Have a look at this PhD program in Vienna- most interesting science and the best training program:

International Genome Dynamics course in Institut Curie-Paris (April 8-15), experimental and computational methods in multiomics,with a #TE centered session.
Free registration, until Jan 15th
Don’t miss it!
👉training.institut-curie.org/courses/Genome-Dynamics-...
@institutcurie.bsky.social

H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations Nitsch et al. show that short-chain acylations of histone H4K16, acetylation (C2), propionylation (C3), and butyrylation (C4) modulate chromatin structure in vitro. These effects can translate in vivo...

Now final version out: Our manuscript connecting histone modifications with metabolism: How H4K16 acylations regulate inter +intranucleosomal interactions and confer resilience to metabolic challenges in vivo. Thanks to the team+ @sandrani.bsky.social

Enjoy 👇👇 www.cell.com/molecular-ce...

Happy birthday to Xenbase! Our research would have not been possible without you and your fantastic community support 🤩

thank you! I am definitely curious to see if this represents a true epigenetic mechanisms. The future will (hopefully) tell!

Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo Enhancers control tissue-specific gene expression across metazoans. Although deep learning has enabled enhancer prediction and design in mammalian cell lines and invertebrate systems, it remains uncle...

Our preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)

Hidden sampling biases inflate performance in gene regulatory network inference Accurate reconstruction of gene regulatory networks (GRNs) from single-cell transcriptomic data remains a major methodological challenge. Recent machine learning approaches, particularly graph neural ...

Our new preprint is out: www.biorxiv.org/content/10.6...
We show that GRN benchmarks commonly used can overestimate performance due to negative-sampling choices, sometimes allowing simple degree-based baselines to rival more complex GNNs.
A reminder of why bias-aware evaluation matters!

After a long journey, I'm happy to share that my PhD work is finally published in Nature Communications. Grateful to all my co-authors!

one should stop when it is at its nicest :) and I am looking forward to seeing where these findings on epigenetic memory take the field next!

It was also a real pleasure to work with the @crc1064.bsky.social community and our brilliant collaborators @antonio-scialdone.bsky.social, Stephan Hamperl, and @jellevda.bsky.social. Their expertise was vital.

The credit goes to my colleagues @meghana-oak.bsky.social and @marcostock.bsky.social, who drove this project and continued these demanding experiments with incredible persistence

It’s a story of marks written early, carried through a long silence, and then suddenly speaking again. A bit like memory itself.

In Xenopus laevis, we found that H3K4 methylation is already laid down at specific loci in gametes and silent early embryos. This pre-marking is essential for accurate zygotic genome activation and proper development.

We probably shouldn’t have favourites amongst projects in the lab, but this one was mine. I’m so pleased we can finally share it:

Our work is now out in Nature Communications:
🔗 nature.com/articles/s41467-025-67692-7

Academic employee for Research Group, Dept. of Biomedical Sciences, reNEW

Do you want to play a key role in running a cutting-edge stem cell and embryology lab at reNEW @ucph.bsky.social ? We’re hiring a Lab Manager to support our team and help with stem cell and animal work. Apply before Feb. 1st : rb.gy/d5uf17

I’m thrilled to share that our project, FATERNA, has been awarded an ERC Consolidator Grant! We’ll explore the mechanisms of pre-mRNA fate control. Huge thanks go to our awesome research team, colleagues, and the fantastic support from @impvienna.bsky.social & @viennabiocenter.bsky.social CP.

Feed-forward loops by NR5A2 ensure robust gene activation during pre-implantation development Pioneer transcription factors are crucial for regulating zygotic genome activation and cell differentiation during mouse pre-implantation development. However, how pioneer factors function collectivel...

Excited to announce that our peer-reviewed manuscript is online in the Development journal @dev-journal.bsky.social. The manuscript was much improved through the peer-review process, and I am grateful to the reviewers for their valuable feedback.

journals.biologists.com/dev/article/...

Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon - Nature Communications Nature Communications - Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon

A close-up piece on the legacy of Sir John Gurdon - so happy to see this out at @natcomms.nature.com. Excellent editorial and community work by @ebardot.bsky.social & thank you, @evahoermanseder.bsky.social et al.!

www.nature.com/articles/s41...

Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon - Nature Communications Nature Communications - Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon

We have just published a tribute to John Gurdon, reflecting on his scientific legacy and the profound influence he had on generations of developmental biologists.

The piece is available open access in Nature Communications:
www.nature.com/articles/s41...

Thank you Evan!

Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon Nature Communications - Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon

We are honored to share our Perspective in Nature Communications, reflecting on the legacy of John B. Gurdon.
Beyond his discoveries, his generosity and curiosity inspired a community of scientists-we remember and celebrate his lasting impact. #JohnGurdon #Xenopus #NatureCommunications

Yearly Lab Luncheon at John’s place. 2017

She Worked in a Harvard Lab to Reverse Aging, Until ICE Jailed Her (Gift Article) President Trump’s immigration crackdown ensnared Kseniia Petrova, a scientist who fled Russia after protesting its invasion of Ukraine. She fears arrest if she is deported there.

The Americans are doing to Kseniia what the Russians did to Brittney Griner for having 0.7 grams of cannabis oil. Except no one is coming to negotiate her freedom and Harvard is sitting on their hands. I am so ashamed. Please share this story.
www.nytimes.com/2025/04/11/s...

#EpigeneticsPodcast with #HelmholtzMunich expert Dr. Eva Hörmanseder, @epihmgu.bsky.social!

🎧 Listen and learn about epigenetic memories & more:
👉 t1p.de/30q54

👉Check out her latest findings on this topic:
t1p.de/43yrw

@epigeneticspod.bsky.social
#Epigenetics #Podcast #Reprogramming #CellFate

In the most recent episode we talked with @evahoermanseder.bsky.social from @www.helmholtz-munich.de‬ about her work on epigenetic mechanisms in cellular memory and gene regulation. #podcast #epigenetics

Listen here: activemotif.com/podcasts-eva...

Russian scientist working at Harvard detained by Ice at Boston airport Kseniia Petrova was returning to the US from a trip to France when officials revoked her visa and detained her

This is very disturbing.
Harvard PhD student Kseniia Petrova (Russian citizen) was arrested by ICE for transporting xenopus embryos into Boston from Paris. She has been detained in Louisiana since Feb. 16.

www.theguardian.com/us-news/2025...

If I could do it all over again, I’d apply here for my postdoc- look at these fantastic opportunities! ⬇️

Reprogramming efficiency varies across cell types in vivo and is modulated by somatic cell identity memory. Eliminating somatic cell transcriptional memory improves reprogramming success #nucleartransfer ow.ly/g1Au50VimTM

@www.helmholtz-munich.de @isscr.org

Fast & Fair peer review A new initiative offering high-quality peer review within 7 working days of submission Biology Open

We’d like to thank our Editors and peer reviewers who made the #fastandfairpeerreview trial possible. Would you like to join our reviewer pool? Visit bit.ly/41N31tO for more details.

Harvard scientist opposed to Ukraine war faces deportation back to Russia: Friends Kseniia Petrova has been in U.S. detention since mid-February after having her visa revoked, according to friends and independent Russian media

Harvard scientist opposed to Ukraine war faces deportation back to Russia: Friends. This sounds like Trump trying to please Putin rather than anything to do with US immigration.
www.independent.co.uk/news/world/a...