On this 1st April I'm happy to release a technical report from our startup MirageBio, describing a new protein structure model with state-of-the-art performance.

jgreener64.github.io/posts/techni...

Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍.
www.science.org/doi/10.1126/...
www.youtube.com/watch?v=gFE4...

Job opening for Research Group Leader in Structural Studies at MRC Laboratory of Molecular Biology, focusing on macromolecular structures.

Are you a structural biologist pushing the boundaries of molecular science with an ambitious research programme?
Join our Structural Studies Division as a tenure-track Group Leader, with core funding, world-leading facilities & enthusiastic colleagues.
Apply by 16 MAR
www.nature.com/naturecareer...

A portable orthogonal replication system enables continuous gene evolution near the biological speed limit www.biorxiv.org/content/10.64898/2026.02...

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳

mrc.tal.net/vx/mobile-0/...

Hey Charles! Thanks a lot!

Thanks Martin!!!

Thanks David! 💪

Thanks George!! 🤗

Star student & postdoc Kiarash Jamali is setting up his own group at the Ellison institute in Oxford. Join him for the most exciting machine learning research in structural biology and beyond!! 🤩 #ProudPI

Thank you! I’m excited

Thanks Alan!!!

a cartoon character in a bathing suit is standing on the beach ALT: a cartoon character in a bathing suit is standing on the beach

HAHAHAHAHA, I will never abandon Dr Zoidberg…

Join ML wizard Kiarash to develop BioML methods that work

Kiarash is starting his research group on computational enzyme design, get in touch with him if you want to be part of it.

Thank you Randy! Will keep you updated :)

Thanks Arjen!

PS if the link above doesn't work, please try jamali-lab-2.pages.dev

The GBI will be a fantastic place to do protein design research, with a large scale GPU cluster, expert wet lab biology groups, and a collaborative environment. For more information, please see jamalilab.com. If you are interested in a postdoc, please reach out, applications will be open soon.

GenBio DTP Optional supporting text

I’m excited to announce that I will be starting my research group on computational enzyme design at the Generative Biology Institute, Oxford, UK (@eitoxford.bsky.social)! PhD applications are open, deadline is Jan 8th (www.chem.ox.ac.uk/genbio-dtp). Email kiarash.jamali@eit.org with any questions!

And just when you thought things were settling down, the enigmatic Asgard archaea have another surprise in store! Cell cycle/life cycle stage-specific internal compartments with almost no eukaryote-derived clues as to how they might function.

Beautiful tomography and microscopy - congrats all 🤩

Incredible work!

An Asgard archaeon with internal membrane compartments

Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!

www.biorxiv.org/content/10.1...

Wilkinson Lab We discover and study reverse transcriptases

The Wilkinson Lab is open for science! @mskcancercenter.bsky.social

🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬

annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)

Cryo-EM maps and atomic models of the biotin-containing 3-methylcrotonyl-CoA carboxylase (MCC) complex and long-chain acyl-CoA carboxylase (LCC) complex

New lab preprint!
@zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes
🧵
tinyurl.com/ukny4ptz

We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.

mrc.tal.net/vx/appcentre...

If you are interesting in developing new algorithms for #cryoEM as a #PhD student or as a #postdoc, then do email or DM me. We have exciting opportunities coming up.

Could lithium stave off Alzheimer’s disease? The metal is depleted in brains of people with disease and can reverse memory symptoms in mice, new study shows

Researchers found that low lithium levels are linked to Alzheimer's disease in humans, and restoring it can reverse cognitive decline in mice. For a field still searching for cure, this paper may offer a clever new approach 🧠

Read more about it in @science.org
www.science.org/content/arti...

Glowing E. coli bacteria in green and blues on a background of DNA bases

Rewriting the language of life: Jason Chin’s group in the LMB’s PNAC Division have synthesised E. coli with just 57 codons instead of the usual 64.
Syn57 required 101000+ codon changes & represents a bold step towards programmable life.
Read more: www2.mrc-lmb.cam.ac.uk/syn57-repres...
#LMBResearch🧪

Good luck Martin! I’m sure you will do great 😊