I'm excited to share our latest publication on co-transcriptional RNA folding in a eukaryote! Great work by Leo Schärfen with collaboration from Isaac Vock and Matt Simon! @leoschaerfen.bsky.social @mattdsimon.bsky.social
Take a peek here authors.elsevier.com/a/1kpxo_Oylr...

OpenSpliceAI: An efficient, modular implementation of SpliceAI enabling easy retraining on non-human species www.biorxiv.org/content/10.1101/2025.03....

RNA xkcd.com/3056

Yes, this is a huge problem. NIH was happy to fund model organism databases and OMIM in the early days, but now they're cup-in-hand, like Wikipedia.

Years ago, I got an NSF ABI (Advances in Biological Informatics) award (Sailfish, with Carl Kingsford) and then served on an ABI study section. It was an odd mix of things like funding the tidyverse and digitizing museum collections. I don't think they do exactly that any more, but they did.

"Children will die if RFK Jr. is put in charge of HHS."

RFK Jr. is not a serious person. Don't take him seriously. Well, president-elect Trump has announced that he will nominate Robert F. Kennedy Jr. to be the Secretary of Health and Human Services (HHS)...

A new blog post up today, my first since quitting @forbes. Read it here with no paywall or ads: genome.fieldofscience.com/2024/11/rfk-...

RNA sequencing depth guidelines for the study of alternative splicing A key parameter in the experimental design of RNA-seq projects is the choice of sequencing depth. Considering a limited budget, one needs to find a tradeoff between the number of samples and the sensi...

I feel like this is validation when people ask me about alternative splicing and then the first thing I ask them is their read depth...

RNA sequencing depth guidelines for the study of alternative splicing www.biorxiv.org/content/10.1...

Identification of coilin interactors reveals coordinated control of Cajal body number and structure This study identifies new Cajal body components and tests their roles in the formation of these nuclear membraneless organelles. Imbalances in the levels o

Published online today @jcellbiol.bsky.social you will find our latest work on Cajal bodies. 😅🎉 It has been a joy to work with Chuyue Zhang, Dahyana Arias Escayola, and colleagues! doi.org/10.1083/jcb....
#RNAsky #RNAbiology

My first post here.
So far, no garbage notifications or random turds in my feed.
I joined yesterday evening, followed 97 people, and now (10 am) 19 people I know have followed me back.
It looks like this is going to be like science Twitter in the old days.
😂