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Posts by Nicolas Rivron

@nicolasrivron.bsky.social and I look to recruit a postdoc through the VIP3 rogramme to investigate post-implantation development of blastoids.

Contact us if you are interested, and let your colleagues who could be interested know!

1 week ago 3 1 0 0

I'm now on Bluesky!🤗 Excited to share our preprint, reviving
Kristy Red-Horse's interest in the placenta from her PhD ~20 years ago! We find using 3D imaging that the mouse placenta is far more invasive than previously thought. Furthermore, we find a surprise from our favorite chemokine CXCL12...🧵:

1 week ago 11 2 2 2

Hi all! 👋
leeboratory.bsky.social and I are recruiting a VIP³ postdoc to join our teams and decode the genetic logic of how blastoids transit to the post-implantation stage. MolBio, genetics and computational approaches. If this sounds like you (or someone you know), we’d love to hear from you! 🚀

1 week ago 11 10 0 1
A guide to using embedded ethics in human stem-cell-based embryo model research - Nature Cell Biology This Perspective proposes the use of an integrative embedded ethics approach to evaluate human stem-cell-based embryo models and outlines a nested benchmarking strategy to periodically evaluate their scientific and ethical status.

📣 New Perspective out in @natcellbio.nature.com! With an interdisciplinary team of scientists, ethicists & lawyer we propose embedded ethics as a framework for navigating the complex ethics of human stem cell–based embryo models.

www.nature.com/articles/s41...

Free full text link: rdcu.be/fckmY

🧵

1 week ago 37 12 1 0
Morally relevant features warranting ethical oversight in human stem cell-based embryo models Nature Cell Biology - This Perspective presents a set of attributes by which to evaluate human stem cell-based embryo models that not only include morally relevant embryo features but also take...

Following several years (!) of discussion and rumination, our team of excellent colleagues - Martin Pera, @nicolasrivron.bsky.social, @amartinezarias.bsky.social, Karen Sermon and Nienke de Graeff - have published a new ethical perspective on SCBEM #embryomodels rdcu.be/fcklG [1/5]

1 week ago 29 11 1 0

Watson was deeply influential to me as a genomicist, but not how you may assume

From stealing Rosalind Franklin's lab notes to his frequent sexist & racist bioessentialist comments later in life, he showed how the scientific community would still worship a terrible person

Don't idolize bad people

5 months ago 359 87 4 5
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Conservation and alteration of mammalian striatal interneurons - Nature An analysis of cell-type diversity in brain samples from a variety of mammalian species, both during development and in adult animals, reveals that the TAC3 initial class of striatal interneurons is c...

Our new manuscript, led by Emily Corrigan, examines inhibitory neuron diversity across approximately 160 million years of evolutionary divergence, as part of BRAIN Initiative Cell Atlas Network (BICAN) developing brain atlas package: www.nature.com/articles/s41...

5 months ago 60 22 2 1
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Complexity without ethics: Why integration matters for embryo models | PET Properly understood, the integrated/non-integrated distinction was not just a technical shorthand for the presence or absence of particular tissues.

The ethical framework for embryo models needs clarity and simplicity. The spirit of the integrated/non-integrated distinction was to more prominently regulate models that could potentially develop into a fetus. Hafez Ismaili M’hamdi discusses this. www.progress.org.uk/complexity-w...

6 months ago 6 2 1 1

Thrilled to announce that I am looking for a Research Technician/Assistant to join my lab @imbavienna.bsky.social. Please consider applying if you’re enthusiastic about #devbio #stemcells #teamwork and excited to help shaping a new lab!

Thankful for any retweet! 🫶

imba.onlyfy.jobs/job/l6u2m980

1 year ago 50 41 1 3

Join us in Vienna! The line-up of speakers is ready!

1 year ago 4 0 0 0
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Congratulations to Theresa Sommer on the completion of her PhD! Theresa, a researcher in the Nicolas Rivron Group, presented her work on “Developing a stem cell – based 3D model of the human blastocyst and its application in exploring mammalian embryo morphologies” at her PhD defense.

1 year ago 15 2 0 0
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A genome-wide atlas of human cell morphology - Nature Methods An optical pooled cell profiling platform (PERISCOPE) based on Cell Painting and optical sequencing of molecular barcodes was used to develop the first unbiased genome-wide morphology-based perturbati...

Our paper “A genome-wide atlas of human cell morphology” is finally out today in @naturemethods.bsky.social ! www.nature.com/articles/s41...

(I tweeted about our preprint in 2023 over at the bad place, but deactivated my account, so here we go again!)

1 year ago 138 39 2 2
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1/3 Embryogenesis requires fit cells. Here, following work from @miguel-torres-1963.bsky.social & @tristanrodriguez72.bsky.social and led by @joshifrenster.bsky.social we develop a #gastruloid model of #CellCompetition
www.biorxiv.org/content/10.1...
showing it recapitulates much of the embryo 🧵

1 year ago 48 11 1 1
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The mobile genome: genetic and physiological impacts of transposable elements

Dear all, registrations are open for the Mobile Genome @EMBO workshop. Many slots for posters, short talks but also long talks for last minute groundbreaking results! Let’s meet again on Nov 4-7, 2025 in Heidelberg. www.embl.org/about/info/c...

1 year ago 47 40 0 0
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We are #hiring! Join GMI as the new Operation Engineer and supervise the technical, economic support and maintenance of the buildings. #europe #jobs #science https://imba.onlyfy.jobs/job/2fow0g5m

1 year ago 3 2 0 0
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We are hiring! Join IMBA as the new Operation Engineer and supervise the technical, economic support and maintenance of the buildings. #europe #jobs #science https://imba.onlyfy.jobs/job/2fow0g5m

1 year ago 3 2 0 0
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BMAL1 is a critical regulator of sex-specific gene expression in the heart Pieterjan Dierickx; BMAL1 is a critical regulator of sex-specific gene expression in the heart, Function, , zqaf004, https://doi.org/10.1093/function/zqaf0

Check out our Perspective on a new @kaesser.bsky.social lab study showing that the circadian clock protein BMAL modulates sex-specific differences in both rhythmic and non-rhythmic cardiac gene expression: academic.oup.com/function/adv...
Original paper: academic.oup.com/function/adv...
@dzhk.de

1 year ago 5 3 0 0
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I’m very excited about this collaborative project! We managed to significantly scale up and streamline human blastoid generation without the use of feeders. @leeboratory.bsky.social @grazianomartello.bsky.social @pasquelab.bsky.social and Nicolas Rivron @ucph.bsky.social

1 year ago 17 2 0 0
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With pleasure we share our preprint reporting robust and cost-effective expansion of naive human Pluripotent Stem Cells without feeder cells. A fantastic collaborative effort with @leeboratory.bsky.social @jzylicz.bsky.social @pasquelab.bsky.social and Nicolas Rivron.

tinyurl.com/5n6z9rt9

1 year ago 54 16 3 6
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Feeder-free culture of naive human pluripotent stem cells retaining embryonic, extraembryonic and blastoid generation potential Conventional human pluripotent stem cells (hPSCs) are widely used to study early embryonic development, generate somatic cells, and model diseases, with differentiation potential aligned to a post-imp...

Exciting community effort for robust feeder-free maintenance of human naive pluripotent stem cells with blastoid formation potential. Collaboration with @grazianomartello.bsky.social, @leeboratory.bsky.social @jzylicz.bsky.social @nicolasrivron.bsky.social tinyurl.com/5n6z9rt9

1 year ago 24 4 3 0

A pleasure for Emiel Van Genderen and myself to be able to contribute to this study that helps build solid foundations for conscientious modeling of human development through robust and efficient protocols. Doing science together with such people is a privilege. Thanks @grazianomartello.bsky.social

1 year ago 1 0 0 0

We are happy to contribute to this exemplary collaborative study aimed at improving the efficiency of working with human naïve ESCs without MEF feeder cells. With @grazianomartello.bsky.social‬, @jzylicz.bsky.social, @pasquelab.bsky.social, and @nicolasrivron.bsky.social
tinyurl.com/5n6z9rt9

1 year ago 7 1 0 0
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The deadline to submit your abstract for a talk at the 2025 SY-Stem Symposium has been extended to January 22, 2025. Registration deadline remains on February 15th. For more details and to submit your abstract, visit: www.sy-stem.org
We hope to see you there!

#SYStem2025

1 year ago 7 5 0 1

Join us in Vienna! A symposium dedicated to young scientists doing stem cell research with most talks by First authors in the transition to independent positions!

1 year ago 1 1 0 0
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Scanning electron microscope image of a human trunk-like structure (left) and human embryo (right) false coloured for somites (magenta) and neural tube (gold).

Scanning electron microscope image of a human trunk-like structure (left) and human embryo (right) false coloured for somites (magenta) and neural tube (gold).

Have you ever wondered how your back formed? The human embryo makes a neural tube (future spinal cord) and somites (trunk muscle/bone) from ~d20. They’re formed at the same time and place, so we used human Trunk-like Structures (hTLS) to investigate their ‘co-development’… (1/7)

1 year ago 80 28 3 3
Photo of Human Technopole

Photo of Human Technopole

Thrilled & immensely honoured to receive the Italian Science Fund (FIS) Starting Grant. We will uncover the mechanisms underlying HSV-1 latency and reactivation in human, disease relevant, cells.

Postdoc positions in virology and human stem cell biology @humantechnopole.bsky.social available soon!

1 year ago 52 6 8 1
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The ISSCR invites all students and postdoc members to create their own session at #ISSCR2025! Choose your own topic and showcase recent developments and scientific breakthroughs that you’re passionate about. Learn more 👉 bit.ly/3Op2MxB

1 year ago 4 3 0 0
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I'm speaking at ISSCR 2025 Annual Meeting, join me Register now

Happy New Year! I look forward to the #ISSCR2025 annual meeting in Hong Kong and hope to see you there to talk about how to use #blastoids and all other stem cell based embryo models to make important scientific and medical discoveries! invt.io/1txbejpdn2u
@isscr.org

1 year ago 6 2 0 0