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Posts by Gregory MS

Evaluation of the Effects of Laughter Yoga on Pain Intensity, Stress, and Beta-endorphin Levels in Patients With Multiple Sclerosis Clinical trial related to Multiple Sclerosis.

New clinical trial
Evaluation of the Effects of Laughter Yoga on Pain Intensity, Stress, and Beta-endorphin Levels in Patients With Multiple Sclerosis

#ClinicalTrials #MultipleSclerosis #MSchat #Neurology

2 hours ago 1 0 0 0
Comparison of Frailty, Physical Fitness Parameters, and Irisin Levels Between Patients With Multiple Sclerosis and Healthy Volunteers Clinical trial related to Multiple Sclerosis.

New clinical trial
Comparison of Frailty, Physical Fitness Parameters, and Irisin Levels Between Patients With Multiple Sclerosis and Healthy Volunteers

#ClinicalTrials #MultipleSclerosis #MSchat #Neurology

2 hours ago 0 0 0 0
An Open-Label Clinical Study to Evaluate the Safety and Pharmacodynamics of QH103 Cell Injection in the Treatment of Patients With Relapsed/Refractory Antibody-Mediated Neurological Autoimmune Diseases. Clinical trial related to Multiple Sclerosis.

New clinical trial
An Open-Label Clinical Study to Evaluate the Safety and Pharmacodynamics of QH103 Cell Injection in the Treatment of Patients With Relapsed/Refractory Antibody-Mediated Neurological Autoimmune Diseases.

#ClinicalTrials #MultipleSclerosis #MSchat #Neurology

2 hours ago 0 0 0 0
Influance of Walking Fatigability on Spatiotemporal Gait Parameters and Risk of Falling in Patients With Multiple Scalerosis Clinical trial related to Multiple Sclerosis.

New clinical trial
Influance of Walking Fatigability on Spatiotemporal Gait Parameters and Risk of Falling in Patients With Multiple Scalerosis

#ClinicalTrials #MultipleSclerosis #MSchat #Neurology

2 hours ago 1 0 0 0
A Clinical Study on the Safety and Tolerability of Universal STAR-T Cell Injection in Patients With Multiple Sclerosis. Clinical trial related to Multiple Sclerosis.

New clinical trial
A Clinical Study on the Safety and Tolerability of Universal STAR-T Cell Injection in Patients With Multiple Sclerosis.

#ClinicalTrials #MultipleSclerosis #MSchat #Neurology

2 hours ago 0 0 0 0
The Effect of an Exercise Intervention on Serum Glial Fibrillary Acidic Protein (GFAP), Brain Volumetry and and Functional Outcomes in Patients With Multiple Sclerosis: A Randomized Controlled Trial Clinical trial related to Multiple Sclerosis.

New clinical trial
The Effect of an Exercise Intervention on Serum Glial Fibrillary Acidic Protein (GFAP), Brain Volumetry and and Functional Outcomes in Patients With Multiple Sclerosis: A Randomized Controlled Trial

#ClinicalTrials #MultipleSclerosis #MSchat #Neurology

2 hours ago 0 0 0 0
Therapeutic Ultrasound for the Treatment of Demyelinating Diseases


#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky

23 hours ago 0 0 0 0
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ARID1B regulates sphingolipid metabolism and myelin development via STAG2: Mechanistic insights into ARID1B-related coffin–siris syndrome Coffin-Siris syndrome is predominantly attributed to variants in ARID1B gene. Three CSS patients with pathogenic ARid1B variants showed hypomyelination, motor delay and delayed myelination. The study

Coffin-Siris syndrome is predominantly attributed to variants in ARID1B gene. Three CSS patients with pathogenic ARid1B variants showed hypomyelination, motor delay and delayed myelination. The study reveals a novel ARID 1B-STAG2-sphingo...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky

23 hours ago 1 0 0 0
Cannabinoid CB1 receptors drive oligodendrocyte maturation during myelin regeneration


#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky

2 days ago 0 0 0 0
Resveratrol Attenuates Neuroinflammation and Myelination Deficits in Repeated Sevoflurane‐Exposed Neonatal Mice Sevoflurane, a widely used anaesthetic, impairs cognitive and fine motor functions in neonatal mice. Resveratrol of 30 mg/kg was administered intraperitoneally 1 h before each exposure. Myelinati

Sevoflurane, a widely used anaesthetic, impairs cognitive and fine motor functions in neonatal mice. Resveratrol of 30 mg/kg was administered intraperitoneally 1 h before each exposure. Myelination and neuroinflammatory response...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky

2 days ago 1 1 0 0
Muscone promotes remyelination and alleviates Parkinson’s disease by targeting FKBP5 in MPTP-induced mouse model There is a need for new treatments for Parkinson''s disease (PD). Promoting myelin renewal might be one promising avenue. The study aimed to evaluate the therapeutic efficacy of the natural co

There is a need for new treatments for Parkinson''s disease (PD). Promoting myelin renewal might be one promising avenue. The study aimed to evaluate the therapeutic efficacy of the natural compound muscone (Mus) on PD pathology ...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky

2 days ago 0 0 0 0
NIM5 series brain-penetrant NLRP3 inflammasome inhibitors suppress neuroinflammation in EAE and Alzheimer''s models Brain-penetrant NLRP3 inhibitor is needed for CNS-targeted therapeutic development. In vitro, systemic administration attenuated neuronal injury and improved behavioral outcomes in both EAE and Aβ-ind

Brain-penetrant NLRP3 inhibitor is needed for CNS-targeted therapeutic development. In vitro, systemic administration attenuated neuronal injury and improved behavioral outcomes in both EAE and Aβ-induced mouse models.
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky

2 days ago 0 0 0 0
Danish non-inferiority study of ocrelizumab and rituximab in MS: A randomized study comparing the efficacy of ocrelizumab and rituximab in active multiple sclerosis Clinical trial related to Multiple Sclerosis.

New clinical trial
Danish non-inferiority study of ocrelizumab and rituximab in MS: A randomized study comparing the efficacy of ocrelizumab
and rituximab in active multiple sclerosis

#ClinicalTrials #MultipleSclerosis #MSchat #Neurology

4 days ago 0 0 0 0
The HIt HArd and hiT Early in Multiple Sclerosis Trial - HiHat Trial A Phase 2 Study of Sequential Treatment With Rituximab and Cladribine for Relapsing-remitting Multiple Sclerosis Clinical trial related to Multiple Sclerosis.

New clinical trial
The HIt HArd and hiT Early in Multiple Sclerosis Trial - HiHat Trial A Phase 2 Study of Sequential Treatment With Rituximab and Cladribine for Relapsing-remitting Multiple Sclerosis

#ClinicalTrials #MultipleSclerosis #MSchat #Neurology

5 days ago 0 0 0 0
A randomized, Phase 3, open-label study to investigate pharmacokinetics, safety, and efficacy of subcutaneous compared to intravenous frexalimab in adult participants with multiple sclerosis. Clinical trial related to Multiple Sclerosis.

New clinical trial
A randomized, Phase 3, open-label study to investigate pharmacokinetics, safety, and efficacy of subcutaneous compared to intravenous frexalimab in adult participants with multiple sclerosis.

#ClinicalTrials #MultipleSclerosis #MSchat #Neurology

5 days ago 0 0 0 0
Home-based Assessment of Medication Understanding and Use in People With Multiple Sclerosis Clinical trial related to Multiple Sclerosis.

New clinical trial
Home-based Assessment of Medication Understanding and Use in People With Multiple Sclerosis

#ClinicalTrials #MultipleSclerosis #MSchat #Neurology

5 days ago 0 0 0 0
Immune-evasive stem cells: engineering tolerance and reprogramming microenvironments for regenerative therapy Stem cell transplantation holds significant promise for regenerative medicine, but immune rejection remains a major obstacle. Recent advances leverage CRISPR/Cas9 to engineer hypoimmunogenic indu

Stem cell transplantation holds significant promise for regenerative medicine, but immune rejection remains a major obstacle. Recent advances leverage CRISPR/Cas9 to engineer hypoimmunogenic induced pluripotent stem cells. Future re...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky

6 days ago 1 0 0 0
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Efficacy of Extracorporeal Shock Wave Therapy in Enhancing Plantar Sensitivity and Postural Stability in Multiple Sclerosis: A Quantitative Gait and Sensory Analysis Clinical trial related to Multiple Sclerosis.

New clinical trial
Efficacy of Extracorporeal Shock Wave Therapy in Enhancing Plantar Sensitivity and Postural Stability in Multiple Sclerosis: A Quantitative Gait and Sensory Analysis

#ClinicalTrials #MultipleSclerosis #MSchat #Neurology

6 days ago 0 0 0 0
Prospective Cohort Study of Clinical and Biological Data in Patients With Autoimmune Diseases (Immun4Cure Cohort) Clinical trial related to Multiple Sclerosis.

New clinical trial
Prospective Cohort Study of Clinical and Biological Data in Patients With Autoimmune Diseases (Immun4Cure Cohort)

#ClinicalTrials #MultipleSclerosis #MSchat #Neurology

6 days ago 0 0 0 0
The Swedish BioFINDER 2 Study Clinical trial related to Multiple Sclerosis.

New clinical trial
The Swedish BioFINDER 2 Study

#ClinicalTrials #MultipleSclerosis #MSchat #Neurology

1 week ago 0 0 0 0
<scp>RXR</scp> Gamma Enables Oligodendrocyte Differentiation by Suppressing Sonic Hedgehog Signaling RXRg is involved in the induction of the thyroid hormone-driven differentiation process and in refining it toward an oligodendrogenic cell fate. An inhibition of SHH signaling by cyclopamine or GANT61

RXRg is involved in the induction of the thyroid hormone-driven differentiation process and in refining it toward an oligodendrogenic cell fate. An inhibition of SHH signaling by cyclopamine or GANT61 normalized the differentiation defic...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky

1 week ago 1 0 0 0
Efficient Induction of Oligodendrocyte Lineage From Pluripotent Stem Cells via Temporal Modulation of <scp>OLIG2</scp> ( <scp>S147A</scp> ) and <scp>SOX10</scp> There are several protocols for generating oligodendrocytes (OLs) from human pluripotent stem cells, but they are limited by long culture duration, intensive handling and low yield of mature OLs. We d

There are several protocols for generating oligodendrocytes (OLs) from human pluripotent stem cells, but they are limited by long culture duration, intensive handling and low yield of mature OLs. We developed a Tetucible system to contro...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky

1 week ago 0 0 0 0
Assessing Metabolic Changes in Multiple Sclerosis Using Hyper-polarized Carbon 13 MRI Clinical trial related to Multiple Sclerosis.

New clinical trial
Assessing Metabolic Changes in Multiple Sclerosis Using Hyper-polarized Carbon 13 MRI

#ClinicalTrials #MultipleSclerosis #MSchat #Neurology

1 week ago 2 1 0 0
Ultra-High Resolution PET of the Human Brain and Spinal Cord in Healthy Aging, Dementia, Movement Disorders, ALS and Psychotic Disorders Clinical trial related to Multiple Sclerosis.

New clinical trial
Ultra-High Resolution PET of the Human Brain and Spinal Cord in Healthy Aging, Dementia, Movement Disorders, ALS and Psychotic Disorders

#ClinicalTrials #MultipleSclerosis #MSchat #Neurology

1 week ago 1 0 0 0
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Evaluating the Feasibility and Effectiveness of an Online Psychological Intervention Targeting Problem-Solving and Coping Strategies in People With Multiple Sclerosis Clinical trial related to Multiple Sclerosis.

New clinical trial
Evaluating the Feasibility and Effectiveness of an Online Psychological Intervention Targeting Problem-Solving and Coping Strategies in People With Multiple Sclerosis

#ClinicalTrials #MultipleSclerosis #MSchat #Neurology

1 week ago 0 0 0 0
An Exploratory Clinical Study Evaluate the Safety and Efficacy of Universal Universal Allogeneic CAR-T Cells Targeting CD19 and BCMA in the Treatment of B Cell-Related Autoimmune Disease Clinical trial related to Multiple Sclerosis.

New clinical trial
An Exploratory Clinical Study Evaluate the Safety and Efficacy of Universal Universal Allogeneic CAR-T Cells Targeting CD19 and BCMA in the Treatment of B Cell-Related Autoimmune Disease

#ClinicalTrials #MultipleSclerosis #MSchat #Neurology

1 week ago 0 0 0 0
The Effect of Internal- or External-Focused Exercise Training, Administered in Conjunction With a Cognitive Task, on Walking, Balance, and Cognitive Functions in Individuals With Multiple Sclerosis Clinical trial related to Multiple Sclerosis.

New clinical trial
The Effect of Internal- or External-Focused Exercise Training, Administered in Conjunction With a Cognitive Task, on Walking, Balance, and Cognitive Functions in Individuals With Multiple Sclerosis

#ClinicalTrials #MultipleSclerosis #MSchat #Neurology

1 week ago 0 0 0 0
Turkish Version of the Neurogenic Bladder Symptom Score Short Form: Cross-Cultural Adaptation and Validation-Reliability Study Clinical trial related to Multiple Sclerosis.

New clinical trial
Turkish Version of the Neurogenic Bladder Symptom Score Short Form: Cross-Cultural Adaptation and Validation-Reliability Study

#ClinicalTrials #MultipleSclerosis #MSchat #Neurology

1 week ago 0 0 0 0
A Study Investigating Drivers of Physician and Patient Satisfaction Towards Treatment Clinical trial related to Multiple Sclerosis.

New clinical trial
A Study Investigating Drivers of Physician and Patient Satisfaction Towards Treatment

#ClinicalTrials #MultipleSclerosis #MSchat #Neurology

1 week ago 0 0 0 0
Measurement Properties of the Walking Adaptability Ladder Test and Foot Tap Test in People With Multiple Sclerosis With Mild Disability Clinical trial related to Multiple Sclerosis.

New clinical trial
Measurement Properties of the Walking Adaptability Ladder Test and Foot Tap Test in People With Multiple Sclerosis With Mild Disability

#ClinicalTrials #MultipleSclerosis #MSchat #Neurology

1 week ago 1 0 0 0