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Posts by Sam Woodburn

New preprint from collaboration with @sn-lab.bsky.social - 2p imaging of psilocybin's effects on neurovascular coupling 🧠🔬

We found that psilocybin prolongs the neurovascular response, independent of neural activity.

This would affect how we should interpret fMRI BOLD studies of psychedelics ‼️

8 months ago 38 12 3 1
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Protect the integrity of the US National Institutes of Health Letter to the Editor

These members of the NIH Council of Councils are voicing serious concerns about NIH grant terminations, restructure, and budget cuts

go.nature.com/46Vr8t2

8 months ago 66 36 1 7

Thanks for walking me through it - your work is super cool!!

9 months ago 1 0 0 0

Likewise!

9 months ago 1 0 0 0
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#GRCPsychedelics - What a blast! It was great to talk science with so many incredible people in the field. Can't wait to do it all over again!

9 months ago 19 5 2 0
SIPLab

Please repost! We're hiring a postdoc to work with me and
@salagapan.bsky.social on an exciting interdisciplinary project in human neuroscience and brain-body interactions underlying effortful behavior in health and mood disorders.

siplab.gatech.edu/postdoc_ad_2...

9 months ago 27 30 1 3
Vought's comments set off Hill furor as shutdown threat
looms

Vought's comments set off Hill furor as shutdown threat looms

Earlier today we said everyone should oppose the current rescission package, even though it does not include #NIH provisions.

We said this bill will embolden Trump and Vought to enact massive NIH budget cuts via another rescission.

Now Vought confirms. 1/

9 months ago 72 23 4 1
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Exclusive: NIH to dismiss dozens of grant reviewers to align with Trump priorities The move would undo years of work, leaving advisory councils understaffed, and without the full expertise needed for reviews.

NEW: In an unprecedented move, the NIH will soon disinvite dozens of scientists about to take positions on advisory councils that make final decisions on grant funding.

NIH staff were told to select others aligned with the Trump administration and told to expect placements by political appointees.

9 months ago 1037 786 46 178
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NIH and FDA hosted a workshop on July 7 on efforts to reduce the use of animal models in research, NIH has formally announced a policy change. The agencies have invited comments through the workshop’s webpage. PLEASE COMMENT. The portal will be open until 5pm ET on Monday, July 14 (TODAY).

9 months ago 13 15 1 0
Nature: US senators poised to reject Trump’s proposed massive science cuts

Committee gives first hint that policymakers might preserve, rather than slash, funding for US National Science Foundation and other agencies.

Nature: US senators poised to reject Trump’s proposed massive science cuts Committee gives first hint that policymakers might preserve, rather than slash, funding for US National Science Foundation and other agencies.

DO NOT GIVE UP!

Our advocacy is working.

A key Senate committee has indicated that it will reject Trump’s proposed cuts to science agencies including NASA and the NSF.

Keep speaking up and calling your electeds 🗣️🗣️🗣️

9 months ago 1338 440 8 23
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Sign The Open Letter to Stand Up For Science Now! Science is under siege. Trump’s latest Executive Order calls for politically appointed science commissars to evaluate research. Join us in adding your name to our open letter condemning Trump’s escala...

This isn’t just a warning — it’s a call to action.

🛑 Stand against a future where facts are filtered by Trump’s ideology. Sign & share our open letter. ⬇️

actionnetwork.org/petitions/op...

10 months ago 48 23 0 0
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Microglial brain-derived neurotrophic factor (BDNF) supports the behavioral and synaptogenic effects of ketamine Microglia have been implicated in the pathogenesis for several psychiatric disorders, yet comparatively little is known about their role in treatments for these conditions. Prior work showed that the ...

Microglia are often framed as driving maladaptive behavior in stress and depression, but what if they're important for treatment as well?

In the final project from my graduate studies, we explored whether microglial BDNF supports the effects of low-dose ketamine.

www.biorxiv.org/content/10.1...

11 months ago 5 2 0 0

If you read one thing today, make it this:

11 months ago 32 10 0 0
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PhD Timeline xkcd.com/3081

11 months ago 60066 20550 590 831

I am a professor at Columbia University. All of the student NIH training grants have been canceled and now there are reports that ALL funding will be frozen. Why are Universities not banding together and speaking out publicly and forcibly about governmental attacks on biomedical research?

1 year ago 1309 407 52 19
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IF YOU FIGHT, THEY BACK DOWN.

The only explanations for institutional compliance are you're cowards or you like it.

1 year ago 24 9 0 0
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NIH freezes all research grants to Columbia University Amid negotiations with Trump, the university could risk losing nearly $700 million

Exclusive: Weeks after President Donald Trump’s administration ordered NIH to pull $250 million in biomedical research grants to Columbia University, the agency is freezing all remaining grant money owed to the university until further notice. scim.ag/4if5Rg1

1 year ago 728 468 82 287
Effect of 2 mg/kg psilocybin on fear extinction in mice.

Effect of 2 mg/kg psilocybin on fear extinction in mice.

@samcwoodburn.bsky.social previously tested 2 mg/kg psilocybiin, among many other conditions, for fear extinction.
pubs.acs.org/doi/full/10....

The results are very close... Ours in the top, the cross-lab average in the bottom

1 year ago 11 3 1 0
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The NIH firing plan is really a radical institute merger and an authoritarian takeover this is an Orbanization of US science: a move to exert political control over discovery, which will kill the US medical research industry and end cancer cures. The plan must be stopped. We can act.

"The consolidation/RIF plan pulls power away from scientists and puts it in the hands of political employees. It sets up Trump and Musk to kill NIH as an evidence-based science funder. We must stop this plan."

New contributed post on our blog: Please read.
It describes Orban and authoritarianism. 🧪

1 year ago 230 107 6 8
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Graduate Reductions Across Biomedical Sciences (2025)

🚨 Over 70 graduate programs in the biological and biomedical sciences have frozen or slashed admissions.

The consequences are profound—how many brilliant minds are being shut out of research entirely? How much future discovery is being lost before it even begins?

docs.google.com/spreadsheets...

1 year ago 552 276 34 18
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Don’t wait out four hard years: speak truth to power The importance of diversity in science is an unshakeable reality that the scientific community must stand by.

“Yet, far from acting in courageous defiance, many scientists and administrators now seem to think that the best response to the war on DEI is to keep their heads low and wait out four hard years.”

Hell yes, Art Caplan. More courageous defiance, less quiet cowardice.
www.nature.com/articles/d41...

1 year ago 308 83 6 2

Justin is a phenomenal scientist and all around great person! After working together for 5 years, I seriously can't recommend him enough if you're looking for someone to tackle difficult research questions

1 year ago 1 0 0 0
A thank you card and magnet from my student after their trip abroad.

A thank you card and magnet from my student after their trip abroad.

I feel fortunate to mentor such thoughtful students! I'm not sure if they're aware, but stuff like this makes my whole week.

It feels good to know I can have a similar impact on them as my mentors have had on me.

1 year ago 1 0 0 0
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Classification of psychedelics and psychoactive drugs based on brain-wide imaging of cellular c-Fos expression - Nature Communications A challenge in psychiatric drug discovery is to predict the therapeutic potential of a novel compound. Here, the authors show that brain-wide imaging of immediate early gene expression can be used to ...

Can whole-brain imaging of cellular c-Fos signals be used to classify #psychedelics? 🧠🔬💊

Our study by @aboharbf.bsky.social and @pashadavoudian.bsky.social, developing an imaging and machine learning pipeline to test a panel of psychoactive drugs.

Paper here 👇
www.nature.com/articles/s41...

1 year ago 123 44 5 4
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Trump signs sweeping order to further restrict trans care for minors nationwide The order says the U.S. will not “fund, sponsor, promote, assist, or support” transition-related care for minors, which it defines as those under age 19.

The current administration is doing everything it can to irreparably harm trans people and destroy their dignity and well-being.

Yet this is getting way less discussion and conversation than threats to grants.

www.nbcnews.com/nbc-out/out-...

1 year ago 17 10 1 1
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Join researchers across the country in fighting restrictions on the NIH Please click the link to complete this form.

Academic workers across the country are organizing to call on our congressional representatives on Thursday, 1/30, at 3pm ET / 12pm PT to demand these restrictions be lifted immediately.
There will be a training over zoom at the beginning of the event.
Join us!
form.jotform.com/250226137228...

1 year ago 521 405 16 26

Working w/ a reporter on the consequences of the NIH/NSF freezes (e.g., training pipelines, how grants support clinical time for trials)

If you've had a grant impacted, some organizational perspective (e.g., in APPIC leadership/DCT role) + are willing to share your experience please shoot me a DM

1 year ago 79 34 1 0

What a great panel of basic and translational research! Also, big thank you to @mayoonthebrain.bsky.social for not hitting us with her unconditioned stimulus in the morning 🙏

1 year ago 11 2 0 0

I need coffee shops to realize that deciding to be vegan ≠ deciding that $11 is a good piece for toast

1 year ago 0 0 0 0
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Scenes like this are my favorite thing about being on East Coast time #winterbrain #wcbr2025

1 year ago 10 0 0 0