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Posts by Camille Keck

Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains one of the deadliest infectious diseases worldwide. Meanwhile, non-tuberculous mycobacteria (NTM) are an increasing global health concern. NTM infections often resemble TB clinically, which can lead to misdiagnosis and inappropriate therapy. Additionally, drug-resistant strains of M. tuberculosis and NTM exacerbate the global antimicrobial resistance crisis. A better understanding of the biology of mycobacterial pathogens and of the mechanisms underlying disease pathogenesis and transmission is critical to reduce their burden worldwide.

This EMBO Workshop is the fourth in a successful series held at the Institut Pasteur in Paris, following the meetings organized in 2012, 2016, and 2022. It will bring together scientists, clinicians, public health experts, and representatives from industry and non-profit organizations, who will share recent insights into mycobacterial infections, from fundamental discoveries to translational research, and their practical implications. The program will cover mycobacterial evolution, physiology, metabolism, host–pathogen interactions, immune responses, mechanisms of drug evasion, therapeutic strategies, vaccines, and diagnostics. Emerging experimental models, computational approaches, and artificial intelligence will also be addressed, showing how recent technologies contribute to advancing mycobacterial research and interventions.

Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains one of the deadliest infectious diseases worldwide. Meanwhile, non-tuberculous mycobacteria (NTM) are an increasing global health concern. NTM infections often resemble TB clinically, which can lead to misdiagnosis and inappropriate therapy. Additionally, drug-resistant strains of M. tuberculosis and NTM exacerbate the global antimicrobial resistance crisis. A better understanding of the biology of mycobacterial pathogens and of the mechanisms underlying disease pathogenesis and transmission is critical to reduce their burden worldwide. This EMBO Workshop is the fourth in a successful series held at the Institut Pasteur in Paris, following the meetings organized in 2012, 2016, and 2022. It will bring together scientists, clinicians, public health experts, and representatives from industry and non-profit organizations, who will share recent insights into mycobacterial infections, from fundamental discoveries to translational research, and their practical implications. The program will cover mycobacterial evolution, physiology, metabolism, host–pathogen interactions, immune responses, mechanisms of drug evasion, therapeutic strategies, vaccines, and diagnostics. Emerging experimental models, computational approaches, and artificial intelligence will also be addressed, showing how recent technologies contribute to advancing mycobacterial research and interventions.

🧬 EMBO Workshop – The complexity of mycobacterial infections: from research to real-world impact

📅 14–18 Sept 2026, Paris

Tuberculosis & non-tuberculous mycobacteria at the heart of discussions: evolution, host–pathogen interactions, drug resistance.

🔗 meetings.embo.org/event/26-myc...

4 weeks ago 8 11 1 0

Let's get ready for a full month of training in image analysis in @pasteur.fr , this summer!

Are you interested in learning how to do bioimage analysis? For light microscopy? for cryo-EM? And for cellular cryo-EM?

Stay tuned, Pasteur offers access to THREE courses, this June.

👇🎓

1 month ago 29 28 3 0

I'm pleased to announce 🍦 Icecream 🍨 v0.3!

New features include:
* Training on multiple tomograms (same training time, with linear increase in RAM) 🚀
* Logging and plotting of the loss function 📉
* The --scale option is now called --eq-weight for clarity 😉

We'd love to hear your feedback! 🙏🏽

5 months ago 14 6 1 1
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Glushkova, Böhm, & Beck @maxplanck.de develop a publicly available computational method to measure the thickness of biological membranes in cryo-electron tomograms. Analysis of algae & human cells reveals systematic membrane thickness variations within & across organelles rupress.org/jcb/article/...

5 months ago 44 12 1 3
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We’re excited to announce the incredible speaker line-up for the Prokaryotic Cell Biology Conference! Join the leading researchers as they explore the latest advances in Nanoimaging, Cell Growth and Cellular Structures.
Join our speakers & register today! ➡️https://bit.ly/47rtkbw
#ProkaryoticCellBio

6 months ago 27 22 1 3
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🧐Checkout our preprint revealing the stepwise firing💥 mechanism of a Contractile Injection System @xujwet.bsky.social&@chipericson.bsky.social trapped the complex by structure-guided engineering🧪 in multiple intermediate states and imaged them by multimodal #cryoEM❄️🔬
www.biorxiv.org/content/10.1...

6 months ago 62 30 1 0
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Postdoctoral position on methanotrophic bacteria - Vacancy at Aarhus University Vacancy at Department of Biology - Microbiology, Aarhus University

I'm recruiting a postdoc to figure out how aerobic methanotrophic bacteria oxidise methane in anoxic freshwater sediment environments: international.au.dk/about/profil... Come to Aarhus University in Denmark and work on this 2-year project funded by @villumfonden.bsky.social!

6 months ago 14 20 0 0
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✨Excited that the main project of my PhD is now available as a pre-print on #bioRxiv

Here, we used #CryoET to visualise mitochondrial proteostatic stress and together with SPA #CryoEM shed light into the functional cycle of the Hsp60:10 chaperone system. #TeamTomo

🔗 www.biorxiv.org/content/10.1...

6 months ago 83 22 2 2
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Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids.
Link: www.biorxiv.org/content/10.1...

7 months ago 54 14 1 2
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Latest from ours: www.cell.com/cell-reports...

This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵

6 months ago 244 101 10 10

Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1 pubmed.ncbi.nlm.nih.gov/41027961/ #cryoEM

6 months ago 3 2 0 0

EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬

The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩‍🔬🤓

6 months ago 58 60 2 4

We will have soon an Open position for a PhD thesis position to work on bacterial secretion systems !

Stay tuned !!

6 months ago 16 12 0 0
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Expanding the genetic toolbox of the obligate predatory bacterium Bdellovibrio bacteriovorus with inducible gene expression and CRISPR interference Inducible gene expression and CRISPR interference-mediated depletion in the predatory bacterium Bdellovibrio bacteriovorus.

🚨New paper out! #MicroSky
Studying obligate predators like Bdellovibrio bacteriovorus is tricky—essential genes for predation are also essential for survival.
We expanded its genetic toolbox:
🧬promoters to fine-tune expression
🧬IPTG-inducible system
🧬CRISPRi for rapid knockdown
bit.ly/46GUn2c
1/4

7 months ago 59 22 2 2
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Cyril Anjou, 2e candidat au prix de thèse nous a présenté ses travaux sur les rôles physiologiques des systèmes thioredoxine de Clostridioides difficile, impliqués dans les étapes du cycle de vie de la bactérie, ainsi que sur l’intérêt thérapeutique potentiel de la modulation de leur expression.🦠

6 months ago 10 6 1 0
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Inorganic sulfate is critical for Mycobacterium tuberculosis lung tissue colonization and redox balance | PNAS Tuberculosis remains the deadliest infectious disease caused by a single pathogen, highlighting the urgent need for novel therapies. A deeper under...

Excited to share Wendy Le Mouëllic’s PhD work, now published in @pnas.org!
It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance.
Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC

6 months ago 64 31 3 1

Time for some insights into our latest #preprint

Using cryo–electron tomography, we peeked inside different #Mtuberculosis strains, and a couple of other mycobacteria.🧐 Surprise: some species, especially the host-adapted ones, build intracytoplasmic membranes (we call them MIMs)! 🦠

6 months ago 8 6 1 0
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Engineering Spatial Control of Bacterial Organelles Bacteria were once thought to lack organelles, but it is now clear they confine cellular reactions using an array of membrane- and protein-based compartments. A central question, however, is how bacte...

New PrePrint from the Vecchiarelli and Mosalaganti (@shyamalm.bsky.social) labs! 🧵

Collaboration with the Giessen and Pi labs

Congratulations to co-first authors Y Hoang (@hoanghamyy.bsky.social) and Pankaj Jadhav!

www.biorxiv.org/content/10.1...

6 months ago 45 25 2 2

Thank you Maite!! 🫶🫶

7 months ago 0 0 0 0
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🌱 Using ‘compelling’ methods, including #CryoET, researchers mapped spinach thylakoid membranes at single-molecule precision, revealing how photosynthetic complexes are organised and settling long-standing debates on chloroplast architecture.
buff.ly/j3TSIkn

7 months ago 67 18 3 7

A molecular-resolution look into the near-native architecture of the spinach chloroplast🌱. This one was a long time in the oven, but we're happy to finally share our "version of record". What long-standing debates did we settle? Check back for a short thread🧵 on Monday. #TeamTomo #PlantScience 🧪🧶🧬🔬🌾

7 months ago 136 46 3 0
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Mycobacterium tuberculosis forms nitrate-induced intracytoplasmic membranes (MIMs) that rewire metabolism & dampen inflammation during infection, uncovering a new layer of bacterial adaptation!
✍️ @camimille.bsky.social @enningalab.bsky.social @pasteur.fr
📖 shorturl.at/9kbDM

7 months ago 5 4 0 0

After years of hard work and months of growing MTB @camimille.bsky.social submitted her story ! Check this out if you wanna discover new intrabacterial structures and their function ! 🦠🔬✨

7 months ago 5 3 0 0
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Serotype swapping in Klebsiella spp. by plug-and-play Understanding how complex, multi-gene systems evolve and function across genetic backgrounds is a central question in molecular evolution. While such systems often impose costs through epistatic inter...

How complex functions, with important physiological and evolutionary impacts get repeatedly and efficiently transferred across genomes?
That’s what we explored using one of the fastest-evolving loci in Bacteria: the capsule locus.
The paper: www.biorxiv.org/content/10.1...
Thread👇

7 months ago 29 22 2 5
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Phenotypic heterogeneity of capsule production across opportunistic pathogens | mBio The polysaccharidic capsule is present in ~50% of species across the bacterial phylogeny, including all ESKAPE microorganisms, the six most significant multidrug-resistant (MDR) nosocomial pathogens. It is also an important virulence factor and a major ...

Delighted to share our recently published work!
Ever wondered how Klebsiella (and others) deals with capsule production’s costs ?
The paper: journals.asm.org/doi/10.1128/...
Thread👇

7 months ago 42 30 2 2
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🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫

Thread coming soon!

7 months ago 32 20 0 3

New preprint from the lab! Great work led by @camimille.bsky.social #mycobacterium #TB #cryoET

7 months ago 6 2 0 0

Happy to share that our story on the bacterial archaellum was published today in @natmicrobiol.nature.com
www.nature.com/articles/s41...

Congrats to the authors: @sshamphavi.bsky.social @loumollat.bsky.social @mariejoest.bsky.social Najwa Taib and @sgribaldo.bsky.social

7 months ago 122 58 7 8
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Tiny Tubes Reveal Clues to the Evolution of Complex Life | Quanta Magazine Scientists have identified tubulin structures in primitive Asgard archea that may have been the precursor of our own cellular skeletons.

Story on our Asgard microtubule paper by Nikki Greenwood: www.quantamagazine.org/tiny-tubes-r...
Thanks to all interviewees🎤

7 months ago 36 13 0 0

Peptidoglycan turnover promotes active transport of protein through the bacterial cell wall www.biorxiv.org/content/10.1101/2025.09....

7 months ago 8 6 0 0