Inflammatory signaling differentially changes #chromatin accessibility and #gene expression of the PD-associated kinase #LRRK2 between human and mice
Alexandra Beilina, Jae-Hyeon Park, Natalie Landeck...Mark R. Cookson @markrcookson.bsky.social #Parkinsons
link.springer.com/article/10.1...
#LRRK2 inhibitors found to enhance viral infection and oncolysis by oncolytic herpes simplex virus #therapy in #glioblastoma doi.org/10.1038/s414...
Italian scientists have established a significant connection between the #LRRK2 G2019S mutation, often associated with late-onset familial Parkinson's disease, and higher levels of clusterin in #astrocytes. 🔎
Learn more about the LRRK2-clusterin relationship on the blog 📍 https://bit.ly/4aH91XZ
GPNMB is a biomarker for lysosomal dysfunction and is secreted via LRRK2-modulated lysosomal exocytosis.
Bogacki, Erin C et al.
Paper
Details
#GPNMB #lysosomaldysfunction #LRRK2
Biomarkers of LRRK2 and lysosomal dysfunction in Progressive Supranuclear Palsy
Allinson, K. S. et al.
Paper
Details
#LRRK2 #lysosomaldysfunction #PSP
SciNeuro Pharmaceuticals Secures $5M to Advance Innovative Parkinson's Treatment Through MJFF Grant #United_States #Michael_J._Fox #Rockville,_MD #LRRK2 #SciNeuro
Seal Rock Therapeutics Collaborates with MJFF's LITE Program to Develop LRRK2 Therapies for Parkinson's Disease #USA #Seattle #Parkinson's_Disease #Seal_Rock #LRRK2
#LRRK2 kinase activity regulates #Parkinsons disease-relevant #lipids at the #lysosome
Michael T. Maloney, Xiang Wang...Anastasia G. Henry
molecularneurodegeneration.biomedcentral.com/articles/10....
ERM phosphorylation is impaired in PD patients carrying LRRK2 G2019S mutation.
CRN Team Calakos found that a #LRRK2 G2019S mutation enhances the phosphorylation of ERM proteins in PAP, which is accompanied by decreased astrocyte morphological complexity & reduced excitatory synapse density & function.
🔗 Read their #preprint: www.biorxiv.org/content/10.1101/2023.04.09.536178v4
📣 We are excited to welcome Susanne Herbst, PhD, from the University of London, as the May #LRRK2 Central webinar speaker. Mark your calendars and use the link below to reserve your spot.
🗣️ Susanne Herbst, PhD, from the University of London
📅 May 22
⏰ 1:00 PM ET
RSVP: bit.ly/42M9Dcp
How does the environment impact Parkinson’s disease penetrance—even in people with genetic mutations? We studied over 80k people to find out.
mattkmiecik.substack.com/p/parkinsons...
#Parkinsons #ScienceCommunication #Epidemiology #LRRK2
CaV1.3 channels are vital for dopamine neuron function. We found that mutant LRRK2 (G2019S) enhances their activity via CaVβ3 phosphorylation, a potential key factor in Parkinson's disease. #neuroscience #ionchannels #ParkinsonsDisease #LRRK2 #CaV1.3 www.mdpi.com/1422-0067/26...
Thoughts on this? >> Neuron23 to Present Phase 1 Healthy Volunteer Data of
NEU-411, a Brain-penetrant LRRK2 Inhibitor, at AD/PD™ 2025: SOUTH SAN FRANCISCO, Calif.–(BUSINESS WIRE)–#LRRK2–Neuron23® Inc., a clinical-stage biotechnology… >> Comment below! #AI #healthtech #mhealth #industry40 #IoT
Understanding #Parkinsons subtypes is key to more targeted RCTs & better therapeutics! 🧠 Our new study finds that LRRK2 PD patients show milder cortical atrophy, with preserved temporal & occipital regions compared to sporadic PD. #LRRK2 #dataviz
www.medrxiv.org/content/10.1...
📣 We are kicking off 2025 with a #LRRK2 webinar hosted by Luis Bonet Ponce, PhD from the Ohio State Department of Neurology at 1 pm ET. Mark your calendars!
📅 1/23
⏰ 1 pm ET
RSVP: us06web.zoom.us/meeting/regi...
It’s exciting to see more and more studies coming in that use our recently launched Aurora Rapid 8x150 columns. In a new highlight, Heaton et al. investigate the role of LRRK2 mutations in Crohn's disease (CD) and Parkinson's disease (PD).
Learn more: bit.ly/3Z36Zfc
#LRRK2 #CrohnsDisease
Great new study from Liu lab @WUSTL dissecting the interaction between #autophagy, cigarette smoke, and #IBD risk mutations #LRRK2 #ATG16L1 driving Paneth cell defects through macrophages www.science.org/doi/10.1126/...
Mark your calendars! Make sure to join us on Thursday, Oct. 24 at 1 pm ET for this month's installment of the #LRRK2 Central webinar series with Esther Sammler from the University of Dundee.
Reserve your spot: stanford.zoom.us/meeting/regi...
Today the LRRK2 Central Seminar will feature a talk by Ji Sun on the structure-function relationship of #LRRK2 activation as well as the insights gained from high-resolution structures for future drug design. 🧪
stanford.zoom.us/meeting/regi...
