New preprint out 🚀
De novo designed proteins are often too stable — but why?
Using CheMelt, we show that their exceptional thermostability is largely driven by unusually low heat capacity changes (ΔCp).
👉 www.biorxiv.org/content/10.6...
@embl.org @osvalb.bsky.social @proteinmagnus.bsky.social
Photo: O. Jaeckle-Tietjen
Photo: O. Jaeckle-Tietjen
Photo: O. Jaeckle-Tietjen
Last Friday, the President of the Hannover Medical School , Prof. Denise Hilfiker-Kleiner, together with the Vice President of @uni-hamburg.de Prof. Tilo Böhmann visited CSSB.
The visit included tours of PETRA III beamlines as well as CSSB’s four core facilities.
@bosse-lab.bsky.social
Congratulations!
Check out the new @spidocs.bsky.social comic entitled Training the Next Generation SPIDoc‘s: A tale of laser beams and building teams designed by Véro Mischitz.
@leibnizliv.bsky.social @europeanxfel.bsky.social @ebi.embl.org
Very exciting demo on smFRET &FCCS measurements in our SPC facility this week with Exciting Instruments @ei-science.bsky.social ✨🧮
Thank you for allowing us to measure single molecule resolution using your technology.
It has been again, very exciting 🔍🤩
@embl.org @cssbhamburg.bsky.social
Congratulations to the @uni-hamburg.de for once again being awarded the University of Excellence title! 🎉
Universität Hamburg gewinnt Exzellenztitel erneut 👏 Damit erhält die UHH weiterhin als eine von wenigen Universitäten diese bedeutende Förderung. Künftig liegt der Fokus noch stärker auf der Twin Transformation, die Nachhaltigkeit und Digitalisierung als Querschnittsaufgabe verbindet: uhh.de/n87ie
Hello BlueSky Community, do you know of any European Cryo-EM facility which possess a High-pressure freezer being used under BSL-2 safety level? The sample would be a bacterial biofilm.
Happy International Women's Day! #IWD2026
CSSB supports women in science and we pledge to
elevate & celebrate women’s achievements.
@carobarisch.bsky.social, @landaulabcssb.bsky.social
@topf-lab.bsky.social, @mariarosenthal.bsky.social
Today’s CSSB @cssbhamburg.bsky.social Seminar Series featured Paul Guichard @centriolelab.bsky.social from Geneva who shared their beautiful discoveries of the centriole assembly, conoid molecular architecture, and the connecting cilium of the eye! ♡ 🫧 @uni-hamburg.de
Such a fun collaboration with @mel-foulon.bsky.social from the TS lab 🤝-👀 We combined dual RNA-Seq 🧬 and advanced imaging 🔬 to uncover how intracellular compartmentalization drives niche-specific metabolic phenotypes in mycobacteria!!
Fantastic team effort ✨
#Tbsky #microsky
Course 'Ion trap and advanced MS techniques' - group picture at MS Vision
The year has just started, a lot already happened at SPIDocs!
🎉Charlotte Uetrecht - new Scientific Director @cssbhamburg.bsky.social
🚀Secondments at @uppsalauniversity.bsky.social and Fasmatech Science and Technology
🚀Internships at SLAC
✨Course 'Ion trap and advanced MS techniques' at MSVision
New preprint from @carobarisch.bsky.social lab!
@mariarosenthal.bsky.social
#STEM #GirlsInScience
🎉 Happy International Day of Women and Girls in Science 🔬
Some of our group leaders shared insights into what they love most about their jobs in science. ❤️
CSSB supports women and girls in science through initiatives like Girls‘ and Boys‘ Day.
#WomenInScience @landaulabcssb.bsky.social
Integrated structural biology at its best with fantastic talks in cryo-EM, NMR, and X-ray techniques
Also integration with other Instruct Centres, in this case Kay Grünewald Instruct-DE @cssbhamburg.bsky.social 'Conformational flexibility and molecular plasticity in herpesvirus entry and egress'
New protocol out now! 📕🖊️🔍
A practical workflow for analyzing CD thermal unfolding of short RNAs — from SVD decomposition to two-state fitting to extract melting temp and enthalpy with ChiraKit.
A must-see if you’re working with RNA structure and CD data.
DOI: 10.1007/978-1-0716-5084-4_12 
My colleagues have put together a nice book chapter on amyloid polymorphism. Have a look! 🧪🧬🧶
#amyloids #cryoem @landaulabcssb.bsky.social @meytallandau.bsky.social @cssbhamburg.bsky.social @stratifa.bsky.social
Fun in the snow!
New Year, New Leadership!
Charlotte Uetrecht is the new Scientific Director of CSSB. Holger Sondermann and Tim Gilberger are Deputy Directors.
Find out more: t1p.de/q6mdg
@carobarisch.bsky.social @topf-lab.bsky.social @landaulabcssb.bsky.social @bosse-lab.bsky.social @jankosinski.bsky.social
Wishing you peace, joy and happiness this holiday season. Looking forward to 2026!
@leibnizliv.bsky.social @fzborstel.bsky.social @helmholtzhzi.bsky.social @embl.org @uni-hamburg.de
The 25th issue of our CSSB Connect newsletter is here!
Find out what's been going on at CSSB during the second half of 2025.
t1p.de/352cr
@uni-hamburg.de @leibnizliv.bsky.social @fzborstel.bsky.social @helmholtzhzi.bsky.social @embl.org
Our next CSSB Connect newsletter is coming out soon!
Make sure it's delivered straight to your inbox by signing up today: t1p.de/hnamq
@landaulabcssb.bsky.social @carobarisch.bsky.social @bosse-lab.bsky.social @topf-lab.bsky.social @jankosinski.bsky.social
Congratulations Julia!
Congrats to Thomas Mulvaney from the @topf-lab.bsky.social for his Nomination for the Leibniz Association’s Dissertation Award — a great recognition of his innovative work on integrative modeling of proteins and nucleic acids. #ResearchExcellence
@leibnizliv.bsky.social
@cssbhamburg.bsky.social
MHH invites applications for a W1 university professorship for Systems Virology at CSSB. The research focus should be on analyzing viral infections using innovative, systemwide methods to elucidate virus-virus and virus-host interaction networks.
More info: t1p.de/nag2v
@bosse-lab.bsky.social
CSSB group leader Jens Bosse @bosse-lab.bsky.social @resist-cluster.bsky.social and CSSB associate member Chris Meier @uni-hamburg.de , together with Hans-Achim Wagenknecht from the Karlsruhe Institute of Technology, have developed a new method for live-cell RNA imaging
Find out more: t1p.de/18suk
The Krey lab is hiring! If you are interested in viral glycoproteins, neutralizing antibodies and vaccines - and you want to further study this using structural and biochemical approaches, please apply!
stellenangebote.uni-luebeck.de/jobposting/d...
Join CSSB! The Sondermann lab is interested in deciphering the molecular processes that determine bacterial interactions in microbial communities. They are looking for a PhD candidate to investigate the bacterial secretion systems involved in these processes.
Apply now: v22.desy.de/e67416/recor...
