Graphical abstract showing that NMDAR immunisation drives psychosis-like behaviour in mice, while clozapine reverses this. Upper panel: arrows show NMDAR immunisation producing a mouse exhibiting psychosis-like behaviour, with clozapine reversing this effect. Lower panels: anti-NMDAR antibodies bind neuronal NMDA receptors, which are then eliminated by microglia via phagocytosis, leading to psychosis. Clozapine restores NMDA receptor levels by reducing anti-NMDAR antibody levels, consistent with an immunomodulatory mechanism of action.

🥁🎉The Psychosis Collective proudly presents our first preprint

𝐂𝐥𝐨𝐳𝐚𝐩𝐢𝐧𝐞 𝐬𝐮𝐩𝐩𝐫𝐞𝐬𝐬𝐞𝐬 𝐚𝐮𝐭𝐨𝐢𝐦𝐦𝐮𝐧𝐢𝐭𝐲 𝐝𝐫𝐢𝐯𝐢𝐧𝐠 𝐩𝐬𝐲𝐜𝐡𝐨𝐬𝐢𝐬-𝐥𝐢𝐤𝐞 𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐮𝐫 𝐢𝐧 𝐦𝐢𝐜𝐞

𝘈 𝘥𝘪𝘴𝘤𝘰𝘷𝘦𝘳𝘺 𝘫𝘰𝘶𝘳𝘯𝘦𝘺 𝘪𝘯 𝘵𝘩𝘳𝘦𝘦 𝘢𝘤𝘵𝘴

starring Le He & Harriet Feldman

www.biorxiv.org/content/10.6...

We wanted to understand how antipsychotics work. Thread🧵

Well done @debdattomookherjee.bsky.social 👏

"Not all P-bodies are formed equally"

New from Debdatto Mookherjee, Madeleine Rommel and Anne Spang! 🥳

Very grateful to everyone who made this work possible. I feel incredibly lucky to have worked with such an amazing team.

Special thanks to: Jakob El Kholtei, KJ Jenie, @mcolomerr.bsky.social, and of course our wonderful collaborator Bogdan Bintu and my mentor @schierlab.bsky.social

Rewiring an olfactory circuit by altering cell-surface combinatorial code - Nature In Drosophila, changing the expression of a small set of cell-surface proteins in just one type of olfactory neuron rewires its connections almost entirely to a new postsynaptic partner neuron type, altering the fly’s odour response and courtship behaviour.

Nature research paper: Rewiring an olfactory circuit by altering cell-surface combinatorial code

go.nature.com/3MbCoZT

👏👏

The evolutionary origins of synaptic proteins and their changing roles in different organisms across evolution Nature Reviews Neuroscience - Recent studies have shed further light on the evolutionary origins of chemical synapses, In this Review, Colgren and Burkhardt explore how ancient proteins were...

First neurons didn’t appear overnight. We trace their roots to ancient secretory cells - showing how lifestyle & behavior shaped the evolution of first synapses.🧠🌊 #Evolution #Neuroscience

Our latest in @natrevneuro.nature.com
Link: rdcu.be/eMX3E

@jeffcolgren.bsky.social @msarscentre.bsky.social

Novel environment exposure drives temporally defined and region-specific chromatin accessibility and gene expression changes in the hippocampus - Nature Communications Hippocampal neurons adapt to experience through changes in gene expression and chromatin accessibility. Here, authors show that novel environment exposure induces region- and cell-type specific transc...

Extremely excited to share the outcome of a fantastic collaboration with @erinduffyphd.bsky.social revealing how experiences reshape hippocamapl chromatin and gene expression.
Check out our searchable gene database and look up your favorite gene 🧬

www.nature.com/articles/s41...

Choroid plexus sex differences in secretory signalling and immune compartments The choroid plexus (ChP)- cerebrospinal fluid (CSF) axis is emerging as a key regulator of the brain environment. The ChP is a multi-functional structure, which forms the blood-CSF barrier, and acts a...

New pre-print on sex differences in the choroid plexus- the 🧠's fluid secretion organ. Important differences in secretory signaling & immune compartments that can impact the 🧠 in health & disease. ‪@karol-kaiser.bsky.social‬@violesilvar.bsky.social‬ Luca von Allmen. 🧪
www.biorxiv.org/content/10.1...

Molecular programs specifying properties and plasticity of parvalbumin interneuron innervation Parvalbumin-positive (PV) interneurons, a class of fast-spiking GABAergic interneurons, govern gain-control and the timing of neuronal signal propagat…

@scheiffelelab.bsky.social and I discussed the unique properties of synapses onto parvalbumin interneurons, the current knowledge & future aspects of the molecular mechanisms regulating these synaptic inputs: www.sciencedirect.com/science/arti...

A dynamic gene regulatory code drives synaptic development of hippocampal granule cells www.biorxiv.org/content/10.1101/2025.03....

Cell atlas of the endometrium in women with PCOS may lead to better treatment Women with polycystic ovary syndrome (PCOS) find it harder to get pregnant, have more frequent miscarriages and have a higher risk of developing endometrial cancer. Now, in a new study published in Na...

A new study in @natmedicine.bsky.social by KI professor @elisabetsv.bsky.social and colleagues shows that the endometrium of women with #PCOS differs in terms of both the composition of individual cells and gene expression. The results open the door to new treatments 🧪 news.ki.se/cell-atlas-o...

Rewiring an olfactory circuit by altering the combinatorial code of cell-surface proteins Proper brain function requires the precise assembly of neural circuits during development. Despite the identification of many cell-surface proteins (CSPs) that help guide axons to their targets, it re...

In drosophila, by manipulating sets of surface proteins, you can re-engineer connectivity of olfactory neurons and generate a new neuron type that alters courtship behavior. Impressive work from the Luo lab.
doi.org/10.1101/2025...

Long-term in vivo imaging of single neurons in the developing mouse brain from early postnatal days on. A game-changer in figuring out developmental trajectories. From the Cossart lab.
doi.org/10.1101/2025...

Understanding the molecular diversity of synapses Nature Reviews Neuroscience - The set of proteins present at synapses determines their heterogeneous functions and properties. In this Review, van Oostrum and Schuman describe the molecular...

🎅 Excited to share our review in @natrevneurosci.bsky.social with @erin-schuman.bsky.social: “Understanding the Molecular Diversity of Synapses”🧠 Classification, importance of systems approaches, sources of diversity, and more! rdcu.be/d2xxF
@snsf-ch.bsky.social @maxplanck.de @biozentrum.bsky.social

Big day for single cell and neuroscience. Trio of single cell perspective pieces discussing applications, opportunities, challenges, and validation of single cell and spatial genomics in neuroscience are out now in Nature Neuroscience. Links in thread below.👇 1/n