New publication @diabetologiajnl.bsky.social led by a fantastic former fellow on our team @hdenroche.bsky.social.
Islet amyloid, long viewed as pathogenic for beta cells, surprisingly disrupts antigen presentation and delays autoimmune diabetes in NOD mice.

Macrophage-toxic bacteria from patients with ulcerative colitis worsen gut inflammation in mice @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

An islet-resident macrophage antioxidant program preserves β cell physiology SLC7A11 licenses metabolic and antioxidant activities in islet macrophages, supporting β cell insulin secretion and redox homeostasis.

A new #ScienceImmunology study finds that mice and humans have pancreatic islet-resident macrophages with elevated antioxidant profiles, which could shield β cells from oxidative stress. https://scim.ag/49cqs3M

An islet-resident macrophage antioxidant program preserves β cell physiology SLC7A11 licenses metabolic and antioxidant activities in islet macrophages, supporting β cell insulin secretion and redox homeostasis.

Very excited to share that our paper on pancreatic islet-resident macrophages is out ! Grateful to contribute to our understanding of these fascinating cells - special thanks to all of our collaborators ! #worlddiabetesday www.science.org/doi/10.1126/...

Schematic of the competitive catabolism model

Excited to share my latest postdoc work on systemic metabolic homeostasis! We show that nutrient consumption fluxes compete, and this competitive catabolism helps explain why obesity drives diabetes. Explore the model with our interactive web app: compcat.princeton.edu

doi.org/10.1101/2025...

Efferocytic remodelling of pancreatic islet macrophages by limited β-cell death - Nature Enrichment for efferocytic macrophages in the islets of Langerhans promotes the accumulation of anergic-like CD4+ T cells and dampens autoimmune diabetes.

Nature research paper: Efferocytic remodelling of pancreatic islet macrophages by limited β-cell death

go.nature.com/476WZqg