5-HT1B receptor agonists promote Schwann cell myelination Zolmitriptan is a 5-HT1B/1D receptor agonist that promotes myelination and ameliorates motor dysfunction in Tr-Ncnp mice.

Zolmitriptan is a 5-HT1B/1D receptor agonist that promotes myelination and ameliorates motor dysfunction in Tr-Ncnp mice.
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Saikosaponin B2 improves depressive behavior of VaD mice by promoting oligodendrocyte maturation via regulating Akt/mTOR pathway SSB2 significantly ameliorated BCAS/CRS-induced depression-like behavior and myelin structure damage in the corpus callosum of mice. SSB2 increased the number of CC1~+ cells and the expression of

SSB2 significantly ameliorated BCAS/CRS-induced depression-like behavior and myelin structure damage in the corpus callosum of mice. SSB2 increased the number of CC1~+ cells and the expression of myelin-related proteins.
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LPX-TI641, a Tim3/4 Agonist, Induces Long-Term Immune Tolerance in Multiple Sclerosis Models LPX-TI641 is an orally bioavailable, clinical-stage small-molecule agonist of Tim-3/4. It promotes antigen-independent immune tolerance through Tim receptor agonism and Treg expansion. In EAE mod

LPX-TI641 is an orally bioavailable, clinical-stage small-molecule agonist of Tim-3/4. It promotes antigen-independent immune tolerance through Tim receptor agonism and Treg expansion. In EAE models, treatment significantly reduced ...
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Oxymatrine regulates microglia to produce IFN-β by activating the STING/TBK1/IRF3 pathway against experimental autoimmune encephalomyelitis Oxyxymatrine is an alkaloid with the property of immunomodulation. It inhibits experimental autoimmune encephalomyelitis (EAE) by promoting the production of interferon-β (IFN-β). It also reduces micr

Oxyxymatrine is an alkaloid with the property of immunomodulation. It inhibits experimental autoimmune encephalomyelitis (EAE) by promoting the production of interferon-β (IFN-β). It also reduces microglia/macrophage infiltration ...
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Poliumoside Alleviates Neuroinflammation and Oxidative Stress After Spinal Cord Injury by Activating the PI3K/AKT/mTOR Signaling Pathway Poliumoside (POL) is an anti-inflammatory, antioxidant, and neuroprotective molecule. Spinal cord injury (SCI) is a debilitating neurological disorder. Systemic drug toxicity for two POL dosages (15 m

Poliumoside (POL) is an anti-inflammatory, antioxidant, and neuroprotective molecule. Spinal cord injury (SCI) is a debilitating neurological disorder. Systemic drug toxicity for two POL dosages (15 mg/kg, 30 mg/ kg) was evalua...
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Dimethyl fumarate protects from experimental autoimmune encephalomyelitis by modulating colonic immune cells Dimethyl fumarate (DMF) is an oral therapy approved for the treatment of relapsing-remitting multiple sclerosis. It is also known to reduce disease severity in experimental autoimmune encephalomyeliti

Dimethyl fumarate (DMF) is an oral therapy approved for the treatment of relapsing-remitting multiple sclerosis. It is also known to reduce disease severity in experimental autoimmune encephalomyelitis (EAE). Female C57BL/6J mice we...
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Proanthocyanidin B2 Alleviates Cuprizone-Induced Demyelination by Regulating the Astrocytic xCT/GSH/GPX4 Axis PCB2 has been shown to alleviate demyelination in the cuprizone (CPZ) mouse model. It attenuates neuroinflammation and oxidative stress in both the cerebral microenvironment and astrocytes (AS). The x

PCB2 has been shown to alleviate demyelination in the cuprizone (CPZ) mouse model. It attenuates neuroinflammation and oxidative stress in both the cerebral microenvironment and astrocytes (AS). The xCT/GSH/GPX4 axis is a key r...
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Transcriptional dynamics of the oligodendrocyte lineage and its regulation by the brain erythropoietin system Erythropoietin (EPO) stimulates all oligodendroglial lineage cells directly, driving differentiation/maturation. Mice lacking EPOR from mature oligododendrocytes show subtle deficiencies of adult

Erythropoietin (EPO) stimulates all oligodendroglial lineage cells directly, driving differentiation/maturation. Mice lacking EPOR from mature oligododendrocytes show subtle deficiencies of adult myelination in hippocampus and mild ...
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oops, there is an unexpected &#𝐱𝟐𝐅; :-)

Original post on sakurajima.moe

Example:


{:#bold:}{:TITLE:}{:/bold:}
{:#italic:}{:TITLE:}{:/italic:}
{:#gothic:}{:TITLE:}{:/gothic:}
{:#zalgo:}{:TITLE:}{:/zalgo:}

{:LINKTYPE:}: {:MEDIALINK:}
Songlink/Odesli: {:SONGLINK:}


𝐃𝐞𝐯𝐢𝐥 𝐀𝐍𝐓𝐇𝐄𝐌.&#𝐱𝟐𝐅;「𝐋𝐎𝐕𝐄〜極〜」
𝐷𝑒𝑣𝑖𝑙 𝐴𝑁𝑇𝐻𝐸𝑀.&#𝑥2𝐹;「𝐿𝑂𝑉𝐸〜極〜」
𝔇𝔢𝔳𝔦𝔩 𝔄𝔑𝔗𝔋𝔈𝔐.&#𝔵2𝔉 […]

2-Methoxyestradiol Treatment Prevents Graft-versus-Host Disease While Preserving Graft-versus-Leukemia Effect in Mice 2-Methoxyestradiol (2ME2, Panzem) is well-tolerated in phase I/II clinical trials for variety of tumors. Plasma levels of 2ME2 may increase up to 1,000-fold during pregnancy. It can also reduce t

2-Methoxyestradiol (2ME2, Panzem) is well-tolerated in phase I/II clinical trials for variety of tumors. Plasma levels of 2ME2 may increase up to 1,000-fold during pregnancy. It can also reduce the mortality and morbidity associated...
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GH16 Glycoside Hydrolases Divergently Contribute to Fungal Development, Stress Tolerance, and Virulence of an Insect Fungal Pathogen 13 members of the GH16 family were systemically and genetically characterized in the EPF Beauveria bassiana. They are involved in cell wall metabolism and chitin assembly/metabolism.

13 members of the GH16 family were systemically and genetically characterized in the EPF Beauveria bassiana. They are involved in cell wall metabolism and chitin assembly/metabolism.
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Blocking CXCR4+ CD4+ T cells reprograms Treg-mediated immunosuppression via modulating the Rho-GTPase/NF-κB signaling axis CXCR4 is a regulator of exhausted CD8+ T cell phenotypes in cancer. It regulates the Rho-GTPase/NF-κB signaling axis and suppresses Treg cell-mediated immunosuppression within tumors.

CXCR4 is a regulator of exhausted CD8+ T cell phenotypes in cancer. It regulates the Rho-GTPase/NF-κB signaling axis and suppresses Treg cell-mediated immunosuppression within tumors.
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Nutraceutical Supplementation Effects on Subjective Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Systematic Review Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition marked by severe, long-lasting fatigue and exhaustion that does not improve with rest. Nutritional sup

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition marked by severe, long-lasting fatigue and exhaustion that does not improve with rest. Nutritional supplements and dietary interventions ar...
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Therapeutics Potential of Cronassial in Experimental Autoimmune Encephalomyelitis: Insights Into Glycosphingolipids and Humoral Immunity There is an increased concentration of proinflammatory cytokines in plasma, homogenates of the brain and spinal cord, serum circulating immune complexes, APO-1/Fas, and glycosphingolipids during

There is an increased concentration of proinflammatory cytokines in plasma, homogenates of the brain and spinal cord, serum circulating immune complexes, APO-1/Fas, and glycosphingolipids during experimental autoimmune encephalomyel...
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Reactive nitrogen species as therapeutic targets for autophagy/mitophagy modulation to relieve neurodegeneration in multiple sclerosis: Potential application for drug discovery Multiple sclerosis is a neuroinflammatory disease with limited therapeutic effects. Active autophagy/mitophagy could mediate neurodegeneration. Reactive nitrogen species (RNS) serve as key regula

Multiple sclerosis is a neuroinflammatory disease with limited therapeutic effects. Active autophagy/mitophagy could mediate neurodegeneration. Reactive nitrogen species (RNS) serve as key regulators for redox-related modific...

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Incidence and prevalence of multiple sclerosis in China and other Asian countries The prevalence of MS in Asian countries is thought to be lower than in Western countries. Prevalence rates in China range between 0.88 cases/100,000 population in 1986 and 5.2 cases in 2013. The

The prevalence of MS in Asian countries is thought to be lower than in Western countries. Prevalence rates in China range between 0.88 cases/100,000 population in 1986 and 5.2 cases in 2013. The increase observed in Japan was...

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