ATG16L1 controls mammalian vacuolar proton ATPase Duque et al. report a hitherto unappreciated function of ATG16L1, best known for its roles in canonical autophagy and membrane atg8ylation, in directly reg

Prior studies show that #Lysosome proton pump V-ATPase interacts with #ATG16L1, an #autophagy factor, to direct membrane #atg8ylation upon damage. A new study shows the reverse - ATG16L1 inhibits V-ATPase.

ATG16L1 controls mammalian vacuolar proton ATPase url: rupress.org/jcb/article-...

Everyone interested in #autophagy knows that #ATG16L1 is an E3 ligase for membrane #atg8ylation sometimes directed by V-ATPase. A new study shows the reverse - that ATG16L1 inhibits V-ATPase.
ATG16L1 controls mammalian vacuolar proton ATPase rupress-org.libproxy.unm.edu/jcb/article-ab…

The Role of WIPI2, ATG16L1 and ATG12-ATG5 in Selective and Nonselective Autophagy Autophagy is a conserved cellular recycling pathway that delivers damaged or superfluous cytoplasmic material to lysosomes for degradation. In respons…

Thrilled to share my latest review on the role of the #WIPI2 and #ATG16L1 complex in both selective and nonselective #autophagy 🔍🧬 It’s fascinating how these two forms of autophagy rely on the same core machinery, yet lead to such different outcomes. What defines this divergence? Have a look here 👀

Great new study from Liu lab @WUSTL dissecting the interaction between #autophagy, cigarette smoke, and #IBD risk mutations #LRRK2 #ATG16L1 driving Paneth cell defects through macrophages www.science.org/doi/10.1126/...