#GPNMB is a key #biomarker of #metabolic disorders — but what is its role in adaptation to #obesogenic diets? With help from a FoxBox #Respirometry System, scientists showed that GPNMB inactivation disrupts diurnal #hepatic glycogen #metabolism.

buff.ly/OcRp6jb

#Obesity

GPNMB is a biomarker for lysosomal dysfunction and is secreted via LRRK2-modulated lysosomal exocytosis.
Bogacki, Erin C et al.
Paper
Details
#GPNMB #lysosomaldysfunction #LRRK2

老化細胞 targeted: NPTによる新規GPNMBペプチドの発見と特許出願 医薬分野の革新が進む中、株式会社NPTが新たに発見したGPNMB由来のペプチドに関する特許出願。老化細胞の除去に期待が寄せられています。

老化細胞 targeted: NPTによる新規GPNMBペプチドの発見と特許出願 #株式会社NPT #GPNMB #医療創薬

医薬分野の革新が進む中、株式会社NPTが新たに発見したGPNMB由来のペプチドに関する特許出願。老化細胞の除去に期待が寄せられています。

NPT Corp. Files Patent Application for New Therapeutic Approach Targeting Senescent Cells NPT Corp has filed a patent for a novel peptide targeting senescent cells to combat age-related diseases and enhance therapeutic options.

NPT Corp. Files Patent Application for New Therapeutic Approach Targeting Senescent Cells #Japan #Koto #GPNMB #NPT_Corp #senescent_cells

新しい治療法を目指す！老化細胞を狙った特許出願の背景とは 株式会社NPTが特許を出願した医薬組成物に注目。老化細胞を選択的に除去する新たなアプローチに感心が高まる。

新しい治療法を目指す！老化細胞を狙った特許出願の背景とは #東京都 #江東区 #株式会社NPT #GPNMB #医療・創薬

株式会社NPTが特許を出願した医薬組成物に注目。老化細胞を選択的に除去する新たなアプローチに感心が高まる。

Thanks for amplifying the excellent work spearheaded by Rebecca Wallings & team on roles of #Gpnmb & #Grn in peripheral immune cell function

Acquired resistance to immune checkpoint therapy is caused by glycoprotein non-metastatic melanoma protein B signal cascade - Communications Medicine Chung et al. examine the levels of glycoprotein non-metastatic melanoma protein B (GPNMB) in the blood of patients with renal cell carcinoma who acquire resistance to immune checkpoint inhibitor therapy. Findings show that GPNMB levels are elevated and could serve as a prognosticator of and potential treatment target for treatment-resistant cancer.

⚕️ NEW RESEARCH! 🩺

Chung et al. find that elevated levels of #GPNMB could serve as a prognosticator of immune checkpoint inhibitor (ICI) treatment-resistant kidney cancer.

https://bit.ly/3EhH1y2
#CancerResearch #Immunotherapy

11/13 While promising, some senescent cells are beneficial, like in wound healing. An "aging vaccine" using GPNMB aims to selectively remove harmful senescent cells. #GPNMB #AgingVaccine #WoundHealing