🚨 New paper alert 🧬
Our work from the @michellepeckham.bsky.social lab is now out in #ScienceAdvances.

We present the #cryoEM structure of shutdown human non-muscle myosin 2A, showing how ionic interactions stabilise auto-inhibition and how mutations disrupt this state.

👉 tinyurl.com/4de8teyh

Next month, Jarrett Johnson of @schrodingerinc.bsky.social will be giving an @sbgrid.bsky.social webinar on "Upcoming improvements to visualization and CryoEM support in PyMOL”.

For more info and to sign up, see here:
instruct-eric.org/events/sbgri...

Yesterday we had a fantastic guest in the Structural Biology course of the Master’s in Cellular and Molecular Biology @usaloficial.bsky.social

Thank you @xalbertdelacruz.bsky.social for your outstanding presentation on structural biology applied to plant biotechnology!

📢 External seminar at the IBFG!

🥼Talk by Dr. Fernando Moreno-Herrero - CNB-CSIC (Madrid, Spain)
🔬Topic: Single-molecule approaches to study protein machines involved in DNA metabolism

🗓️ April 17, 2026 – 12:00 PM
📍 IBFG Auditorium, Salamanca

Electron Crystallography workshop 2026 <p><strong>About</strong></p> <p>There is no science without communication. We invite you to attend a workshop on Electron Crystallography and present your research on <strong>all aspects of 3D ED /…

Electron Crystallography workshop 2026
📅 11 – 13 May 2026
📍 Warwick's Venice Campus, Italy
📝 Registration Open| Deadline: 17 April 2026
🔗

Integrin ß4 is a receptor for emerging fungal pathogens from the genera Lomentospora and Scedosporium Author summary Lomentospora prolificans is recognized as a priority fungal pathogen by the World Health Organization due to its rising clinical significance to cause life-threatening infections that a...

Integrin ß4 is a receptor for emerging fungal pathogens from the genera Lomentospora and Scedosporium
Kavaliauskas et al
PLoS Pathog
dx.plos.org/10.1371/jour...
"Integrin β4 serves as a receptor that promotes initial binding of L. prolificans to airway epithelial cells".

Conformational landscape of integrin α4β1 and its recognition of VCAM and conformation-stabilizing small molecules
www.researchsquare.com/article/rs-8...

8th Instruct | FRISBI | PSB Grenoble Cryo-EM Course on Sample Preparation <p><img src="https://instruct-eric.org/upload/nOyS9ZN04jpBMHRN82vhcPbOmNcSlgQa.png" /></p> <p>We are pleased to announce the eighth hands-on practical course on sample preparation for single-particle…

Deadline closing this Sunday!
Instruct | FRISBI | @psb-grenoble.bsky.social Cryo-EM Course on Sample Preparation
📅 19 – 22 May 2026
📍 European Photon and Neutron Campus, Grenoble, France
🔗 instruct-eric.org/events/8th-i...

#CryoEM #Training

Microtubules in the axon are GDP bound but adopt a stable GTP-like expanded state Nature Structural & Molecular Biology, Published online: 08 April 2026; doi:10.1038/s41594-026-01787-7Zehr et al. revealed the 2.7-Å cryo-electron microscopy reconstruction of human microtubules in situ in the axon of induced pluripotent stem cell (iPS cell)-derived neurons. It shows an expanded microtubule lattice yet bound to GDP, in contrast to the compacted lattice observed at the iPS cell stage.

New online: Microtubules in the axon are GDP bound but adopt a stable GTP-like expanded state

8th Instruct | FRISBI | PSB Grenoble Cryo-EM Course on Sample Preparation <p><img src="https://instruct-eric.org/upload/nOyS9ZN04jpBMHRN82vhcPbOmNcSlgQa.png" /></p> <p>We are pleased to announce the eighth hands-on practical course on sample preparation for single-particle…

Instruct | FRISBI | @psb-grenoble.bsky.social Cryo-EM Course on Sample Preparation
📅 19 – 22 May 2026
📍 European Photon and Neutron Campus, Grenoble, France
📝 Registration Open| Deadline: 12 April 2026
🔗 instruct-eric.org/events/8th-i...

#CryoEM #Training

HPA-1a antibodies in FNAIT do not distinguish αvβ3 from αIIbβ3, and bind inactive integrins more strongly than active integrins Key PointsAnti–HPA-1a antibodies exclusively recognizing integrin αvβ3 were not detected in maternal sera from patients with FNAIT.Anti–HPA-1a antibodies b

HPA-1a antibodies in FNAIT do not distinguish αvβ3 from αIIbβ3, and bind inactive integrins more strongly than active integrins
ashpublications.org/blood/articl...

In pursuit of FNAIT biomarkers: αVβ3 specificity falls short In this issue of Blood, Oosterhoff et al1 revisit a widely cited hypothesis: that maternal alloantibodies directed preferentially against integrin αVβ3, ra

In pursuit of FNAIT biomarkers: αVβ3 specificity falls short
ashpublications.org/blood/articl...

SBGrid Software Webinar - Image processing made simple with scipionTomo <p>SBGrid is happy to present a software webinar. This session will be delivered by Jose Luis Vilas, Ph.D., who is an Investigator at the National Biotechnology Center, CSIC in Spain. This session…

On 14 April 2026, Jose Luis Vilas, Investigator at @cnb-csic.bsky.social will be delivering a @sbgrid.bsky.social webinar on image processing using the Scipion software package!

For more info and to sign up, please see our website:

First deposition of a structure determined at XAIRA XAIRA beamline reached another milestone, with the first deposition of a new macromolecular structure in the Protein Data Bank determined from diffraction data obtained at XAIRA. The deposition of the atomic structure of this protein complex represents an early result of the beamline’s recently launched user program, with many more structures expected to follow.

This finding establishes EPCR as a genuine receptor for FVIIa, overturns the view that EPCR is restricted to protein C/APC binding, and provides a structural explanation for how rFVIIa may influence protein C activation during haemophilia therapy.

Structural basis of human γTuRC closure during CM1-activated microtubule nucleation pubmed.ncbi.nlm.nih.gov/41888131/ #cryoEM

cryoEM maps of the different assemblies

New preprint

www.biorxiv.org/content/10.6...

A stepwise mechanism for RAF1 activation involving novel assemblies exclusive of HSP90 RAF clients influencing MAPK signaling. Great collaboration between our group and the groups of @jespervolsen.bsky.social and M. Barbacid @cniostopcancer.bsky.social

EMBO Practical Course: Advances in cryo-electron microscopy and 3D image processing <p>We are delighted to announce the 2026 EMBO Practice Course on “<a href="https://www.embl.org/about/info/course-and-conference-office/events/cry26-01/#vf-tabs__section-dtc24-01" target="_blank"…

@embo.org Practical Course: Advances in cryo-electron microscopy and 3D image processing
📅 17-25 August 2026
📍 @embl.org Hamburg
📝 Registration Open| Deadline: 11 May 2026
🔗 instruct-eric.org/events/embo-...

#cryoEM #Training

SBBC contributes to the MSc in Cellular & Molecular Biology @usaloficial.bsky.social via the Structural Biology in Biotech & Biomedicine course. We enjoyed a virtual visit to #XALOCbeamline #ALBAsynchrotron with #FernandoGil. Huge thanks for the great explanation!

Biophysics Week | The Biophysical Society About Join RenewDonateAdvertiseNews

Happy #BiophysicsWeek! This week is full of free events sponsored by BPS, Subgroups, and Affiliate Event organizers. And don't miss the many biophysics resources created by BPS committees!

Demà tenim la #Biophyzza2025 a València, part d la #TheBiophyzzaConnection organitzada per #SocBiofísicaEsp celebrant la #BiophysicsWeek d la @biophysicalsoc.bsky.social
Amb 🍕 i 🍺

📍 Sala Darwin, Campus Burjassot @uv.es
🕓 16:30h
Vos esperem‼️

Added custom menus, including one to quickly add common monomers (detergents, buffers etc):

A postdoctoral position is available at ALBA Synchrotron, part of the expanded Instruct Centre Spain!

The position involves driving the beamline capabilities and fostering existing and potential user communities in structural biology!

Find out more here - instruct-eric.org/jobs/postdoc...

Our first #BiophysicsWeek! 🧑‍🔬+🍕=👇

Studying molecular affinity feels a lot like first dates: it's all about compatibility, attractive forces, and whether the interaction is strong enough to last. #BiophysicsWeek @sbesp.bsky.social

Many thanks to @ibfg.bsky.social for hosting us, SBBC members for the excellent organization, and to @sbesp.bsky.social for the initiative that made this event possible. Great science, even better collaboration—and thanks to @dominos-pizza.bsky.social for the delicious pizzas

Family photo from the first #BiophysicsWeek @monicabalsera.bsky.social @olgacalvog.bsky.social @peredalab.bsky.social #RubenMBuey #CarlosRodríguez

The Biophyzza Connection 2026 | Spanish Biophysical Society LA “BIOPHYSICS WEEK” Y LA “BIOPHYZZA CONNECTION” 2026

Lots of #BiophysicsWeek activities are taking place this week across Spain, including "Biophysics in Salamanca: Can Biophysics Explain Life?" and "Biophyzza 2026: May the (membrane) Force be with you" today! sbe.es/the-biophyzz...

Let's get started! #BiophysicsWeek @sbesp.bsky.social

Mitochondria or pepperoni?? 🍕

One gives you energy, the other IS the energy...#BiophysicalWeek @sbesp.bsky.social @dominos-pizza.bsky.social

Miguel Vicente‑Manzanares, del @ciccancer.bsky.social (@csic.es ‑ @usaloficial.bsky.social ‑FICUS), firma una revisión en Biophysical Reviews en la que resume cómo la miosina II organiza la fuerza mecánica en el interior de las células y cómo su mal funcionamiento contribuye a varias enfermedades