TCF1 is a master regulator of T cell stemness – but can it make exhausted cells go backwards?

We setup a CRISPR KI system to ask this question, and the answer was unexpected.

www.nature.com/articles/s41...

γδ T cell-derived IL-4 initiates CD8+ T cell immunity - Nature Immunology The authors show how Vγ1+ γδ T cells produce IL-4 to drive early CD8+ T cell and dendritic cell responses to malaria infection in mice.

Ever wondered why gamma delta T cells are required for immunity to liver-stage malaria?

www.nature.com/articles/s41...

Medical Research Matters

Right now, the Government is starving medical research of full funding, even as it claims that science and research are national priorities. If our leaders truly value science as much as they say, then they must back their words with action—and fund it properly.

Join the campaign!

Thanks to funding through the NHMRC's 2025 Synergy and Ideas grants, 27 UniMelb projects have secured $52 million to help turn bold ideas into meaningful impact.

Congratulations to everyone involved 👏

Tap through to read more → unimelb.me/4b6xNms

Looking forward to @categraca.bsky.social presenting our recent work. Tune in!

Online now: Microbiota-derived butyrate promotes a FOXO1-induced stemness program and preserves CD8+ T cell immunity against melanoma

‼️Deadline approaching - Don't miss your chance to submit an oral abstract for 16th Annual Lorne Infection & Immunity Conference
📍Held 18-20 of February 2026 at the Mantra Lorne

📝 Career Development Awards also available

Apply at www.lorneinfectionimmunity.org

Deadline: Friday, 10th of October

Billions going unspent from Australia’s $24b medical research fund Costings commissioned by independent MP Monique Ryan reveal the government could double how much funding it gives to innovative health research each year.

www.theage.com.au/politics/fed...

CSH Asia meeting on Immune Tolerance #CSHA

TGFβ-driven, HOBIT-dependent tissue-residency programs promote tumor-infiltration of CD8 T cells, but disruption of TGFβ in these tumor-infiltrating cells enhances tumor control @natimmunol.nature.com www.nature.com/articles/s41...
www.nature.com/articles/s41...

Congrats @yannick-alexandre.bsky.social and team. Great study

We're looking for an experienced lab manager to join our wonderful team investigating fundamental T cell biology 🤓
careers.pageuppeople.com/513/cw/en/jo...

Congrats Jan!

Great meeting to (be) lock(ed) in!

We are recruiting a group leader in laboratory research at Peter Mac Cancer Centre in
Melbourne, Australia 🔬🦘💥

Work in a cutting edge research environment in a vibrant world city!

We value research excellence, creativity and diversity.

Join us!

careers.petermac.org/job/MELBOURN...

Trump 2.0: an assault on science anywhere is an assault on science everywhere US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.

Inexplicably, US administration has launched an unprecedented assault on science, on research institutions & on vital international organizations & initiatives.

An assault on science anywhere is an assault on science everywhere; the global community must unite
🧪
www.nature.com/articles/d41...

Check out our new paper!

Congrats @niclag.bsky.social @pzareie.bsky.social and team! 🎉

In the media over the weekend, groundbreaking research from Peter Mac & The Doherty has uncovered a new way to enhance the immune system’s ability to fight cancer.

Work at Peter Mac led by @JohnstoneRicky and Dane Newman. More via @australian or here: www.petermac.org/about-us/new...

Thanks Steve!

Very excited about this collaborative study between @petermaccc.bsky.social @danielutzschneider.bsky.social and Kallies lab

ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer
www.science.org/doi/10.1126/...
@sciimmunology.bsky.social

Very happy to share our new work!

Not sure I would be able to focus on the pub😂

Thank you to all the collaborators, including @rauschlisa.bsky.social, @ajithvasanthan.bsky.social, @bendinglab.bsky.social and everyone @thedohertyinst.bsky.social & @petermaccc.bsky.social

How could this work?

IL-1 cytokines expand ID3+ stem-like T cells in vitro, boosting their ability to sustain T cell responses in chronic infections & cancer.

This could pave the way for next-gen T cell therapies with enhanced longevity & efficacy. Exciting possibilities ahead!

ID3+ T cells in acute settings show unique stem-like features, including the ability to sustain long-term immunity and exclusively form #Tpex cells in chronic infection & cancer.

Could this improve durability in T cell therapies? We think so! 🧬

#Tpex cells are key to sustaining T cell responses to chronic infection & cancer. Can we learn from #Tpex cells, and harness stem-like T cells in acute infection to improve chronic immune responses?

Yes! T cells identified in acute LCMV expressing ID3 and LY108 shape durable therapies

Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer.

Excited for our lab's FIRST paper #ScienceImmunology! 🎉

Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social

Huge thanks to reviewers & @claireolingy.bsky.social 🙌

#Tpex #onthescoreboard

www.science.org/doi/full/10....