Autophagolysosomal exocytosis inverts Src kinase onto the cell surface in cancer Overexpression of the proto-oncogene Src is common to a wide variety of cancers. In this work, we found that Src is noncanonically translocated and inverted onto the cell surface in cancer, both in vi...

This week #JournalClub @labsoap.bsky.social
#Src #lysosome #autophagy #exocytosis welcome to the upside-down 😱 @science.org www.science.org/doi/10.1126/...

The #autophagy protein ATG-9 regulates #lysosome function and integrity. From Kangfu Peng, Hong Zhang and colleagues (Institute of Biophysics, CAS): rupress.org/jcb/article/...

📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#GRC

A lysosomal requiem for glioblastoma cells Once viewed solely as degradative compartments, lysosomes shape cell fate through signaling, metabolism, and communication. In glioblastoma, their rew…

take a look to our #forum on #lysosome #glioblastoma out @cp-trendscancer.bsky.social

🧠 "A lysosomal requiem for glioblastoma cells"

lnkd.in/e3Zcb46y

🙌 Laura Merlet Margaux LE GUYON Julie Gavard

www.sciencedirect.com/science/arti...

Ferroptosis induces heterogeneous death profiles that are controlled by lysosome rupture Ferroptosis is a lipid peroxide-dependent form of cell death that occurs in degenerative conditions and may be leveraged for cancer therapy. Although …

Ferroptosis induces heterogeneous death profiles that are controlled by #lysosome rupture www.sciencedirect.com/science/arti...

I’ve officially started my lab at Monash University! 🎉

We’re diving into #cellgrowth and #lysosome biology, through the lens of molecular #structure and mechanism.

I’m thrilled to say that PhD student scholarships are available—so please share widely and get in touch if you’re interested. 🤩

New year resolution to post more! Proud of @yushengyeh & @RazaniLab members for their ATVB review this month comparing/contrasting newly discovered #adipocyte #lipolysis via #lysosome #LIPA vs. known cytoplasm #ATGL in #cardiometabolic #CVD 💪
www.ahajournals.org/doi/10.1161/...

The #autophagy protein ATG-9 regulates #lysosome function and integrity. From Kangfu Peng, Hong Zhang and colleagues (Institute of Biophysics, CAS): rupress.org/jcb/article/...

📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#KSAutophagy26

TFEB ameliorates DEHP‐induced neurotoxicity by activating GAL3/TRIM16 axis dependent lysophagy and alleviating lysosomal dysfunction Di-(2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer with known neurotoxic effects. However, the specific mechanism underlying this neurotoxicity remains unclear. This study aimed to inv...

#lysosome #ecotoxicology #aging #geriatrics #health #exposome #Alzheimers #neurology #phthalates

DEHP causes lysosomal dysfunction.
onlinelibrary.wiley.com/doi/abs/10.1...

Toxic metals
reduce lysosomal membrane stability
and increase lipofuscin.
www.int-res.com/articles/mep...

Plasma membrane-to-lysosome FGR signaling regulates #endocytosis-associated #lysosome homeostasis, say Qiuyuan Yin, Chonglin Yang and colleagues (Yunnan University): rupress.org/jcb/article/...

#Organelles #Lysosomes

In @jcb.org, Qiuyuan Yin, Chonglin Yang et al. reveal a plasma membrane-to-lysosome signaling pathway mediated by the non-receptor tyrosine kinase FGR and the serine/threonine kinase AKT2, which regulates TFEB/TFE3 activation for #lysosome biogenesis in #endocytosis. rupress.org/jcb/article/...

Qiuyuan Yin, Chonglin Yang et al. reveal a plasma membrane-to-lysosome signaling pathway mediated by the non-receptor tyrosine kinase FGR and the serine/threonine kinase AKT2, which regulates TFEB/TFE3 activation for #lysosome biogenesis in #endocytosis. rupress.org/jcb/article/...

#Organelles

Maspardin/SPG21 controls #lysosome motility and TFEB phosphorylation through RAB7 positioning, say Thomas Jacqmin, Marielle Boonen and colleagues (University of Namur): rupress.org/jcb/article/...

#Trafficking #Organelles #Disease

Jacqmin, Boonen et al. report that the loss of maspardin, which is deficient in spastic paraplegia 21, results in RAB7 hyperactivation due to mislocalization. This abnormal RAB7 localization leads to defects in #lysosome #trafficking & disruption of the mTOR–TFEB pathway. rupress.org/jcb/article/...

Happy #MicroscopyMonday from our brilliant team recently at #CellBio25 Booth no. 416!

#scienceconference #sciencetravel #sciencecollaboration #labhelp #scienceconnections #nanobodies #livecellimaging #mitochondria #lysosome #microtubule #fixedcells #cellularimaging #microscopy

Having seen how hard they worked for this publication really makes me so happy for them to see the result.
Really fascinating work, do give it a read

#cellbiology #cell #lysosome #nature

Bentley-DeSousa, Roczniak-Ferguson and @shawnferguson.bsky.social reveal converging roles of STING and #lysosome damage in activating LRRK2 at #lysosomes via interactions between LRRK2 & GABARAP rupress.org/jcb/article/...

📕 From The Year In Cell Biology: rupress.org/jcb/collecti...
#CellBio2025

MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death - Nature Cell Biology Nguyen, Collier et al. find a mitochondria–lysosome inflammatory pathway regulated by the SUMO E3 ligase MAPL, which promotes vesicular mtDNA transport to lysosomes and subsequent gasdermin-dependent ...

☕Nguyen, Collier et al. find a #mitochondria – #lysosome inflammatory pathway regulated by the SUMO E3 ligase MAPL, which promotes vesicular mtDNA transport to lysosomes and subsequent gasdermin-dependent lysosomal permeabilization to activate #pyroptosis.
bit.ly/4oF4Fqb

LYVAC/PDZD8 is a lysosomal vacuolator Lysosomal vacuolation is commonly found in many pathophysiological conditions, but its molecular mechanisms and functions remain largely unknown. Here, we show that the endoplasmic reticulum (ER)–anch...

This week #JournalClub @labsoap.bsky.social @science.org #LYVAC #vacuole #lysosome www.science.org/doi/10.1126/...

Fantastic and productive meeting with the labs of Tamotsu Yoshimori, Shuhei Nakamura, Akiko Kuma at #Osaka University. Discussing perspectives of #microautophagy in th #lysosome regeneration after damage. Thanks so much for hosting me.

Meeting new and old friends at the JPS conference in Kyoto, Japan. Presented our newest data on the #Lysosome Damage Response. #ATXN3 Thanks to the organizers.

CNPN and HUPO will be held on November 8th!

This is our honor to have our keynote and invited speakers 🤩
@kislingerthomas.bsky.social and Dr. Ling Hao

For more info about the program: cnpn.ca/cnpn2025/

#HUPO #proteomics #Lysosome #biomarkerdiscovery #therapeutictargets #humannuerons

Proteomics Insights Into Lysosome Biogenesis and Maturation Lysosomes constitute the main degradative organelle of most eukaryotic cells and are capable of breaking down a wide spectrum of biomolecules, including proteins, lipids, glycans, and DNA/RNA. They p....

Proteomics Insights Into #Lysosome Biogenesis and Maturation analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...

Client Challenge

This week #journalclub @labsoap.bsky.social @naturemetabolism.bsky.social @agostinislab.bsky.social #Lysosome #ferroptosis #mitochondria www.nature.com/articles/s42...

In @jcb.org, @lysoluis.bsky.social, @markrcookson.bsky.social et al. show how two distinct pRAB effectors and RHD members, JIP4 and RILPL1, provide antagonistic motor force to regulate #lysosome tubulation. rupress.org/jcb/article/...

@lysoluis.bsky.social, @markrcookson.bsky.social et al. show how two distinct pRAB effectors and RHD members, JIP4 and RILPL1, provide antagonistic motor force to regulate #lysosome tubulation. rupress.org/jcb/article/...

Online now - the Forum "The interplay of the cGAS–STING pathway with the lysosome" from Yinfeng Xu and Wei Wan.

#InnateImmunity #Lysosome #cGASSTING

Read it here: authors.elsevier.com/a/1lpuN_M0e4...

ATG16L strikes again! New findings link #lysosome stress and physiology. Alison Klein and Michael Overholtzer @mskcancercenter.bsky.social discuss new study from @thabataduque.bsky.social et al. of the Deretic group (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/...

Bridge-like lipid transfer protein 3A (BLTP3A) participates in endomembrane repair as an effector of #ATG8 conjugation to single membranes (CASM) - helping repair or minimize #lysosome damage
@mike-hanna.bsky.social et al, @pdc-lab.bsky.social
www.embopress.org/doi/full/10....

ATG16L1 controls mammalian vacuolar proton ATPase Duque et al. report a hitherto unappreciated function of ATG16L1, best known for its roles in canonical autophagy and membrane atg8ylation, in directly reg

Prior studies show that #Lysosome proton pump V-ATPase interacts with #ATG16L1, an #autophagy factor, to direct membrane #atg8ylation upon damage. A new study shows the reverse - ATG16L1 inhibits V-ATPase.

ATG16L1 controls mammalian vacuolar proton ATPase url: rupress.org/jcb/article-...

Targeting phospholipase PLAG-15 promotes healthy aging in C. elegans via lysosomal-related genes Molecular physiology; Lipidomics; Transcriptomics

Check out our newly published paper at IScience! We showed that knocking down a fat-processing enzyme gene, plag-15, can switch on lysosome programs and extend lifespan in worms! cell.com/iscience/ful...
#Healthyaging #lysosome #Celegans