Independent nuclear and organellar mechanisms determine #apicoplast fate in #malaria #parasites, say Michal Shahar, Anat Florentin et al. @florentin-lab.bsky.social
rupress.org/jcb/article/...

In @jcb.org, Michal Shahar, Anat Florentin et al. @florentin-lab.bsky.social reveal how the #malaria parasite's #apicoplast develops through four distinct stages linked to nuclear replication, including a unique “Crown” stage critical for organelle inheritance rupress.org/jcb/article/...

Michal Shahar, Anat Florentin et al. @florentin-lab.bsky.social reveal how the #malaria parasite's #apicoplast develops through four distinct stages linked to nuclear replication, including a unique “Crown” stage critical for organelle inheritance rupress.org/jcb/article/...

Phenotypical characterization of novel apicoplast membrane proteins in Toxoplasma gondii - One Health Advances As a critical organelle in Toxoplasma gondii, an important zoonotic pathogen, the apicoplast plays a vital role in survival by hosting essential metabolic pathways. Its unique four-membrane structure ...

Breaking Research: New study identifies HAP1 and HAP9 as indispensable apicoplast membrane transporters ensuring Toxoplasma gondii survival in vitro and in vivo!#Toxoplasma #Apicoplast

Key targets for understanding apicomplexan biology!
🔬 Read:
onehealthadv.biomedcentral.com/articles/10....

Drs Laura Akkerman, Taco Kooij & Laura de Vries review the #apicoplast #transportome of the #malaria parasite. #Plasmodium #Transporter @radboudumc.bsky.social‬

authors.elsevier.com/a/1lRRT5Eb1x...

What keeps Toxoplasma gondii’s apicoplast functioning? A newly identified protein, TgGloL, may be key. Though it resembles a glyoxalase, TgGloL plays a unique role in parasite growth and organelle stability. www.molbiolcell.org/doi/10.1091/... #ASCB #Parasites #CellBiology #Apicoplast #Toxoplasma

Take-home message:
PfAnchor is essential for apicoplast fission and inheritance in malaria parasites. Targeting this process could open up new avenues for antimalarial therapies!
Check out the full story and let us know what you think!
#U_ExM #malaria #cellbiology #apicoplast #parasites #preprint

An Essential Adaptor for Apicoplast Fission and Inheritance in Malaria Parasites Blood-stage Plasmodium falciparum parasites rely on a non-photosynthetic plastid, the apicoplast, for survival, making it an attractive target for antimalarial intervention. Like the mitochondrion, th...

🚨 New preprint alert! 🚨
We’ve uncovered a key player in malaria parasite cell division—meet PfAnchor, the first apicoplast-specific dynamin adaptor protein! Check the thread below 🧵for more details. #U_ExM #Malaria #Apicoplast
www.biorxiv.org/content/10.1...

Keeping your endosymbiont under control: the enigmatic plastid membrane ATG8ylation in Apicomplexa parasites ATG8ylation of membranes has been increasingly reported over the last few years, in various configurations and across different eukaryotic models. While the unconventional conjugation of ATG8 to th...

I finally found the time to write a short piece on ATG8ylation of the apicoplast. You may want to check it out here: www.tandfonline.com/doi/full/10....
#autophagy #ATG8ylation #apicoplast

These 4 enzymes have been included in all the minimal translation machinery concepts proposed to date. The discovery of only these 4 enzymes in #apicoplast of #Plasmodium puts us a step closer to our big picture of establishing apicoplast as minimal translation model.

Before going in to details, interesting fact! #apicoplast genome contains the minimal complete set of tRNAs among all known living systems, making it a #good #model to study minimal #translation system. We intend to establish that.

xm5s2U #tRNA modification is crucial for proper protein #translation, especially in a translation system with minimal components. We have described the players of xm5s2U34 biosythesis in #Plasmodium #apicoplast. Read the story to find out why parasites need this and how we did it. 1/6