Yes, and I meant that I wonder why “spontaneous” deamination was so easy

I’m sure a chemist could clear this up, but I never bother to ask

Protein PCR here we come!

The narrator Lockwood is a blockhead and I keep falling asleep during his dream sequence. Everyone he meets is mean and half the characters are named Catherine. Possible that I am the blockhead.

The great gatsby book cover

Wuthering heights book cover

I finish books, even ones I don’t enjoy, but there was one I just couldn’t get through: gatsby. Today, a second book makes the list: Wuthering heights. Why are these so popular ? I guess I’ll never know

Finally published at long last (at least in the pre-view version). Explore the wild and woolly world of archaeal histones! Interactive archaeal histone graph incluced rdcu.be/fdFjv. Congratulations to first author Shawn Laursen

Very pleased to say that the paper version of our study examining the role of de novo DNMTs in cancer-associated hypomethylation is now out in @plos.org Genetics 🎉:
doi.org/10.1371/jour...
You can read more on the previous thread but here is a summary of the main updates! #epigenetics 🧵 1/9

They’ll always be Sleepy and Coco and Chromo2 to me! Have a beer for me to celebrate a job well done 🍻

First first-author paper out! 🎉

We show that the classically repressive mark H3K27me3 can be linked to active transcription through a newly identified reader complex 🤯

Really grateful to everyone involved in this project during my PhD!

Thread below 👇

A H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium - Genome Biology Background The ability to deposit histone H3K27-trimethyl (me3) marks is essential for transcriptional repression by Polycomb Repressive Complex 2 (PRC2). This is largely attributed to Polycomb repres...

Our latest publication is now out at Genome Biology!
link.springer.com/article/10.1...

We uncover a unique association between a H3K27me3 reader complex and active transcription.
A thread with our key findings: (1/8)

#TEsky #Polycomb #transcription #smallRNAs

Based on chats w people from UdeM you need to adaptively sequence at least 3-5% of a human genome to reach sufficient complexity for good sequencing. Adding more samples wouldn’t help improve that % I think

Here's a little widget to play with the data across journals (as well as download the raw CSVs).

sashagusev.github.io/Genetics_Pub...

Want to know how histone marks regulate your favorite gene? Go single molecule with ChromSMF: integrated measure of chromatin accessibility and histone marks + DNA methylation, TF footprints and genotype for free! Very proud of @mpalamin.bsky.social ! @embl.org

Long reads carry multiple small vars and SVs and their phasing. LongcallD is the only caller that tightly integrates germline/mosaic small/structural vars/MEIs and their phasing in a single C program. One command line to get competitive small variant calls and better SVs. Led by Yan Gao.

Happy 30th birthday to this paper published March 22, 1996, one of the studies that moved chromatin biology from correlation toward mechanism. Brownell et al. linked a transcription-associated Tetrahymena HAT to yeast Gcn5p, providing a biochemical link for chromatin modification to gene activation.

If you consider 'hiring’ AI instead of a graduate student, you're saying the quiet part out loud: PhDs are viewed as a PI's labor force not academics studying for an advanced degree... www.science.org/content/arti...

We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).

Interestingly, your sentence didn't need to begin with that word.

Flyer for symposium: https://ctrlepiedit.sciencesconf.org/

Very excited to announce the FIRST symposium on epigenome editing! These tools are becoming widely used in mol bio, ag & therapy. It's time to bring leaders together to discuss this rapidly growing and exciting field. And why not in Paris! Please register & share! (1/2) ctrlepiedit.sciencesconf.org

I still put Bugonia in his top 3. I didn't like Marty Supreme at all, it's Uncut Gems but instead of dealing around with diamonds it deals with a dog??

Too low! The Stone/Plemons combo is too good

Bugonia #5 really Max?????????

Also I highly recommend Train Dreams

Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains Some proteins mimic the repressive mark H3K27me3, but the physiological relevance of this phenomenon was unclear. Agius et al. show that the PRC2 subunits JARID2 and PALI1 mimic H3K27me3 to antagonize...

1/ 🧵 In our new paper, we show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2. www.cell.com/molecular-ce...

Fantastic collaboration w/ @dbikard.bsky.social @audeber.bsky.social @rayanchikhi.bsky.social labs led by @jmouradesousa.bsky.social : We assessed the rates of variation of anti-phage systems in P4-like satellites and P2 helper phages. Quick conclusion: Huge variation! We focus on 4 key questions/5

🧵 Thread: What happens when transcription isn’t properly shut off during mitosis? Our new preprint explores just that 👇
www.biorxiv.org/content/10.6...

theonion.com/scientists-p...

🚨Preprint alert🚨 How does chromatin “architecture” form at CTCF sites? Our new preprint with @voslab.org and @andersshansen.bsky.social shows CTCF dimerization promotes nucleosome oligomerization on chromatin. tinyurl.com/CTCF-nucleos...

Loss of SETDB1-mediated H3K9me3 in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons Abstract. Heterochromatin is characterized by an inaccessibility to the transcriptional machinery and is associated with the histone mark H3K9me3. However,

New paper from my lab out in NAR. We found that young L1 elements are controlled by SETDB1 and H3K9me3 in human neural progenitor cells via a mechanism independent of HUSH and TRIM28/KZNFs.

academic.oup.com/nar/article/...

coffee karyotype

Mus pahari takes center stage! This looks fantastic and is going straight to the top of my to-read pile