Great to see it out Selin! 👏

We are so excited to see our work out in @nature.com! We present a multi-omic single-cell atlas of 12 organs in human fetal development, explore the enhancer landscape, use deep learning to infer rules of transcription factor activity, and interpret non-coding variants in complex traits: #GeneReg 🧬🖥️

Great conference, great science and great location!

Maple syrup under a microscope.

That is why Canadians are so happy, we literally eat glitter. 😊

#Canada

The original Freaky Friday

Britain's most controversial farm track YouTube video by The Value of Nothing

Fresh off the press, my latest YouTube extravaganza, sponsored by the Wendover tourist board

The most important #RNA conference of the year with lots of amazing science and a really friendly atmosphere. This year in beautiful Montreal 🇨🇦 !

www2.rnasociety.org

Canada 🇨🇦 vs US 🇺🇸 Olympic gold medal final overtime

🐅

Congrats Michael!

Tetrad dissection

📣 The 2026 Midwest DNA Repair Symposium is coming to Kansas City (registration is open)

🗓 May 30–31, 2026

✨ Talks will be selected from abstracts, with a strong focus on trainees and new investigators.

Please RT & share with your labs!
🔗 sites.google.com/view/kumc-mi...

Great response so far for the DNA Repair Meeting in April 2026 ! 🧬

A few poster spots are still available.

✨ Early-bird registration extended to February 28th
✨ New invited speakers added: check the site: dnarepairmeeting-egmond2026.com

Don’t miss this outstanding meeting!

🤩

To all DNA repair aficionados 🧬 who want to attend the Egmond Repair Meeting in April 2026:

The deadline for early registration is January 10th, 2026! 🗓️

Sign up soon to benefit from the early-bird registration fee 🐦💸

See you all in Egmond! 🌊✨

That will be fun to explore!

Congrats Susi!

Figure showing overview of genetic search algorithm and evaluation strategy

How can we scale subcellular spatial proteomics across many experiments and conditions?

Our new paper presents a genetic algorithm and evaluation framework that optimizes bait subsets for proximity proteomics platforms like BioID enabling context-specific proteome mapping.

9 days to go:
* 2 x open positions!
* Exceptional environment, competitive start-up package
* University of Toronto appointments
* Toronto has great (and peaceful) quality of life!

A comprehensive genetic catalog of human double-strand break repair The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) w...

Kickstarting our Bluesky🦋 account with great news!
Our REPAIRome study finally out today in
@science.org
www.science.org/doi/10.1126/...

We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...

I suppose it is a calibration tool for food chemistry labs (calories, texture, content) but it's wild indeed!

I really wonder what a $2K set of peanut butter jars from the NATIONAL INSTITUTES OF STANDARDS & TECHNOLOGY could be for?

depmap miner logo

The Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data!
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.

Start mining data now: dataminer.depmap.sanger.ac.uk

Happy to share our latest research on the BRCA1-BRCTs now online.

academic.oup.com/nar/article/...

Congrats to first author Venda for putting it all together! This project was a great collaboration with the @titiasixma.bsky.social lab who helped us give structural meaning to our observations.

DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosis DNA double-strand breaks and unresolved DNA replication intermediates are particularly dangerous during mitosis. Paradoxically, cells inactivate canonical DNA repair mechanisms during chromosome segre...

Kaima Tsukuda and @andrewblackford.bsky.social have a highly complementary study that indicates that mutations in DDIAS (and CIP2A) caused neurodevelopmental defects, pointing a role for this pathway in development. /fin

www.biorxiv.org/content/10.1...

Thanks to all authors and collaborators, chiefly @yiboxue.bsky.social but that's not all!

Why is an ssDNA-binding protein involved in the CIP2A pathway? Our data suggests it may be to prevent ssDNA from accumulating in mitosis.

We propose that mitotic ssDNA is a liability for the integrity of chromosomes during cell division, and that a function of CIP2A-TOPBP1-DDIAS is suppress it.

We were puzzled by the fact that DDIAS has an OB-fold domain which often acts as an ssDNA-binding domain.

We find that DDIAS binds to ssDNA. This activity is not involved in its recruitment to DNA damage sites, but it is necessary for its function in genome maintenance.

Like CIP2A, DDIAS accumulates at DNA lesions specifically during mitosis, and it is recruited to the CIP2A-TOPBP1 complex via a phosho-dependent interaction with the TOPBP1 C-terminus.

DDIAS loss, like that of CIP2A, impairs the viability of BRCA1/2-deficient cells.