ATG16L1 controls mammalian vacuolar proton ATPase Duque et al. report a hitherto unappreciated function of ATG16L1, best known for its roles in canonical autophagy and membrane atg8ylation, in directly reg

Prior studies show that #Lysosome proton pump V-ATPase interacts with #ATG16L1, an #autophagy factor, to direct membrane #atg8ylation upon damage. A new study shows the reverse - ATG16L1 inhibits V-ATPase.

ATG16L1 controls mammalian vacuolar proton ATPase url: rupress.org/jcb/article-...

Everyone interested in #autophagy knows that #ATG16L1 is an E3 ligase for membrane #atg8ylation sometimes directed by V-ATPase. A new study shows the reverse - that ATG16L1 inhibits V-ATPase.
ATG16L1 controls mammalian vacuolar proton ATPase rupress-org.libproxy.unm.edu/jcb/article-ab…

Duque et al @unm.edu show that a core membrane #atg8ylation & #autophagy factor ATG16L1 controls proton V-ATPase under homeostatic conditions, ensuring normo-acidification, preservation of cellular energy charge & function, & defense against #tuberculosis in murine models rupress.org/jcb/article/...

Keeping your endosymbiont under control: the enigmatic plastid membrane ATG8ylation in Apicomplexa parasites ATG8ylation of membranes has been increasingly reported over the last few years, in various configurations and across different eukaryotic models. While the unconventional conjugation of ATG8 to th...

I finally found the time to write a short piece on ATG8ylation of the apicoplast. You may want to check it out here: www.tandfonline.com/doi/full/10....
#autophagy #ATG8ylation #apicoplast

Balancing the pressure: How plant cells protect their vacuoles Plants droop and shed their leaves when parched, but with a splash of water, their stems regain strength and their leaves unfurl. This dramatic transformation is a clear signal for us to reach for the...

Balancing the #pressure: How #plant #cells protect their #vacuoles.

#turgidity #ATG8 #ATG8ylation #membrane

phys.org/news/2025-02...

ATG8ylation of vacuolar membrane protects plants against cell wall damage - Nature Plants ATG8ylation of the tonoplast, triggered by cell wall damage, acts as a vital vacuolar quality control mechanism that safeguards vacuolar integrity and ensures cell survival under stress.

Happy to see that our Cell wall integrity #CWI & #ATG8ylation #preprint found a home @natureplants www.nature.com/articles/s41... Congrats Jose, Peng, Alessia & everyone involved. Stay tuned for exciting updates on this story…

#ATG8 is a #ubiquitin like protein that is central to selective autophagy. It can also be conjugated to various single membranes, aka #ATG8ylation