Crazy biochemistry is the norm for @schullerjm.bsky.social, but here I wanna say I have witnessed up close the amazing effort from @tomaspascoa.bsky.social and @tamb-o.bsky.social to chase the BCRII complex in situ 🤩

Big congrats to Lena Appel and @rnfr2d2.bsky.social for the cryoEM structure too 👏🏽

Across scales from cells🦠 to atoms⚛️ – We reveal how anaerobic #bacteria break down very stable aromatic compounds found e.g. in oil spills 🛢️ #Bioremediation #TeamTomo 🧪 🧶🧬 🔬

Awesome collab with Lena, Matthias, @schullerjm.bsky.social @rnfr2d2.bsky.social @tomaspascoa.bsky.social @tamb-o.bsky.social

Thanks for the fun collaboration into this fascinating “oil eating” biomachine. I learned a lot! 🧪 #TeamTomo

Amazing paper. A megadalton enzyme complex that:
- combines both electron bifurcation AND confurcation steps
- has a new type of iron-sulfur cluster
- a new kind of weird electron transfer path
- super charges electrons to reduce aromatic rings
- also powers respiration
😳

Yes that is nature's Lego in extreme. When you think you have seen it all... Go to anaerobes. ;)

How do “LEGO-like” electron-bifurcating modules combine to drive degradation in BTEX-contaminated ecosystems?

Check out our latest preprint, where we use cryo-EM and cryo-ET to reveal how the 1 MDa BCRII complex powers extremely endergonic aromatic ring reduction.
www.biorxiv.org/content/10.6...

Happy to present our latest story: the BCRII complex with the Boll and @cellarchlab.com . Months of processing by @rnfr2d2.bsky.social. Also @tomaspascoa.bsky.social and @tamb-o.bsky.social managed an in-situ tour de force. And Lena Appel did amazing biochemistry. This story has it all. Enjoy it.

1/ Excited to share our preprint! 🥳

Degradation of aromatic compounds, including BTEX pollutants, requires highly endergonic aromatic ring reduction. Using #cryoEM and in situ #cryoET, we show how BCRII couples electron bifurcation modules in one giant redox machine

www.biorxiv.org/content/10.6...

I will probably be hiring either a PhD or a Postdoc in the near future. If you are interested in deep biochemical history or molecular mechanisms of evolution please get in touch.

Congratulations 🎉 Anuj. This is well earned and I am a proud supervisor. There is much more coming. @rnfr2d2.bsky.social will present a paradigm shifting story this year at the GRC C1 and EBEC.

Carbonic anhydrase catalyses the interconversion of CO2 and HCO3- and helps increasing the net-CO2 concentration inside cells. Why? CO2-reducing enzymes like RuBisCO are notoriously slow and ineffective. However, import of HCO3- is typically coupled to ATP consumption...

Thrilled to be able to finally post my first adventure into secondary metabolism!:

Flavoaffinins, Elusive Cellulose-Binding Natural Products from an Anaerobic Bacterium

pubs.acs.org/doi/full/10....

Co-authors: Ruocheng Yu, f. undergrad Jessie Lee, @katherinem.bsky.social , and Emily Balskus!

Last Friday was the defense of my PhD thesis entitled "Structural basis of anaerobic enzymes mediated by noncanonical metalloclusters" after 4 yrs at the @synmikro.bsky.social 🎓🎓

Big thanks to my supervisor @schullerjm.bsky.social and the whole Schuller lab for their continuous and massive support!

The largest challenge of the day. Try to assemble 5 structural biology papers (each more than 100 pages incl. Supplements) in a single pdf with less than 15MB to upload as a document for a prize nomination for a student. Not sure compression algorithms are that good...

📢 Postdoc position: Cell Biology of Cyanobacteria

in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.

More information at shorturl.at/wNnDT (see Project 2)

🔗Apply at shorturl.at/VsEDl
📅Deadline: Nov 16, 2025

Please repost. #Postdoc

Congratulations Johannes. A milestone work! Thanks for including us in this exciting project. We are always happy to assist! What a beautiful structure and amazing evolutionary implications.

Really looking forward to it. It's a great opportunity to meet friends and make new ones. We are also excited to present our latest structural work on the methyl branch of methanogens. Unpublished and highly exciting!

Emergence of fractal geometries in the evolution of a metabolic enzyme - Nature Citrate synthase from the cyanobacterium Synechococcus elongatus is shown to self-assemble into Sierpiński triangles, a finding that opens up the possibility that other naturally occurring molecular-scale fractals exist.

www.nature.com/articles/s41...
By any chance??? It is a cyanobacteria right?

Origin of chaperone dependence and assembly complexity in Rubisco biogenesis Molecular chaperones assist with the folding and assembly of protein clients. Consequently, they are essential to diverse cellular functions. In most aerobic photosynthetic organisms such as B-cyanoba...

A new preprint from the lab. I won't do a tweetorial until this is peer reviewed, but I think it's a banger, led by
@JedNzy. It's about Rubisco and what chaperones are really for. He's on the market, get him while you can. www.biorxiv.org/content/10.1...

Oh wow, let's hope with our new discoveries we don't outdate it too fast ;)

Die aller♥️lichsten Glückwünsche🍾🥂auch von uns an Jan Schuller, Wissenschaftler👨🏼‍🔬bei LOEWE-Tree-M & zuvor bereits beim ehem. LOEWE-Zentrum SYNMIKRO, zu seinem #Explorationsstipendium der Boehringer Ingelheim Stiftung!
@synmikro.bsky.social @loewe-tree-m.bsky.social.

Structures of dynamic interactors at native proteasomes by PhIX-MS and cryoelectron microscopy Proteasome function depends on a network of transient interactions that remain structurally and functionally unresolved. We developed PhIX-MS (Photo-induced In situ Crosslinking-Mass Spectrometry), a ...

‼️ Exciting new preprint from a close collaboration with Kylie Walters' group. Our study maps the binding sites of key regulators of the proteasome in situ.
www.biorxiv.org/content/10.1...

What an amazing portrait for such an great violinist and scientist. Very well done. And very nice ending 😁 with the final in the music 🎶

He wants to reveal the secret behind the body's battery YouTube video by Wallenbergstiftelserna

Thank you Knut and Alice Wallenberg Foundation for producing this wonderful video on our research, and for the generous long-term support on our work. youtu.be/A12FvTn812Q

#PhDposition #OrganicChemistry #ChemBio - deadline 03.08 - please RT ❤️ Application online stellenangebote.uni-marburg.de/jobposting/d...

Non-antibiotics disrupt colonization resistance against enteropathogens Nature - Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of...

Finally online!
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG

we were already happy that these fascinating microbes were called 𝗶𝗻𝘁𝗿𝗮𝘁𝗲𝗿𝗿𝗲𝘀𝘁𝗿𝗶𝗮𝗹𝗲𝘀, but 𝗮𝗲𝗼𝗻𝗼𝗽𝗵𝗶𝗹𝗲𝘀 sounds definitively more, well... scientific (😎)
#MicroSky

This method is an absolute game changer 🔥 when applied to bioenergetic problems. You should have a read. Wait for it 😶‍🌫️ great things are coming!!!

Amazing paper, the best of two worlds- combination of high resolution cryoEM and small proteins - posttranslational Regulation of the core bioenergetic machinery of methanogenesis by a small protein! Well done Tristan and Eva!!👍🥂🥂 @schullerjm.bsky and @Schmitz-Streit lab - possible through @dfg.de

This work is a cornerstone in a long-term effort of the lab to understand the pumps of life. I call it a "Tripple in Bioenergetics" now.