Effects of Janus kinase inhibitors in adults admitted to hospital due to COVID-19: a systematic review and individual participant data meta-analysis of randomised clinical trials This IPDMA of RCTs in adults admitted to hospital due to COVID-19 found that JAK inhibitors reduced mortality across all levels of respiratory support, independent of dexamethasone or tocilizumab, and...

With over 96% of global trial data on this topic included, this #IPDMA, published in @lancetrespirmed.bsky.social and initiated by #EU-RESPONSE, provides the most comprehensive analysis for JAK inhibitors for adults hospitalized due to #COVID19.

Full article: www.thelancet.com/journals/lan...

AfD classified as extreme-right by German intelligence The AfD came second in February elections and has a record number of seats in the new parliament.

Finally!
www.bbc.com/news/article...

I’m thrilled that leading research groups now recommend our #ICEMANtool to evaluate possible subgroup effects:
#Cochrane in their handbook Chapter 10.6
#GRADE in their guidance No. 36
Germany's #IQWIG in their general methods
www.iceman.help
www.cmaj.ca/content/192/...

a man with a beard is sitting in a room with a harp in the background ALT: a man with a beard is sitting in a room with a harp in the background

Ian Fleming's original James Bond novels haven't aged well. For example, Moonraker - published almost exactly 70 years ago in April 1955 - features a villain who's a super-rich industrialist and rocket-maker seeking to cause chaos because he's a secret Nazi. Such a silly idea!

Hi @bmj.com
Can you add a Bluesky share button instead of the X button you have please?

Airbnb’s co-founder is joining Elon Musk’s DOGE Gebbia, a close friend of Musk, has praised DOGE’s work and defended it against criticisms on social media

Time to evict AirBnB from your life, if you have't already.

Have you checked our risk-stratified #RapidRecs on #PCSK9 inhibitors and #ezetimibe for the reduction of cardiovascular events ?
@magicevidence.bsky.social @bmj.com
-->https://www.bmj.com/content/377/bmj-2021-069066

The risks of backing scattered islands of sensible points in a sea of nonsense: kucharski.substack.com/p/islands-of...

Health in the age of disinformation Health misinformation (false or misleading data shared unintentionally) and disinformation (deliberately deceptive information) are not new, but the COVID-19 pandemic marked a turning point. The sense...

www.thelancet.com/journals/lan...

What advice can we offer to authors? Reflections from the statisticians’ bench What are the statistical issues on which the Journal of Clinical Epidemiology editorial team should be offering advice to authors? Lists of statistical bugbears and elephant traps in health research r...

J Clin EPi @jclinepi.bsky.social has a unique focus on meta-research. I've co-led a November editorial reflecting on the variety its content, and how an even richer balance might be achieved. Methodologists assemble! www.jclinepi.com/article/S089... @davidit.bsky.social @andreatricco.bsky.social

So true!

A better statistic might be the prediction interval but in my view the community needs to develop more experience with it before we can use it to confidentially judge relevance of heterogeneity (if ever). And unfortunately it does not work very well in a meta-analysis with only a few studies

True. But what else can we do? A paper in the new Core GRADE series (currently under revision in the BMJ) offers a practical solution based on visual inspection of both overlap of confidence intervals (similar to I2) but also where point estimates lie in relation to a relevance threshold.

Numerical coincidences for 2025 There seem to be a lot of numerical coincidences bouncing around concerning the new year 2025. For example, it’s a square number: \( 2025 = 45^2 \). The last square year was \(44^2 = 1936\), …

Happy New Year! I wrote a list of numerical coincidences involving 2025, see if you spot something fun!

#MathsSky #MathSky #MathsToday #MathChat

Why I believe the mistreatment of women is the number one human rights abuse With his signature resolve, former US President Jimmy Carter dives into three unexpected reasons why the mistreatment of women and girls continues in so many manifestations in so many parts of the wor...

www.ted.com/talks/jimmy_...

Getting Ready for More mRNA Vaccine Fear-Mongering: A Compendium - Absolutely Maybe Recently, I wrote about a depressingly successful campaign against the introduction of a next generation Covid vaccine in Japan. It is a…

Ever wonder about the basis for fear-mongering & conspiracy theories about mRNA vax? Wish you had a place to go when someone cites "proof"?

I've got you covered! In my latest @plos.org I buckle up for the waves of anti-vax muck likely to come in 2025. 1/2

absolutelymaybe.plos.org/2024/12/28/g...

The case for clinical trial abundance A supply-side reform agenda for one of our most urgent problems

1/ Excited to share thoughts on two excellent blog posts about clinical trials! First up: "The Case for Clinical Trial Abundance" by @ruxandrabio.bsky.social and Willy Chertman . They argue we need more clinical trials & that bureaucracy hampers faster progress. A sentiment I fully share!

The image is a graph titled "Reported paralytic polio cases and deaths, United States, 1910 to 2019," from Our World in Data. It shows the annual number of polio cases (in red) and deaths (in green). A sharp decline in both cases and deaths occurs after the introduction of the polio vaccine in 1957, which is marked with an arrow labeled "Vaccine introduced in 1957." The graph illustrates the dramatic impact of vaccination on reducing polio cases and fatalities over time.

Vaccines stopped polio.

Methods guidance is evolving. Here the authors chose to provide explicit recommendations both in favor but also agains certain methods. I think that that’s the way forward!

Great! Will include it in @lightsdatabase.bsky.social

Does #randomization ensures balance of risk factors between groups? Consider this:

In Denmark 860 individuals were randomly allocated to either intervention or control. Individuals were unaware of their allocation. No intervention took place. Mortality was higher in the intervention group (p=0.003)

This is leadership

Launching this week, MetaROR will be a free, open platform where anyone working with metaresearch can share their work and receive transparent, open peer reviews.

Join us at one of our launch events to find out more: researchonresearch.org/metaror-laun...

A podcasting highlight!

Thanks so much to Editor-in-Chief of Science @holdenthorp.bsky.social for such a generous interview - calling for increased HPS teaching across high school and uni science curricula

Check the ep out on the pod today!

#hps #sts #histstm #philsci #academicsky #metasci

What a talent. RIP Quincy Jones.

Hi qualitative researchers!

For my teaching, I was searching for something like PICO for qualitative. I found SPIDER and like it! pubmed.ncbi.nlm.nih.gov/22829486/

Is anybody aware of any other scheme for systematic question / problem / objective formulation in a qualitative study?

Sorry, what was the question again? And again. And again. And again...

For patient-focused research, there are very few useful research aims, and none of them are "identifying risk factors.”

Seriously! 😜

(ICYMI)

statsepi.substack.com/p/sorry-what...

Homepage - LIGHTS The Library of Guidance for Health Scientists. A living database for methods guidance.

Did you just present new #TrialsMethodology guidance at #ICTMC2024? Have a look at our new database and check whether it is already in it. If not, send it along!
lights.science

Fully agree there’s a need