jonny (good kind) (@jonny@neuromatch.social) Attached: 1 image reminder that anthropic ran (and is still running) an ENTIRE AD CAMPAIGN around "Claude code is written with claude code" and after the source was leaked that has got to be the funn...

jonny over on masto doing god's work:

> anthropic [is running] an ENTIRE AD CAMPAIGN around "Claude code is written with claude code" and after the source was leaked that has got to be the funniest self-own in the history of advertising because OH BOY IT SHOWS.

neuromatch.social/@jonny/11632...

I wonder how much of it is due to other local pressures. Eg Bedfordshire (Tempsford) is growing at 3x the national average already. This *badly* shows up in NHS amongst other things, plus the East of England is in a water debt as it's the driest bit of the country. (Out of drought as of today!)

On Friday we revealed the Companies House vulnerability letting anyone access the private dashboard of any UK company.

This is the moment I first saw it demonstrated. My reaction says it all.

What do we know? What don't we know? What should companies do now?

We do need to replace it with something better than what we have right now though, which is a bung to your mate or the person who "donated" £100k to your party!

I like the idea of a considerably longer term elected chamber. Long enough that the members aren't swayed by fashion.

Hereditary peers to be removed from Lords as bill passes The bill abolishes the 92 seats reserved for peers who inherit their titles through their families.

At last! All remaining hereditary peers in the UK House of Lords will go in May

92 men, mostly old, will no longer have a significant voice in our governance simply due to *who their parents were*, usually based on a forgotten deed by a long, long dead ancestor

www.bbc.co.uk/news/article...

woke up

Can we at least agree that endless layers of management consultants and "architects" may perhaps just be fluffing their own egos and selling snake oil?

It appears to be a corporate disease that goes in fashion waves.

Certain types of sea urchins will pick up a shell with their tube feet and ‘wear’ it, with a behavior known as “covering reaction”, mainly because they shy away from light. So aquarium enthusiasts 3D-printed tiny hats and they actually wear them.

nobel prize. right fucking now. im serious.

Climate crisis: We’ve filed our challenge to Starmer’s delay | Good Law Project Global heating is all around us and the government isn’t doing enough – so we’re taking them to court

⚖️🌎 BIG NEWS THIS WEEK 🌍⚖️
https://goodlaw.social/kxzk

GitHub - markmoxon/the-sentinel-source-code-bbc-micro: Fully documented and annotated source code for The Sentinel on the BBC Micro Fully documented and annotated source code for The Sentinel on the BBC Micro - markmoxon/the-sentinel-source-code-bbc-micro

I am delighted to announce the release of my latest project:

Fully documented source code for The Sentinel, Geoff Crammond’s 1986 masterpiece.

Here’s the repository; deep dives coming soon.

See thread for details.

1/9

github.com/markmoxon/th...

#retrocomputing #retrogaming #bbcmicro #c64 #8bit

Happy New Year Kavey

UK ministers urged to cap political donations to ‘rebuild voter confidence’ Letter from 19 organisations says a cap would help to protect democracy, weeks after £9m donation to Reform UK

How about we get rid of political donors all together?
Ban the wealthy elite from owning UK politicians.

Dressed in a Santa suit with snowflakes falling a jolly old elf wrangles a Dune sandworm. (ed. note: meme swiped from @SoDakTruth on Twitter)

@funranium.bsky.social
Always be stealing Dune memes!

SAMtools / HTSLib / BCFTools 1.23 has been released. See the releasenotes on GitHub and www.htslib.org for details.

The usual process ofbuilding modern C++ packages from GitHub...

Step 1: download and build yet another new version of cmake.

Bah Humbug. (I tried edited it and no, it did indeed need some new feature. Sigh) I miss the old ways.

A lovely collection of fungi from WildlifeTrustBCN's Gamlingay Woods. #fungi

Never forget: At breakneck speed we are leaving the stable Holocene climate in which human society developed and thrived. Weather extremes are outside historical experience. Sea-level rise is accelerating. Dangerous tipping points are ahead.
Graph: ed-hawkins.github.io/climate-visu...

Spot on with printers though. Satanic devices, and clearly the subject of Rage Against The Machine.

A feeling of dirtiness, a sense of horror, verging on revulsion. So maybe it's a perfect fit for VCF? 🤣

My gut feeling is we'd be better just having a JSON equivalent to VCF than JSON inside VCF. (Eg if we wanted JSON, then the whole of info should be json, not just each element.)

I hear you wish -S. It's not so much that it's not needed, it doesn't harm, but that it's typically indicative of out of date information still doing the rounds/

My pet peeve is "samtools view -b foo.sam > foo.bam" instead of "-o". It causes lots of confusion with nohup and similar.

I've heard that before too, but the naming of it predates my involvement so I've no idea if it stood for anything. It's plausible, but *shrug*.

It's curious to see grokipedia is up and has samtools, SAM and BAM pages all with a flurry of edits. Oddly, most of those edits are correcting minor edits in the Wikipedia pages it based its content on (presumably via some AI rewriting tool).

A shame the originals weren't edited too.

Efficient and accurate search in petabase-scale sequence repositories - Nature MetaGraph enables scalable indexing of large sets of DNA, RNA or protein sequences using annotated de Bruijn graphs.

The Metagraph paper is out in Nature; it showed up in my feeds today! Congratulations to Mikhail Karasikov, @gxxxr.bsky.social, @akkah21.bsky.social and all of the other authors (whom I'd love to follow on Bluesky if I can find you ;P) www.nature.com/articles/s41...

You can't out reform Reform. They're loony conspiracy theory nutters - you shouldn't *want* to woo them!

We need parties that accept why the economy has tanked and will take steps to fix it. Leaving the ECM - Common Market - was the dumbiest idea ever (regardless of how you voted on Brexit).

"OpenZL is our answer to the tension between the performance of format-specific compressors and the maintenance simplicity of a single executable binary."
engineering.fb.com/2025/10/06/d...

A complete diploid human genome benchmark for personalized genomics Human genome resequencing typically involves mapping reads to a reference genome to call variants; however, this approach suffers from both technical and reference biases, leaving many duplicated and ...

Delighted to finally announce a preprint describing the Q100 project! “A complete diploid human genome benchmark for personalized genomics” For which we finished HG002 to near-perfect accuracy: www.biorxiv.org/content/10.1... 🧵[1/14]

Note: OLD POST! (2023), but I just noticed it.

While it's nice to see comparisons, why compare an (at the time) 2 year old GATK against a 5 year old bcftools?

Since then both have come on a lot. It'd be interesting to see new independent comparisons. (Neither can hold up to deepvariant now.)

I noted in their presentation they said that samtools mpileup didn't work. I think they're a bit out of date. Bcftools mpileup --poly-mqual can handle the qualities in homopolymers, plus other newer -X profiles.

I haven't tuned it yet though for SBX, but think it'll be OK in general. (To try!)

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I'm sorry, worldwide, irrevocable, non-exclusive, transferable permission to my voice and likeness? For what now? In any manner for any purpose???

This is in academia/.edu's new ToS, which you're prompted to agree to on login. Anyway I'll be jumping ship. You can find my stuff at hcommons.org.

Instagram is like facebork but even more annoying. I looked and I can't even find the equivalent post for you over there. It's just a hateful platform. Probably OK for doom scrolling on a phone, but that's about it.