Shaping the future of cardiometabolic innovation: advances and opportunities - Nature Metabolism Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs, emerging innovations and future needs of therapeutic interventions to counteract obesity and its associated health risks.

#Throwback 🧪

COMMENT | Shaping the future of cardiometabolic innovation: advances and opportunities

@clemmensenc.bsky.social et al

Exercise timing and circadian regulation of metabolism in type 2 diabetes The circadian system regulates daily rhythms in metabolism and hormone secretion; however, in type 2 diabetes, disrupted clock gene oscillations in sk…

Exercise timing and circadian regulation of metabolism in type 2 diabetes.

Our latest review: Exercise modulates our biological rhythms, with timing emerging as an important factor for metabolic outcomes in type 2 diabetes.

www.sciencedirect.com/science/arti...

We recently welcomed two new members to our group @cbmr.science Postdoc Salim Hanna will be working on identifying translation-oriented approaches targeting #AMPK to improve muscle metabolic function. Research assistant, Frederik Gouliaev will be investigating AMPK and its phosphatases in the group.

Metabolism Day 2026 YouTube video by CBMR at the University of Copenhagen

We are just over half way through Metabolism Day 2026, with Dr Manon Mathias now on stage.

Following her talk, the day ends with keynotes from Dr. Antje Körner and Sir Stephen O’Rahilly.

Tune in on the livestream:
www.youtube.com/live/sin5URc...

Metabolism Day strikes again 🔥 Amazing line up of speakers - and fascinating data by Matthias Tschöp to kick off the day!

@cbmr.science

Metabolism Day 2026 is on! Join for free using the below link!

@juleenrzierath.bsky.social kicking off Metabolism Day 2026 #MD26 @cbmr.science

Join in online 👇

www.youtube.com/live/sin5URc...

We are aware of the issue and fixing it now!

Metabolism Day 2026 YouTube video by CBMR at the University of Copenhagen

Tune in to Metabolism Day on our YouTube livestream!

First up is President Matthias H. Tschöp, Professor at Ludwig-Maximilians-Universität München on 'Dual and Triple Co-agonists: From Discovery to Best-In-Class'.

www.youtube.com/live/sin5URc...

Check out this meeting on whole-room indirect calorimetry in Denmark!

Submit your abstract and join international peers to share ideas and spark new collaborations 👇

Free registration: ninaziegenbein.github.io/wricaarhus20...

@stenoaarhus.bsky.social @cbmr.science @zgerharthines.bsky.social

@camillascheele.bsky.social promoted to Professor of Translational Cell Metabolism 🚀

💬"The signaling role of adipose tissue in metabolism is central to understanding cardiometabolic health.”

cbmr.ku.dk/news/2026/th...

The Guasch Group is seeking adults aged 45–70 with an increased risk of cardiovascular disease to participate in a study on sustainable diets and health.

Read more and sign up at planetdiet.dk

If you have any questions, contact the team at planetdiet@sund.ku.dk or +45 93 51 84 39

A big congratulations and thank you for all the marvelous achievements & hardwork to all members of the group. Looking forward for a productive and eventful 2026! Merry Christmas and Happy New Year to everyone from the Sakamoto group @cbmr.science

Diabetogenic processes for insulin resistance-linked hyperinsulinaemia are associated with colorectal cancer - Diabetologia Aims/hypothesis Type 2 diabetes has been associated with increased risk of colorectal cancer (CRC), but the specific diabetogenic pathways contributing to this risk remain unclear. Methods We analysed...

New findings from @CBMR.science show that insulin-resistance-linked hyperinsulinemia is associated with colorectal cancer risk, but not other diabetogenic processes. Largest study yet on this link – led by postdoc Xuan Zhou and @jmerino.bsky.social link.springer.com/article/10.1...

Register now for Metabolism Day 2026! 🚀

The 7th annual conference about cardiometabolic diseases and energy control takes place on March 10, 2026 at @ucph.bsky.social, Denmark.

Attend in-person or watch the live stream.

Read more and register on our website!

eventsignup.ku.dk/metabolismda...

🔔 Excited to teach the PhD course “Bioinformatics Analysis of Gene Expression Data from Bulk RNA-seq” at University of Copenhagen!

📅 26 Jan – 12 Feb 2026

👍 Bring your own data (or use a public one) and learn the full RNA-seq pipeline:

Shaping the future of cardiometabolic innovation: advances and opportunities - Nature Metabolism Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs, emerging innovations and future needs of therapeutic interventions to counteract obesity and its associated health risks.

"#Throwback 🧪

COMMENT | Shaping the future of cardiometabolic innovation: advances and opportunities

@clemmensenc.bsky.social et al

https://bit.ly/4iIBBvY

"We were walking in the streets, chanting 'research for the people, not for profit'" From emergency surgeon to discoverer of GLP-1 and its effects on insulin production and satiety, CBMR Group Leader Professor Jens Juul Holst has spent fifty years pursuing one question: how does metab...

"I think we made a lot of our discoveries because of our tenacity and detective work. We were staying on it and not giving up."

Learn more about CBMR Group Leader Professor Jens Juul Holst and his important role in discovering GLP-1:

cbmr.ku.dk/news/2025/we...

Ancient arctic adaptations may influence modern disease risk Inuit in Greenland possess a unique genome, which has evolved over thousands of years as they adapted to a cold climate and consumed a diet largely consisting of marine mammals. Now, a team of interna...

Read a summary of the findings:

cbmr.ku.dk/news/2025/an...

Genetic regulation of the plasma proteome and its link to cardiometabolic disease in Greenlandic Inuit Circulating proteins play essential roles in complex diseases, yet protein quantitative trait locus (pQTL) studies in non-European, isolated populatio…

Read 'Genetic regulation of the plasma proteome and its link to cardiometabolic disease in Greenlandic Inuit' in the American Journal of Human Genetics. 👉 www.sciencedirect.com/science/arti...

🔹The CPT1A variant is associated with lower levels of 55 inflammatory and cardiovascular proteins in carriers.

🔹 The TBC1D4 variant is associated with altered levels of 9 immune-related proteins.

🔹 Genetic control over protein levels is stronger in Greenlandic Inuit than in Europeans.

Ancient arctic adaptations may influence modern disease risk Inuit in Greenland possess a unique genome, which has evolved over thousands of years as they adapted to a cold climate and consumed a diet largely consisting of marine mammals. Now, a team of interna...

#Inuit genetic adaptations, evolved over 1000s of years as they adapted to a cold climate and consumed a diet largely consisting of marine mammals, influence circulating protein levels in the blood and may modify their risk of diabetes and cardiovascular disease today.

cbmr.ku.dk/news/2025/an...

🌍 Excited to be part of this global effort! 🦠

Microbial and metabolic diversity was mapped across 51 vivaria & 12 wild colonies, revealing striking functional convergence despite taxonomic divergence.

🔗 www.cell.com/cell-host-mi...

The science of weight loss – and why your brain is wired to keep you fat The evolutionary science of weight regain unpacked.

"For decades, we’ve been told that weight loss is a matter of willpower: eat less, move more. But modern science has proven this isn’t actually the case."

@clemmensenc.bsky.social and @johansenvbi.bsky.social in @theconversation.com 👇

theconversation.com/the-science-...

#obesity #metabolism

Framework for the pharmacological treatment of obesity and its complications from the European Association for the Study of Obesity (EASO) - Nature Medicine Obesity and associated complications can be managed by obesity medications, prompting the revision of criteria for the diagnosis and staging of this disease.

A framework from @easoobesity.bsky.social to guide pharmacological treatment of 'fat mass diseases' versus 'sick fat diseases' 👇
www.nature.com/articles/s41...

Stoked to receive this award that will help to dissect the relative contribution of aberrant glycogen levels and impaired glycogenesis in influencing skeletal muscle glucose metabolism.

scDMV: a zero–one inflated beta mixture model for DNA methylation variability with scBS-seq data AbstractMotivation. The utilization of single-cell bisulfite sequencing (scBS-seq) methods allows for precise analysis of DNA methylation patterns at the i

🚨 Dealing with sparse, noisy single-cell DNA methylation data (scBS-seq)? Check out #scDMV.

It uses a zero-one inflated beta mixture model to tackle the excess of 0s/1s and low coverage, boosting accuracy in identifying differentially methylated regions (DMRs).

CBMR's Zach Gerhart-Hines is awarded the first Flemming Quaade Prize for Outstanding Obesity Research for his pioneering discoveries on how fat tissue influences insulin sensitivity, energy expenditure, and appetite control.

Read more: cbmr.ku.dk/news/2025/za...

#obesity #metabolism

Common and distinct roles of AMPKγ isoforms in small-molecule activator-stimulated glucose uptake in mouse skeletal muscle Objective: Small-molecule activators targeting the allosteric drug and metabolite (ADaM) site of AMPK enhance insulin-independent glucose uptake in skeletal muscle and lower glucose in preclinical mod...

Check out our latest preprint from the lab, spearheaded by researcher @itsmedipsikha.bsky.social , investigating the distinctive roles of regulatory gamma subunits of the AMPK protein complex in small molecule activator-stimulated skeletal muscle glucose uptake.
www.biorxiv.org/content/10.1...

Great visit to Novo Nordisk Foundation Center for Genomic Mechanisms of Disease in Boston at Broad Institute. Delighted to see great collaborations with Novo Nordisk Foundation Center for Basic Metabolic Research @cbmr.science @novo-nordisk.bsky.social