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Germline polymorphisms in the immunoglobulin kappa and lambda loci underpinning antibody light chain repertoire variability - Nature Communications Antibody response variability contributes to differential individual responses and disease outcomes. Here authors show that genetic variation to the IG kappa and IG lambda loci is an important determi...

Happy to see this work on IG light chains from @e-engelbrecht1.bsky.social in press www.nature.com/articles/s41...
How else will germline variation impact the expressed repertoire? Can't wait to see!
Thanks to awesome collabs:
@williamlees.bsky.social @guryaari.bsky.social @ayeletperes.bsky.social

4 months ago 9 6 0 0
Image of the 2026 Immacantation Users Group Meeting Program. Available as text here: https://immcantation.github.io/users-meeting/2026/program.html

Image of the 2026 Immacantation Users Group Meeting Program. Available as text here: https://immcantation.github.io/users-meeting/2026/program.html

🧬Immcantation.org user or interested in #AIRRseq analysis to study infection, vaccination, clonal lineages & more? Join the 2026 Immcantation Users Group Meeting! 📅 Jan 22, 2026 ⏰ 10AM–1:30PM ET 💻 Free & Virtual
👉 Info: immcantation.github.io/users-meetin...
@immcantation.bsky.social #immunosky

4 months ago 1 2 0 1
VDJbase

Query by ancestry, tissue, chain, or study.

Explore allele usage, haplotypes, and gene presence/absence with interactive tools.

Download via API or browser.

Fully FAIR, MiAIRR-compliant, open, and versioned.

vdjbase.org

#AIRR #Immunogenetics

5 months ago 4 1 0 0

What’s new in VDJbase 2025?

• 3000+ human + macaque samples
• IGH, IGK, IGL, IGHC, TRB loci
• Matched AIRR-seq and genomic data
• Population-stratified genotypes + haplotypes
• Repertoire-based zygosity calls

#AIRR #VDJbase #Germline

5 months ago 1 0 1 0
Preview
The current landscape of adaptive immune receptor genomic and repertoire data: OGRDB and VDJbase Abstract. Accurate characterization of adaptive immune receptor repertoires through high-throughput sequencing is critical for understanding immune respons

New manuscript out in NAR! tinyurl.com/4rrbuesn
🧬 VDJbase and OGRDB now support 3000+ IG/TR samples across human and rhesus macaque with curated AIRR-seq and long-read genomic data. From population analysis to precision annotation. @guryaari.bsky.social @cdubsig.bsky.social @williamlees.bsky.social

5 months ago 8 4 1 0

Excited to see our work on IGHC diversity out! Huge shoutout to @uddalok.bsky.social for leading this study.

🧬 The data is now available on VDJbase, our open resource for exploring B and T cell germline variation across populations. 🧑‍🔬 Go and Explore vdjbase.org!

#immunogenetics #VDJbase

5 months ago 7 1 0 0
Post image

🚨 One week left! 🚨 Don’t forget to submit your 250-word abstract by October 1st! Share how you use Immcantation and contribute to building a supportive, collaborative research community. 🔗 2026 Immcantation Users Group Meeting immcantation.github.io/users-meeting/2026 #airrseq #immunosky

6 months ago 3 3 0 0
2026 Immcantation Users Group Meeting. Important information summary: Who: open to the public When: January 22nd, 2026 Time: 10:00 am - 1:30 pm ET Where: Virtual Fee: Free Abstracts due: October 1st, 2025 Final program: December 1st, 2025

2026 Immcantation Users Group Meeting. Important information summary: Who: open to the public When: January 22nd, 2026 Time: 10:00 am - 1:30 pm ET Where: Virtual Fee: Free Abstracts due: October 1st, 2025 Final program: December 1st, 2025

🚨 Immcantation.org user or interested in #Bcell repertoire analysis?
🗓️ Join the FREE virtual 2026 Immcantation Users Group Meeting
📅 Jan 22, 2026 | ⏰ 10AM–1:30PM ET
📢 Abstracts due Oct 1, 2025
🔗 immcantation.github.io/users-meeting/2026

#AIRRseq #Immcantation

7 months ago 6 5 0 1