Nice paper from Kota @saitolab.bsky.social! Balanced phosphorylation of TANGO1 and Sec16A keep ER exit sites stable and functional.
Do cells maintain this dynamically to keep secretory machinery primed and responsive to changing cargo loads or environmental signals?
www.nature.com/articles/s41...

The fate of mitochondrial respiratory complexes in aging While mitochondrial dysfunction is one of the canonical hallmarks of aging, it remains only vaguely defined. Its core feature embraces defects in energy-producing molecular machinery, the mitochondria...

www.cell.com/trends/cell-...

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...

SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: “Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...

I am looking for a post/doc! Are you motivated to study the fundamental questions in autophagy? Have a look!

Lovely to see the JCS best paper prize renamed in honor of David Stephens, a fantastic cell biologist the world lost far too soon #biologists100

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...

An incredible tour de force in biochemistry and cell biology by superstar @robzonculab.bsky.social lab postdoc @aakritijain.bsky.social
LyLAP - a new lysosomal protease responsible for degrading integral membrane proteins in highly phagocytic cells like #PDAC cells.
www.science.org/doi/10.1126/...

Amazing science, with fantastic people at beautiful location of #EMBOcellBio24 Annaberg Workshop "From Molecules to Organisms".

The pathways of secretory cargo export at the endoplasmic reticulum Nature Communications - The author presents an overview of the complex challenge of protein export from the Endoplasmic Reticulum, and discusses how cells may deploy novel pathways utilizing...

A terrific perspective from Vivek Malhotra @naturecomms.bsky.social on the fundamental importance of pathways and mechanisms by which cells secrete proteins, ensuring their delivery in the correct quantities and at the appropriate times.
Interesting section on unanswered questions.

rdcu.be/ecb2B

We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....

Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites - Nature Communications Protein-mediated transport is implicated in trafficking fatty acids at contact sites of lipid droplets and mitochondria. Here, the authors use proteomics to catalogue the proteins at this contact site...

Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites
www.nature.com/articles/s41...