Weichhart Lab (@weichhartlab) Bsky

Aspartate availability drives differential engagement of the malate-aspartate shuttle Brunner et al. report that malate-aspartate shuttle engagement is cell-state dependent and can be modulated by the availability of the amino acid aspartate. In differentiated cells, malate-aspartate s...

A big chunk of my postdoctoral work on cell-state dependent metabolism is now out at @cp-molcell.bsky.social: www.cell.com/molecular-ce... 1/

1 month ago 29 15 2 3

Home – UNLIMITED – A Marie Skłodowska-Curie Actions Doctoral Networks (MSCA-DN) funded by the European Union

The @immunometeurope.bsky.social al is looking for PhD students in an @horizoneu.bsky.social funded consortium: UNderstanding Lipid ImmunoMetabolIsm To trEat Disease. Apply here: www.unimedizin-mainz.de/unlimited-ms...

2 months ago 1 0 0 0

Thanks @weichhartlab.bsky.social and @preprintclub.bsky.social !

2 months ago 4 2 0 0

O-GlcNAcylation shapes macrophage tissue residency and alternative activation Nature Reviews Immunology - A preprint by Heieis et al. shows that O-GlcNAcylation regulates the alternative activation of macrophages and their tissue residency through effects on cell cycle and...

Amitava Sinha & @weichhartlab.bsky.social from @preprintclub.bsky.social discuss a @biorxiv-immuno.bsky.social #preprint by Heieis et al. that identifies O-GlcNAcylation as a metabolic regulator of cell cycle, enabling macrophage tissue-residency and IL-4-driven alternative activation

2 months ago 6 2 1 3

Aged mice exhibit widespread metabolic changes but preserved major fluxes Metabolic dysregulation is a hallmark of aging, but how metabolic pathway activity (flux) changes with age has yet to be broadly assessed. Here, Jankowski et al. measure metabolite concentrations and ...

Aging 🧓 alters metabolite levels, but not core metabolic fluxes!
Impressive work from @sfb_immunomet postdoc Connor Jankowski (PhD thesis) just out in Cell Metabolism 👏
#Aging #Metabolism #Fluxomics
🔗 www.cell.com/cell-metabol...

5 months ago 0 0 0 0

Drs. José Carlos Alves Filho, Luciana Berod (@luberod.bsky.social), and Thomas Weichhart (@weichhartlab.bsky.social) are presenting their work on the metabolic regulation of immune responses at #IUIS2025!

Check out the session at 1:45 pm in Hall E1.

8 months ago 10 5 0 0

Some big news: I’ve been awarded an ERC Advanced Grant to further explore the roles of #archaea in gut #microbiomes and beyond.
@erc.europa.eu
#ERCAdG #ARCHMETH #Microbiome #Archaea #sciencepassion

10 months ago 81 5 7 1

Ein Screenshot eines Mobiltelefons

Neues aus der Mikrobiom-Forschung!
Archaeen – kaum bekannte Mitbewohner in unserem Darm – senden winzige Bläschen, um mit ihrer Umwelt zu kommunizieren.
Ein Team der Med Uni Graz hat das jetzt erstmals detailliert beschrieben. Veröffentlicht in Nature Communications ➡️ https://bit.ly/47gnl9R

8 months ago 14 4 0 0

Paul Ettel receives FSR Early Career Fellowship Grant | MedUni Vienna

and here is the press release from the university: www.meduniwien.ac.at/web/en/ueber...

9 months ago 1 0 0 0

Paul Ettel, MD-PhD student in the lab has been awarded a prestigious Early Career Fellowship Grant from the Foundation for Sarcoidosis Research (FSR). FSR will support Paul’s research on the role of neutrophils and arginine metabolism in granuloma formation in sarcoidosis. Congratulations!

9 months ago 6 1 1 0

We are grateful to the Austrian Science Fund @fwf-at.bsky.social for receicing a new standalone grant to study metabolic signaling in sarcoidosis!

9 months ago 2 0 0 0

The immunometabolic topography of tuberculosis granulomas governs cellular organization and bacterial control Despite being heavily infiltrated by immune cells, tuberculosis (TB) granulomas often subvert the host response to Mycobacterium tuberculosis (Mtb) infection and support bacterial persistence. We previously discovered that human TB granulomas are enriched for immunosuppressive factors typically associated with tumor-immune evasion, raising the intriguing possibility that they promote tolerance to infection. In this study, our goal was to identify the prime drivers for establishing this tolerogenic niche and to determine if the magnitude of this response correlates with bacterial persistence. To do this, we conducted a multimodal spatial analysis of 52 granulomas from 16 non-human primates (NHP) who were infected with low dose Mtb for 9-12 weeks. Notably, each granuloma’s bacterial burden was individually quantified allowing us to directly ask how granuloma spatial structure and function relate to infection control. We found that a universal feature of TB granulomas was partitioning of the myeloid core into two distinct metabolic environments, one of which is hypoxic. This hypoxic environment associated with pathologic immune cell states, dysfunctional cellular organization of the granuloma, and a near-complete blockade of lymphocyte infiltration that would be required for a successful host response. The extent of these hypoxia-associated features correlated with worsened bacterial burden. We conclude that hypoxia governs immune cell state and organization within granulomas and is a potent driver of subverted immunity during TB. ### Competing Interest Statement M.A. and S.B. are named inventors on patent US20150287578A1, which covers the mass spectrometry approach utilized by MIBI-TOF to detect elemental reporters in tissue using secondary ion mass spectrometry. M.A. and S.B. are board member and shareholder in IonPath, which develops and manufactures the commercial MIBI-TOF platform.

Preprint can be found here: www.biorxiv.org/content/10.1...

9 months ago 1 0 0 0

Spatial immunometabolic zonation in tuberculosis granulomas - Nature Reviews Immunology A preprint by McCaffrey and Delmastro et al. delineates distinct immunometabolic zones of tuberculosis granulomas and reports that hypoxia is a key driver of immune subversion.

Amitava Sinha via the @preprintclub.bsky.social‬ wrote a nice Journal Club article on a preprint by from the Angelo lab @stanfordmedicine.bsky.social that describes spatial immunometabolic zonation in tuberculosis granulomas: www.nature.com/articles/s41...

9 months ago 6 2 1 0

Anne Miller erhält FWF-ASTRA-Preis Mehr über ihre Forschungsarbeit!

Ausgezeichnet für ihre Forschungen zum #Zellstoffwechsel 💯

Wir gratulieren Anne Miller, Zentrum für Pathobiochemie und #Genetik der #MedUniWien, zur Auszeichnung mit dem FWF-ASTRA-Preis! Mehr über ihre Arbeit erfahren ⬇️

@fwf-at.bsky.social

9 months ago 15 3 0 1

Special thanks goes to the amazing SFB immunometabolism, which made this work possible, and of course the extraordinary, phantastic MEL team.

10 months ago 3 1 0 0

Supported by @microbesplanet.bsky.social
@medunigraz.at @fwf-at.bsky.social - Thank you!

10 months ago 4 1 1 0

📢 Big day for archaeal microbiology!

Today, we jointly shed light on the mysterious world of archaeal extracellular vesicles from human gut archaea - published in @natcomms.nature.com ‬ in parallel with our precious colleagues around @mkrupovic.bsky.social 🇦🇹🤝🇫🇷.

10 months ago 32 21 1 1

#msca #industry #business #marieskłodowskacurieactions #unionofskills… | Marie Skłodowska-Curie Actions Strengthening Europe’s research and innovation capacity also means investing in its researcher’s long-term careers. This is precisely the goal of the #MSCA…

www.linkedin.com/posts/mscact...

1 year ago 8 3 0 0

Proud to announce that we are one of the 149 out of 1417 successful applicants to be funded for a EU MSCA Doctoral Network! Looking forward to this big challenge coordinaring such an amazing network: UNLIMITED (UNderstanding Lipid ImmunoMetabolIsm To trEat Disease)

1 year ago 10 4 2 0

Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression @cp-immunity.bsky.social
www.cell.com/immunity/ful...

1 year ago 21 9 1 0

Posts by Weichhart Lab