New paper alert: Our latest shows how maternal diet impacts ribosome levels and early growth intergenerationally in #Celegans

Led by Sigma Pradhan and in collab with @nstroustrup.bsky.social

journals.plos.org/plosbiology/...

@plosbiology.org @izb-unibern.bsky.social @unibe.ch

Check out our work on maternal effects of diet on progeny growth and ribosomes! Thanks also to Elif Cenik for insightful Primer discussing our paper. dx.plos.org/10.1371/jour...

A new study by #unibern shows: The nutritional conditions of a #nematode mother influence the growth of her #offspring. If she receives less food, she equips her offspring with fewer #ribosomes, causing them to grow more slowly at first. mediarelations.unibe.ch/media_release…

Eine neue Studie der #unibern zeigt: Die Ernährungsbedingungen einer #Fadenwurm-Mutter beeinflussen das Wachstum ihrer #Nachkommen. Bekommt sie weniger Nahrung, stattet sie ihre Nachkommen mit weniger #Ribosomen aus, wodurch diese anfangs langsamer wachsen. mediarelations.unibe.ch/medienmitteil…

How do wealthy parents help their offspring? By giving them ribosomes!

Optimal ribosome provisioning is key to fast development in unpredictable environments. The fastest path to ribosomal wealth in nematodes is a maternal inheritance.

Happy we could play a small part in this fascinating work.

Link to thread from preprint below. But check the paper for more on tissue-specificity and functional impact.

bsky.app/profile/beto...

New paper alert: Our latest shows how maternal diet impacts ribosome levels and early growth intergenerationally in #Celegans

Led by Sigma Pradhan and in collab with @nstroustrup.bsky.social

journals.plos.org/plosbiology/...

@plosbiology.org @izb-unibern.bsky.social @unibe.ch

with fantastic
Hanna Kokko - @kokkonut.bsky.social
Francis Corson
Oliver Meacock - @olimeacock.bsky.social
Gasper Tkacik
Mor Nitzan - @mornitzan.bsky.social

Free registration for LS2 members, symbolic fee for others.
Abstract deadline for selected talks: 10 May.

Join us at the LS2 #Theory #across #Biology chalk talk symposium! 12 June 2026 in Bern, CH. @lifesciswitzerland.bsky.social

No movies that fail, no Mac to PC issues. Only the best ideas and exchange across biology from evolution and ecology to physics of life.

meetings.ls2.ch/theory-acros...

Tenure-track Assistant Professorship in #Quantitative #Cell #Biology at the ICB @unibern. Apply until 17 October. Combination of theory/computation and experiments particularly encouraged. Please repost!

www.nature.com/naturecareer...

Assistant Professor with tenure-track for Quantitative Cell Biology (80-100%) - Bern, Switzerland job with University of Bern, Institute of Cell Biology | 12840798 Assistant Professor with tenure-track for Quantitative Cell Biology (80-100%) at the University of Bern, Switzerland.

Exciting opportunity for TT-Ass #Professorship in Quantitative Cell Biology
@unibe.ch @izb-unibern.bsky.social! Applicants combining experimental and computational approaches/theory are particularly encouraged. Great colleagues, environment, infrastructure. What's not to like?
tinyurl.com/42f3p863

What is this?

Last chance to submit an abstract for the LS2 Systems Biology Symposium! Extended deadline: Sunday, 27.4.

✅Present your work in interactive talk sessions!
✅Get feedback from your peers!
✅Find the collaborator that solves all your problems!

Submit now & rest on the weekend!

Warm memories of a defining time...
So sad to have missed this.

אין כמו אורי!

Last chance to submit an abstract for the LS2 Systems Biology Symposium! Extended deadline: Sunday, 27.4.

✅Present your work in interactive talk sessions!
✅Get feedback from your peers!
✅Find the collaborator that solves all your problems!

Submit now & rest on the weekend!

Compression of morbidity by interventions that steepen the survival curve - Nature Communications Longevity research aims to extend lifespan and reduce sickspan in aging. Here, the authors show that only interventions that steepen survival curves can compress the sickspan relative to lifespan.

Our latest on aging, where we reveal an unexpected link between healthspan and equality of lifespans.
By @y1fanyang.bsky.social , out now @naturecomms.bsky.social
www.nature.com/articles/s41...

Every Progress Report

📢Join us tomorrow, Friday, March 28th at 10:00, for an exciting talk by @olmedo-lab.bsky.social at the ICB!

She’ll be presenting:
"Maintenance of cell quiescence during starvation in C. elegans"

Don’t miss this opportunity to dive into fascinating research! More info on our website: izb.unibe.ch

Congratulations to Jana Brunner on successfully defending her PhD this week! 🎉 Jana investigated the molecular mechanisms of developmental timing in the worm C. elegans 🪱

early career researchers: Do not miss this oportunity to present and discuss your work with an expert audience!

🚨 Join us for the LS2 Swiss #Systems #Biology Symposium in Bern!

❌ to talk marathons
✔️ to new connections and interactions

➡️Mini parallel sessions with Q&A during the talks.

Keynotes by @ehannezo.bsky.social @leeat-keren.bsky.social

tinyurl.com/5hf485ee

@lifesciswitzerland.bsky.social

Eukaryotic Elongation Factor 2 Kinase EFK-1/eEF2K promotes starvation resistance by preventing oxidative damage in C. elegans | Nature Communications Cells and organisms frequently experience starvation. To survive, they mount an evolutionarily conserved stress response. A vital component in the mammalian starvation response is eukaryotic elongation factor 2 (eEF2) kinase (eEF2K), which suppresses translation in starvation by phosphorylating and inactivating the translation elongation driver eEF2. C. elegans EFK-1/eEF2K phosphorylates EEF-2/eEF2 on a conserved residue and is required for starvation survival, but how it promotes survival remains unclear. Surprisingly, we found that eEF2 phosphorylation is unchanged in starved C. elegans and EFK-1’s kinase activity is dispensable for starvation survival, suggesting that efk-1 promotes survival via a noncanonical pathway. We show that efk-1 upregulates transcription of DNA repair pathways, nucleotide excision repair (NER) and base excision repair (BER), to promote starvation survival. Furthermore, efk-1 suppresses oxygen consumption and ROS production in starvation to prevent oxidative

EFK-1/eEF2K in C. elegans enhances starvation resistance by preventing oxidative damage. Crucial for survival & linked to eEF2 phosphorylation. #BioResearch PMID:39966347, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56766-1 #Medsky #Pharmsky #RNA 🧪

Are you thinking about yourself or the students? 😀. After 2hrs of teaching, i feel typically like i ran a cognitive marathon...

Job opening in my research group!! Please share.

I'm looking for a lab technician to join my small team investigating how chromatin structure regulates gene expression in C. elegans.

www.fmi.ch/education-ca...

Amazing stuff!

Thanks!

Thanks!

Thanks!

Thanks. Still thinking about an appropriate walk up song for this 🙃.

Thanks! We do not exclude an additional role for modifications/heterogeneity. But our data suggests that levels are at least sufficient for the effects observed: direct (and presumably modification unspecific) depletion of R-proteins to a similar degree had the same effect on growth as maternal DR.