Uridine Uridine is a pyrimidine nucleoside composed of an uracil base and a ribose sugar. In cells, uridine is predominantly present in RNA (as uridine monophosphate, UMP). Uridine can be produced through de novo UMP synthesis or salvaged from the blood or intracellular sources like RNA. Under energy stress, uridine is catabolized by uridine phosphorylase (UPP1, UPP2) into uracil and ribose 1-phosphate, where the ribose enters central carbon metabolism to support bioenergetics. Uracil, once considered waste, may have extracellular signaling roles.

Online Now: Uridine #trends #endocrinology #metabolism

Thanks for the highlight @frezzalab.bsky.social ! Check out our highlight on Uridine as the Metabolite of the Month in @cellpress.bsky.social ! @lyssiotislab.bsky.social 🧬

Thank you Federica!!!

Go Caleb!!!

Beyond grateful to share that my main PhD thesis project, Targeting PIKfyve-driven lipid metabolism in pancreatic cancer (@lyssiotislab.bsky.social + Arul Chinnaiyan lab), has just been published in @nature.com!

Proud to be a part of this important NIH funded work with @mckinnonwalsh.bsky.social, @bailey-bye.bsky.social and other colleagues from the @vansaunlab.bsky.social!

The @lyssiotislab.bsky.social and the Cancer Biology Program were out in full force at the One Day Closer to a Cure event. Annually, we host activities for high school students to learn about careers in cancer research and patient care. Special shoutout to Katie for an amazing patient story!

Yesterday, the House passed an FY25 budget bill that slashes funding to the Pancreatic Cancer Research Program by 57%.

Research for pancreatic cancer is already woefully underfunded, and now the only program exclusively funding pancreatic cancer research is one step closer to devastating cuts.

Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...

FLY EAGLES FLY 🦅🦅🦅

lab picture

defense picture

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Crazy that I defended on Friday! Really appreciate everything I learned from Yatrik and @lyssiotislab.bsky.social over the years! Can't ask for better mentors, labs, colleagues, friends, and support over the years!

Next step, postdoc with Kivanc Birsoy at Rockefeller University !🧿🗽

Super excited for @brandontwchen.bsky.social ‘s defense, but equally as sad to see him go 🫶🥲

Carrie would love some multiplex

Undergrads, looking for a summer research opportunity in cancer biology? Consider applying for a CARSIP position! Details below 👇🏼
Please [re] circulate widely 🔁!

Image of multiplex immunofluoresence staining

Getting some pretty IF images done with @mruckert.bsky.social on the @leicamicrosystems.bsky.social Stellaris before Thanksgiving break 🤩🍂