Altered neutrophil signalling linked to impaired chemotaxis and increased ROS and NET production in older people with frailty In this study we have combined RNAseq with functional experiments to describe the phenotype of neutrophils from people with frailty. We found that frailty

Proud to share the 2nd PhD paper from @gnna.bsky.social

We performed RNAseq & assays (ROS,NETs, chemotaxis, killing) to describe inflammatory #neutrophils in people with #frailty

academic.oup.com/cei/article/...

FEBS Press Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y...

New paper from @gnna.bsky.social investigating altered neutrophil metabolism in healthy ageing & frailty. We found signatures of neutrophil activation, lipid metabolism & oxidative stress. #immunosky
@vivensa.bsky.social @livuni-ilcams.bsky.social

febs.onlinelibrary.wiley.com/doi/10.1111/...

Frontiers | Neutrophils and aortic medial amyloid: mutually beneficial or a dangerous combination? IntroductionAmyloid deposition and inflammation are associated with many human diseases, with inflammatory cells found co-localised with amyloid in a range o...

New paper from PhD student Sarah Shirley & @jmadine.bsky.social on the role of neutrophils in aortic amyloid disease

www.frontiersin.org/journals/imm...

Multiomics analysis of neutrophils in SLE: insights from adult and paediatric disease In this study we have taken a multiomics approach to study metabolism (NMR Metabolomics) and gene expression (RNA sequencing) in blood neutrophils from adu

Delighted that the 2nd paper from Dr Grace Filbertine is now online, we performed multiomics analysis of #neutrophils from adult and pediatric #SLE patients - similarities & differences reported @livuni-ilcams.bsky.social

academic.oup.com/cei/article/...

Congratulations to Dr Genna Abdullah @gnna.bsky.social who successfully defended her PhD thesis today. Thanks to examiners Dr Amy Chadwick & Dr Sonja Vermeren. Supervised by Dr Marie Phelan, Dr Asan Akpan & me. @livuni-ilcams.bsky.social

Altered neutrophil G-protein receptor signalling linked to impaired chemotaxis and increased ROS and NET production in older people with frailty Background: Immune function alters with age, and is often accompanied by chronic, low-grade inflammation (inflammageing). In individuals with frailty, inflammageing is increased, reducing immune funct...

Thrilled to share this pre-print from @gnna.bsky.social PhD. We combine RNAseq with functional experiments to describe #neutrophil phenotype in older people with #frailty
@vivensa.bsky.social @livuni-ilcams.bsky.social

www.medrxiv.org/content/10.6...

2025 Early Career Researcher Event - Vivensa Foundation All the highlights from our Early Career Researcher event in central London on 19 November 2025, including the speakers and panel.

Yesterday (19 November) we hosted our Early Career Researcher event at the Building Centre, London. Posters, peer networking, research showcases and a lively panel discussion made for an inspiring day. Read more here: vivensafoundation.org.uk/news/2025-ea...
#FundingForAgeingWell #ECREvent2025

Congratulations to @gnna.bsky.social who has been named Vivensa Foundation academy member of the month for her fantastic patient involvement activities during her research project in frailty & ageing of the immune system. Read more about her #PPI work here vivensafoundation.org.uk/award-holder...

Fab new pre-print from @gnna.bsky.social which identified biomarkers of oxidative stress & ageing in #neutrophils #frailty ⬇️

Shaping science together: Patient, carer and public involvement and engagement in ageing research - Vivensa Foundation We spoke to three Vivensa-funded researchers about the power of patient, carer and public involvement and engagement (PPIE).

Find out how @gnna.bsky.social @drhelenwright.bsky.social and Professor Chrissy Hammond are using PPIE. They share practical tips for tailoring PPIE activities to older participants and funding models that help PPIE to flourish: vivensafoundation.org.uk/award-holder...
#PPIE #FundingForAgeingWell

Delighted to share our latest review article written by @gnna.bsky.social on #neutrophil #ageing #inflammageing #frailty
#immunosky
🧪

@livuni-ilcams.bsky.social @vivensa.bsky.social

academic.oup.com/jleukbio/adv...

Four images showing the making of elderberry syrup.

Tried my hand at foraging today. Lovely ripe elderberries from the local park. Added fresh ginger, cinnamon and honey. Made just under 500ml. Yummy. 🌱

Autophagy inhibitors block pathogenic NET release in immune-mediated inflammatory disease without impairing host defence AbstractObjectives. Activation of neutrophils and release of neutrophil extracellular traps (NETs), proteases and reactive oxygen species (ROS) is pathogen

New paper identifying the role of autophagy in the production of #neutrophil #NETs A potential novel therapeutic target in #SLE #rheumatoidarthritis ? Congratulations to Dr Andy Nolan & colleagues in
@pseudoenzyme.bsky.social lab

@livuni-ilcams.bsky.social

academic.oup.com/rheumatology...

Serum metabolomics identifies unique inflammatory signatures to distinguish rheumatoid arthritis responders and non-responders to TNF inhibitor therapy - Metabolomics Introduction Rheumatoid arthritis (RA) is an auto-immune disease which causes irreversible damage to tissue and cartilage within synovial joints. Rapid diagnosis and treatment with disease-modifying t...

New paper on the application of NMR and IR metabolomics to identify responders to TNF inhibitors #rheumatoidarthritis #livuni @micfresneda.bsky.social @roygoodacre.bsky.social @versusarthritis.bsky.social @liverpooluni.bsky.social

link.springer.com/article/10.1...

Thanks, I did mention it to the fair Caroline a few weeks ago so assumed she’d tell you!

The Lizzano cherry toms are the earliest cropping and the tastiest tomatoes we’ve ever grown, super sweet 🍅 🌱

Super excited for the tomato harvest that’s just starting. We’ve got Lizzano cherry toms in hanging baskets and gardeners delight, crimson crush and marmande in the polytunnel 🍅 🌱

At the moment I’m having a break and spending more time looking after my allotment and myself 🧡

First cabbage of 2025! 🌱

Yesterday was my last day at the University of Liverpool after 20 incredible years. We’ve still got some papers to finish so watch this space for updates. Now, to the allotment!

From the allotment - potatoes, blackberries, lettuce, runner beans, courgettes, cucumber, tomatoes, sweet peas

Nice haul for a Friday at the allotment - new potatoes, blackberries, lettuce, runner beans, tomatoes, courgettes, cucumber, sweet peas 🌱

Thrilled to receive the ‘Mentor’ award at @livuni-ilcams.bsky.social away day. Supporting the next generation of scientists has always been incredibly important to me, and it’s lovely to be nominated so THANK YOU if you were one of the people who put me forward for this award.

The kale was passed to us by an allotment holder and I though the same, but it’s actually delicious

Rather you than me 😂 (and I do love Stilton)

My husband made it. It was white onion, 2 cloves garlic, 3 fairly large courgettes, stock, Philadelphia cheese (about a third of a tub), salt & pepper. I whizzed it up and took all the credit 😂 The kale was just chopped and steamed.

My husband made it. It was white onion, 2 cloves garlic, 3 fairly large courgettes, stock, Philadelphia cheese (about a third of a tub), salt & pepper. I whizzed it up and took all the credit 😂 The kale was just chopped and steamed.

The allotment is bountiful this year. Lunch today was courgette and kale soup. Absolutely delicious. 🌱

Was called a “c*nt in a mask” this morning at my local Sainsbury’s 😷 Have a lovely day mate and good luck with your “summer flu” (BTW it’s not flu) 🦠

First courgette of the year, so had to make this absolute banger of a salad - courgette, rocket, feta, pine nuts, garlic and lemon juice 😘 👌🏼

Complexity of the neutrophil transcriptome in early and severe rheumatoid arthritis: a role for microRNAs? Rheumatoid arthritis neutrophils have heterogeneous gene expression profiles associated with neutrophil polarization and activation states, which we propos

New paper on #neutrophil #transcriptomics in #rheumatoidarthritis now online, congrats @micfresneda.bsky.social @gnna.bsky.social #immunosky

academic.oup.com/jleukbio/adv...