#resilience2025 fantastic speaker line-up: Andrew Holmes, Moh Milad, Dominique de Quervain @dequervain.bsky.social, Birgit Kleim, Rose Bagot @rcbagot.bsky.social, Floris Klumpers, Patricia Molina @pmolinamolina.bsky.social, Marianne Müller, Penny Lewis, Niels Niethard @nniethard.bsky.social, ...

With a slight delay, we turned this awesome paper into a comic 😍 Sneak peek below, check out the full version here: tinyurl.com/3jajehbn

@mathiasvschmidt.bsky.social @joeribordes.bsky.social
#neuroskyence #scicomm #wisskomm #sciart

Congratulations to the three winners of the Junior Investigators Awards: Pegah Kassraian, @joeribordes.bsky.social, and Laura Meine!

Keep up the great work!

@univbordeaux.bsky.social @columbiauniversity.bsky.social

#earlylifestress #memory #stress #stressnetworkch #SN2025

7) This work wouldn't have been possible without the contributions of the co-authors. Also a special thanks goes to the DeepLabCut development team www.mackenziemathislab.org/deeplabcut

And if you would like to use DeepOF check here:

deepof.readthedocs.io/en/latest/

6) 🌟 Conclusion:

ELS impacts stress-related neurobiology differently in males & females.
HPA-axis dysregulation, altered fear memory, & brain metabolism may inform sex-specific interventions for stress-related disorders.
Check out the full study for details!

5) Brain metabolism alterations by ELS:

ELS altered purine & glutamate metabolism pathways in the BLA, dHIP, & vHIP.

Sex differences in these pathways might explain distinct behavioral outcomes.

Linking brain metabolism to stress response is key!

4) 🚀 Using the open-source package DeepOF, we performed unsupervised analysis of fear behaviors. This revealed novel sex-specific patterns, in which females showed more active fear response (darting-like behavior) via explorative behaviors, that males did not show.

3) 🔍 Fear memory formation is altered on freezing:

ELS exposure reduces freezing behavior during fear retrieval especially in males.

2) 🧬 We show that ELS affects HPA-axis regulation differently in males & females:

Females: Persistent body weight effects & elevated baseline CORT early on

Males: Altered adrenal weight & delayed recovery of HPA-axis function

Sex matters in stress response!

1) Early life stress (ELS) increases vulnerability to stress-related disorders, such as PTSD, often with sex-specific impacts. Using a mouse model, we explored how ELS alters:
- HPA-axis regulation
- Fear memory acquisition & retrieval using
- Brain metabolomic pathways

Sex-specific fear acquisition following early life stress is linked to amygdala and hippocampal purine and glutamate metabolism - Communications Biology This study models early life stress (ELS) to observe sex-specific effects on fear memory formation using innovative unsupervised classification together with cellular metabolism alterations in key str...

We've uncovered sex-specific effects of early-life stress (ELS) exposure on fear memory, HPA-axis regulation, and brain metabolism🧠. Unsupervised clustering shows that fear responses are more than only freezing.
@mathiasvschmidt.bsky.social
nature.com/articles/s42...
Highlights in thread👇

Deep phenotyping reveals CRH and FKBP51-dependent behavioral profiles following chronic social stress exposure in male mice - Neuropsychopharmacology Neuropsychopharmacology - Deep phenotyping reveals CRH and FKBP51-dependent behavioral profiles following chronic social stress exposure in male mice

New paper from the lab, where we show how the co-chaperone and psychiatric risk factor FKBP5 acts in CRH-expressing neurons to shape stress- sensitive social behavior. Deep phenotyping using #DLC and #DeepOF was key to unravel these effects. www.nature.com/articles/s41...