Enzyme Inhibition Restores Neuron Pathways in a Parkinson's Mouse Model Inhibition of LKKR2 may rescue neurons that are dying due to a type of Parkinson’s disease that is caused by a single genetic mutation.

Enzyme Inhibition Restores Neuron Pathways in a Parkinson’s Mouse Model www.genengnews.com/topics/drug-... @asapresearch.parkinsonsroadmap.org #MJFF

While the political landscape leaves you without words (for the wrong reasons) the natural ones are a joy for the heart #USA #protecttheparks #protectscience

An advancement in lysosomal research with diagnostic applications!

Esther M. Sammler @ebagnoli.bsky.social & team present a tagless method for profiling lysosomal content from clinical samples: https://buff.ly/4kiVuu3

📣 Mark your calendars for Thursday, February 27! Andrew West from Duke University will present as part of our LRRK2 Central #webinar series. Reserve your spot below! #Neurosky

📅 February 27
⏰ 1:00 PM ET
RSVP: us06web.zoom.us/meeting/regi...

A great team effort and collaborative study made possible by @asapresearch.bsky.social and @lrrk2central.bsky.social . All raw data and protocols available in Zenodo and @protocolsio.bsky.social.

Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain | PNAS Mutations in Leucine-rich repeat kinase 2 (LRRK2) and PTEN-induced kinase 1 (PINK1) are associated with familial Parkinson’s disease (PD). LRRK2 ph...

Happy to share our new work on LRRK2 and PINK1 signalling in the brain. The two kinases appear to work on parallel pathway, but both converging on cilia. PINK1 KO animals have shorter and fewer cilia in striatal cholinergic interneurons and less GDNF.
www.pnas.org/doi/10.1073/...

Is anyone else starting to think that its all about cillia?

Researchers report PINK1 knock-out mice display cilia defects & reduced GDNF expression akin to LRRK2 mutant mice

A convergent mechanism for #Parkinsons?
www.pnas.org/doi/10.1073/...

📣 We are kicking off 2025 with a #LRRK2 webinar hosted by Luis Bonet Ponce, PhD from the Ohio State Department of Neurology at 1 pm ET. Mark your calendars!

📅 1/23
⏰ 1 pm ET
RSVP: us06web.zoom.us/meeting/regi...

Job Denali Therapeutics is dedicated to defeating neurodegenerative diseases through rigorous therapeutic discovery and development.

🚨New job post alert 🚨

We are looking to recruit a talented in vivo scientist to support our growing Parkinson's disease portfolio. Please reach out if you are interested in learning more!

www.denalitherapeutics.com/job?id=0844a...

LysoIP goes tagless. Happy to have contributed to this work funded by @asapresearch.bsky.social and @lrrk2central.bsky.social

📢 Exciting news: Our call for LOIs is OPEN for the CRN 2025 Scientific Track!

This #FundingOpportunity focuses on dissecting the mechanisms that can contribute to PD heterogeneity.

Be part of a global network pushing the boundaries of #ParkinsonsResearch.

Submit your LOI: bit.ly/3DXOBxt

Targeting mitophagy in neurodegenerative diseases - Nature Reviews Drug Discovery Impaired mitophagy leading to the accumulation of damaged mitochondria is associated with the onset and progression of neurodegenerative diseases. This Review provides an overview of the molecular pat...

Beautiful review on mitophagy in neurodegeneration from @odettaantico.bsky.social, @mmuqit.bsky.social.

www.nature.com/articles/s41...

Tomorrow is the day 📣

The first installment of the #mito911 webinar series, featuring Viktor Korochulk from the University of Newcastle, UK, will take place tomorrow at 11 am ET. It is not too late to reserve your spot - RSVP using the link below 🧪

us06web.zoom.us/webinar/regi...

Squid Game!

📣NEW FUNDING CALL: Early Career Development Fund 2025 🧑‍🎓

Aims to support researchers in their endeavours to develop their own independent academic research track 🚀

💰Apply for up to £4k!
📌 Call closes 24/02
💻 Join our information session to learn more: buff.ly/4j69lmR

Great to connect with fellow ASAP CRN members, PINK1 pathway to Parkinson's disease: 20 years on! @biochemsoc @asapresearch.bsky.social