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Posts by Marija Backovic

Pour celles et ceux que ça intéressent, il existe une association "Mothers in Science" qui milite en faveur de l'égalité et de l'inclusion et propose de nombreuses actions afin d'améliorer les perspectives de carrière des femmes scientifiques avec des enfants

www.mothersinscience.com

1 week ago 27 25 0 1

This is why I’m not allowed in the wet lab anymore 🥼 🕺. My technique is too effective! 🤪

#PILife #TeamTomo 🧪

1 week ago 65 7 0 1
A full disc image of Earth, as seen from the Orion Crew Module. The planet is a pale blue, swirling with white clouds and glowing slightly lighter blue in place from reflected light. At lower left, a large brown landmass is Africa, with Spain and Portugal with twinkling lights where the planet curves. At top right, auroras glow in a thin green glow, just barely separated from the planet's surface. Earth is set against the black of space (pic: NASA/R.Wiseman)

A full disc image of Earth, as seen from the Orion Crew Module. The planet is a pale blue, swirling with white clouds and glowing slightly lighter blue in place from reflected light. At lower left, a large brown landmass is Africa, with Spain and Portugal with twinkling lights where the planet curves. At top right, auroras glow in a thin green glow, just barely separated from the planet's surface. Earth is set against the black of space (pic: NASA/R.Wiseman)

More context on this #Artemis II image:

* This is the night side, lit by moonlight. You can see city lights in Spain & Portugal, & a sliver of day at lower right

* The Sun is entirely behind Earth, which makes it a kind of solar eclipse, but w/ Earth doing the eclipsing instead of the Moon:
☀️🌍🚀🌕

2 weeks ago 13119 3712 234 321

Exposure to different viruses linked to Alzheimer's and vaccines prevent this, more and more proof accumulates over time (reviewers in higher impact journals: "but what's the mechanism?")

2 weeks ago 20 4 1 0
IMPACT OF PARENTHOOD ON UNIVERSITY EMPLOYMENT. Line graph shows how the probability of holding a research position changes from four years before to seven years after having children.

IMPACT OF PARENTHOOD ON UNIVERSITY EMPLOYMENT. Line graph shows how the probability of holding a research position changes from four years before to seven years after having children.

Becoming a parent is much more detrimental to women’s academic careers than it is to men’s

Read the full story: go.nature.com/4v4rxmQ

3 weeks ago 248 156 6 39
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Opinion | It’s Cruel to Take Away People’s H.I.V. Medication States are rolling back coverage for lifesaving medications.

In @nytopinion.nytimes.com

“Not many problems can be solved by simply taking a daily pill,” Maia Szalavitz writes in a guest essay. “HIV infection is one of them, and we can’t afford to go back to the time when it wasn’t.”

1 month ago 104 22 4 5
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Hard life according to my cat.

1 month ago 17 3 0 1
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AlphaFold database has entered the era of complexes. Together with NVIDIA, DeepMind and EBI, we use ColabFold, OpenFold and MMseqs2-GPU to predict ~31 million complexes (homo & hetro-dimers) resulting in 1.8 million high-quality predictions
📄 research.nvidia.com/labs/dbr/ass...
🌐 alphafold.ebi.ac.uk

1 month ago 265 111 8 3
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Transposable elements in the dark genome - Nature Biotechnology Transposable elements (TEs), such as retrotransposons and endogenous retroviruses, are increasingly recognized for their important roles in genome function and impact on disease development. Residing ...

Transposable elements, such as retrotransposons and endogenous retroviruses, are being recognized for their important roles in genome function and impact on disease development. How can we translate our growing understanding of the 'dark genome' into therapeutics? go.nature.com/4tQ1zTn
rdcu.be/e7D2N

1 month ago 12 4 0 1

"Russian flu," the pandemic that hit in 1977, bears an evolutionary signature of having emerged from a lab, perhaps as part of a failed vaccine effort. Covid, mpox, Ebola, and other influenza pandemics don't. Here's my story on a new way to trace the origins of pandemics. Gift link: nyti.ms/46N0W33

1 month ago 246 85 3 6
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🔬✊ One year later, we #StandUpForScience again.

Attacks multiply. Funding shrinks. But our determination doesn't.

Science isn't opinion, it's the foundation of democracy.

Institut Pasteur researchers are mobilizing. Join us.

#StandUpForScience2026 #ScienceMatters #ResearchMatters

1 month ago 58 30 0 0

This is why we need to study persistent infections beyond the primary diseases they cause.
www.sciencedirect.com/science/arti...

1 month ago 2 0 0 0
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I aspire to exude as much confidence as this little Kinesin protein strutting along a microtubule while hauling intracellular cargo.

Look at that little guy go! 🔬🧪

1 month ago 3395 659 126 56
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L'autisme L’autisme est-il une maladie ? Une condition génétique ? Naît-on autiste ou le devient-on ? Pour mieux comprendre ce que la science sait de cette condition, qui touche environ 1 % de la population, Ch...

🎙️R2D2-MH coordinator @thomasbourgeron.bsky.social and #cocreation member Stéf Bonnot-Briey participated in a radio broadcast on #Autism, discussing #cocreation, science, lived experience and #inclusion.

🎧 Recommended for French speakers: www.radiofrance.fr/franceinter/...

#HorizonEU #Resilience

1 month ago 3 1 0 0

[Resources]

#AlphaFold protein and PPI prediction databases

1️⃣ Predictomes (genome maintenance & H2A/H2b) predictomes.org

2️⃣ Flypredictome www.flyrnai.org/tools/fly_pr...

3️⃣ Human interactome prodata.swmed.edu/humanPPI

4️⃣ BFVD (viral proteins) bfvd.steineggerlab.workers.dev

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8 months ago 43 14 1 1

Science is not truth.
Science is finding the truth.

When science changes its opinion, it didn't lie to you. It learned more.

2 months ago 4393 1401 55 18
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Could targeting viruses be a new hope against neurodegenerative diseases? Current therapies for neurodegenerative diseases largely manage symptoms and only modestly slow progression. This Perspective highlights emerging evidence that vaccines and antivirals may lower…

Despite decades of intensive research, current approaches to treating #NeurodegenerativeDiseases only slow down the seemingly inevitable. Could recent data associating #vaccines with reduced risk of #dementia offer an unexpected beacon of hope?🧪 @sparrerlab.bsky.social

2 months ago 25 10 0 0
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A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?

Excited to share our latest work in @science.org on a new small polymerase.
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2 months ago 500 210 10 28

No, DeepMind has not solved the protein folding problem.

#Alphafold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination.

2 months ago 93 24 2 0

Integrated structural biology at its best with fantastic talks in cryo-EM, NMR, and X-ray techniques
Also integration with other Instruct Centres, in this case Kay Grünewald Instruct-DE @cssbhamburg.bsky.social 'Conformational flexibility and molecular plasticity in herpesvirus entry and egress'

2 months ago 8 5 0 0
Vibrant color portrait of Jane S. Richardson, the visionary biophysicist and artist who revolutionized structural biology with her invention of ribbon diagrams. She gazes warmly at the camera with a bright, knowing smile that radiates quiet brilliance and decades of curiosity. Her silver-blonde hair woven with gentle waves. Large, elegant dangling earrings catch the light, and she wears a richly patterned brown blouse embroidered with intricate turquoise paisley motifs and delicate beadwork that echoes the molecular elegance she has spent her life depicting. Behind her floats a luminous, dreamlike backdrop of glowing molecular structures--interlocking hexagonal and ribbon-like forms in electric blues, teals, and greens--blending science and art in a single, living canvas.

Vibrant color portrait of Jane S. Richardson, the visionary biophysicist and artist who revolutionized structural biology with her invention of ribbon diagrams. She gazes warmly at the camera with a bright, knowing smile that radiates quiet brilliance and decades of curiosity. Her silver-blonde hair woven with gentle waves. Large, elegant dangling earrings catch the light, and she wears a richly patterned brown blouse embroidered with intricate turquoise paisley motifs and delicate beadwork that echoes the molecular elegance she has spent her life depicting. Behind her floats a luminous, dreamlike backdrop of glowing molecular structures--interlocking hexagonal and ribbon-like forms in electric blues, teals, and greens--blending science and art in a single, living canvas.

Hand-drawn and hand-colored (by Jane Richardson) scientific artwork known as a Richardson ribbon diagram (or “ribbon model”), one of the iconic visual inventions of Jane Richardson that transformed the way we see and understand protein structures. A graceful, three-dimensional tangle of protein backbone ribbons twists and spirals through space, rendered in soft pencil lines and luminous watercolor hues. Smooth golden-brown coils represent α-helices that curl like elegant ribbons, while broad teal-green arrows trace the flat, pleated strands of β-sheets slicing through the molecule with directional purpose. Thin, looping golden threads connect the secondary structures, creating a delicate, almost dance-like choreography of biology’s hidden architecture. The entire form is framed by a simple olive-green mat and dark border, giving the drawing the quiet dignity of both fine art and precise scientific illustration—a timeless bridge between molecular reality and human imagination.

Hand-drawn and hand-colored (by Jane Richardson) scientific artwork known as a Richardson ribbon diagram (or “ribbon model”), one of the iconic visual inventions of Jane Richardson that transformed the way we see and understand protein structures. A graceful, three-dimensional tangle of protein backbone ribbons twists and spirals through space, rendered in soft pencil lines and luminous watercolor hues. Smooth golden-brown coils represent α-helices that curl like elegant ribbons, while broad teal-green arrows trace the flat, pleated strands of β-sheets slicing through the molecule with directional purpose. Thin, looping golden threads connect the secondary structures, creating a delicate, almost dance-like choreography of biology’s hidden architecture. The entire form is framed by a simple olive-green mat and dark border, giving the drawing the quiet dignity of both fine art and precise scientific illustration—a timeless bridge between molecular reality and human imagination.

Jane Richardson was born #OTD in 1941

+ Developed the Richardson (ribbon) diagram to represent proteins' 3D structure (becoming a standard representation for protein structures)
+ MacArthur Fellow, 1985
+ Elected, Nat'l Academy of Sciences, 1991
+ President, Biophysical Society, 2012

#WomenInSTEM

2 months ago 268 93 3 7
Color photograph of Joan Steitz (Joan Argetsinger Steitz), the distinguished American molecular biologist and biochemist renowned for her groundbreaking discoveries in RNA biology, including the identification of small nuclear ribonucleoproteins (snRNPs) essential to RNA splicing. She is pictured in a close-up portrait within a laboratory or research setting, smiling warmly and directly at the camera with an engaging, approachable expression that conveys enthusiasm and expertise. Steitz has gray hair pulled back, striking blue eyes, and is wearing large, elaborate dangling earrings adorned with purple gemstones and metallic accents. She is dressed in a rich purple blouse. The softly blurred background includes scientific elements such as lab benches, equipment, monitors, charts, and partial signage, evoking the environment of her long career at Yale University where she served as Sterling Professor of Molecular Biophysics and Biochemistry. #JoanSteitz #MolecularBiology #WomenInScience #Biochemistry #RNA

Color photograph of Joan Steitz (Joan Argetsinger Steitz), the distinguished American molecular biologist and biochemist renowned for her groundbreaking discoveries in RNA biology, including the identification of small nuclear ribonucleoproteins (snRNPs) essential to RNA splicing. She is pictured in a close-up portrait within a laboratory or research setting, smiling warmly and directly at the camera with an engaging, approachable expression that conveys enthusiasm and expertise. Steitz has gray hair pulled back, striking blue eyes, and is wearing large, elaborate dangling earrings adorned with purple gemstones and metallic accents. She is dressed in a rich purple blouse. The softly blurred background includes scientific elements such as lab benches, equipment, monitors, charts, and partial signage, evoking the environment of her long career at Yale University where she served as Sterling Professor of Molecular Biophysics and Biochemistry. #JoanSteitz #MolecularBiology #WomenInScience #Biochemistry #RNA

Biochemist/molecular biologist Joan Steitz was born #OTD in 1941.

She (& team) figured out how our cells read/use genetic instructions to make proteins. A key person who helped crack the code on RNA—the molecule that acts like a messenger between DNA & and the proteins our bodies need. #WomenInSTEM

2 months ago 741 172 6 8
BindCraft: one-shot design of functional protein binders
BindCraft: one-shot design of functional protein binders YouTube video by Boston Protein Design and Modeling Club

Have no fear if you weren't in the packed audience this week for @martinpacesa.bsky.social's awesome seminar, because you can check out the recording 👇
youtu.be/qQihl6If9vU

8 months ago 27 9 0 0

Huge congratulations @nboyd.bsky.social with Mosaic that absolutely killed in the competition! 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕2 did also pretty well with the second highest hit rate in the competition!

proteinbase.com/collections/...

2 months ago 29 9 3 1
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Spotlight on the Shingles Vaccine—Again! Two new studies add to a remarkable body of evidence for benefit

Excellent overview of the (mind-blowing) effects of the Shingles vaccine against dementia by @erictopol.bsky.social Ground Truth 🧪 "Two new studies add to a remarkable body of evidence for benefit" ⬇️

open.substack.com/pub/erictopo...

2 months ago 13 7 0 0
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"Not sure if _name_ (my husband) would be ok with this?" - answer from a PI to my suggestion to go to a month-long training outside of country.

3 months ago 3 0 1 0
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What lingers in ‘The Pitt’ is heartache. What’s missing is outrage “I am hungry, so hungry, for some depiction of Covid that tells the truth. That what was done to us was not just unbearable, but wrong,” an emergency physician writes of “The Pitt.”

"If Covid was a fire alarm, our response, incredibly, has been to rip out the wiring. Instead of correcting the underbuilt public health systems that allowed thousands to die in the dark, we are choosing to institutionalize blindness." 👇

www.statnews.com/2026/01/18/t... via @statnews.com

3 months ago 85 33 1 2
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Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis Researchers identified anoctamin-2 (ANO2) as a frequent autoimmune target in multiple sclerosis, with T cell responses against ANO2 occurring in over half of patients. These ANO2-specific T cells shar...

Published in Cell, a new study shows that the immune system’s reaction to the common Epstein-Barr virus can ultimately damage the brain and contribute to multiple sclerosis, from a team @ki.se

www.cell.com/cell/fulltex...

3 months ago 20 8 0 1
Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis Researchers identified anoctamin-2 (ANO2) as a frequent autoimmune target in multiple sclerosis, with T cell responses against ANO2 occurring in over half of patients. These ANO2-specific T cells share cross-reactivity and pathogenic features with T cell responses to EBNA1 from Epstein-Barr virus, and their activation worsens MS-like disease in mice.

3 papers on EBV and MS

Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis

Anoctamin-2 (ANO2) is targeted by T cells in approximately 57% of persons with MS

www.cell.com/cell/fu...
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3 months ago 14 10 1 0
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A new path to spillover: MHC-II entry of influenza A viruses Spillover of influenza A viruses from animals to humans represents a threat to our health. This Perspective discusses emerging research that suggests some influenza A viruses can enter host cells via ...

'But what if IAVs could use a different receptor? Our previous work revealed that the IAV subtypes H17N10 and H18N11, which have so far been detected exclusively in bats, use MHC-II molecules as entry receptors instead of the conventional sialic acid receptors'

3 months ago 24 12 1 0