientists can now gain that benefit more effectively on Bluesky than on Twitter."

Really happy to have joined the research committee and looking forward to helping @cureparkinsons.org.uk to improve the lives of people with Parkinson’s

I watched much of Ian Chapman's (Head of @ukri.org) appearance this morning at @ukparliament.parliament.uk Science, Innovation and Technology Committee..

A few points and new information that bioscientists may find interesting...

A 🧵

This is wonderful news and a reflection of the work of so many ppl to make the institute a fair and inclusive place to work, particularly Prof Hélène Plun-Favreau, Deputy Director for EDI, EDI project manager Dimitrios Zachos and Athena SWAN leads Prof Gabriele Lignani and Laura Allum.

Hey, it’s me! Very happy to chat about how to use flies to address biomedical questions.

Cute. Nice to know they have time for this while torching university based research.

@biochemsoc.bsky.social

Thanks, Cahir

Hey, science community (whoever is here). Can you please help me amplify this message? Postdoc position available in Düsseldorf!

@mrc-mbu.bsky.social

Drosophila models have been highly useful in dissecting the physiological roles of PINK1 and Parkin in #mitophagy

Led by 3 talented PhD students, we wrote a review summarising recent exciting discoveries and discussed these in context of current in vitro studies

portlandpress.com/biochemj/art...

LRRK2 integrates Rab and GABARAP interactions to sense and respond to distinct lysosomal stresses Increased activity of leucine-rich repeat kinase 2 (LRRK2) is an important risk factor for Parkinson’s disease. LRRK2 localizes to lysosomal membranes, and changes in lysosome physiology are emerging ...

New research led by Devin Clegg that defines how lysosome swelling and lysosome deacidification evoke distinct routes for LRRK2 activation: doi.org/10.1101/2025...

This is a great paper. Congrats to Derek and the whole team.

Looks like mitochondrial depolarisation is a bone fide PINK1-activating mechanism after all.

Next question: when does this occur at scale in neurobiology?

New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org.
rdcu.be/eKKz1 🇨🇦

Having fun enthusing young and old, expert and novice, about our mitochondria research at Cambridge’s Big Biology Day #PublicEngagement #Outreach @mrc-mbu.bsky.social

Amazing work @frisophagy.bsky.social and all the Chinnery lab team.