Interorgan crosstalk typically occurs via the bloodstream. We showed that brain-heart-gut interplay also occurs in their electrophysiology at infra-slow timescales. We found that fluctuations in the gut are typically followed by the brain and heart after tens of seconds.
doi.org/10.64898/202...

Comparative anatomy of brain metabolism in human and macaque (and other species). The dichotomy between glucose as fuel and glucose for tissue building is conserved across species. @moohebatpe.bsky.social and @misicbata.bsky.social

www.biorxiv.org/content/10.6...

The complete morphology of a single LC-NE neuron.

First off, these cells are gigantic. This one, for example, has >72 cm of axon! To our knowledge, it’s the longest neuron ever fully reconstructed. I leave it to the reader as an exercise to estimate the length of a human LC neuron. 5

Delighted to share our discoveries about one of the brain's neurotransmitter systems:
www.biorxiv.org/content/10.6...

Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1

Using simulations, we investigated whether Value-Shaping imitation was always a good thing. And it's not (or is it ?? *gasp*) 🧵

‘The Brain, In Theory,’ an excerpt In his new book, Brette pushes back against theories that describe the brain as a “biological computer.” In this excerpt from Chapter 4, he challenges equating brain evolution with programming…

"The Brain, In Theory" is out today!

A short excerpt in The Transmitter @thetransmitter.bsky.social

www.thetransmitter.org/theoretical-...

Wanna do neuroscience in Paris but can't find interesting lab?

Want to come do a sabbatical but don't know who to collaborate?

Check this webpage aggregating ~all the neuroscience labs (+200) in Paris.

⚠️only the information of 'verified' profiles is reliable⚠️

Please retweet 🙏

parisneuro.fr

Opportunities and pitfalls of data contextualization in neuroimaging - Nature Reviews Neuroscience Despite rapid exploitation of the opportunities that contextualization of brain maps affords, potential limitations have received little attention. In this Roadmap, Royer et al. provide practical guid...

Correlating brain maps across datasets is everywhere in neuroimaging. Here we ask: when you contextualize a brain map against genes, metabolism, or connectivity... What can you really conclude? How can we do better? We explore these questions here: tinyurl.com/2dudkevc

Acetylcholine demixes heterogeneous dopamine signals for learning and moving Nature Neuroscience - Jang et al. measured dopamine and acetylcholine release in the striatum of rats performing a decision-making task and found that the relative timing of cholinergic and...

Thrilled to share our new paper, which shows that the relative timing of cholinergic and dopamine release dynamically gates whether dopamine acts as an RPE for in vivo plasticity and reinforcement learning. www.nature.com/articles/s41...

🧠What if increasing neuronal firing could actually reduce fMRI connectivity?
📡What drives long-range fMRI connectivity?

I’m very excited to share that my PhD work is now out as a preprint
Check this out! 👇
doi.org/10.64898/202...

Curious about how brain and body communicate, or how circuit states are regulated over seconds to hours? Read our paper about neuropeptide systems and how they contribute to neural architecture and function

#neuroskyence #compneuro #neuroscience

Competitive interactions shape mammalian brain network dynamics and computation - Nature Neuroscience Brain network architecture may balance cooperation and competition across circuits. Here the authors use computational whole-brain modeling across three species to show that models with competition ar...

Just out in @natneuro.nature.com! 🧠

“Competitive interactions shape mammalian brain network dynamics and computation”
www.nature.com/articles/s41...

Is large-scale brain communication purely cooperative — or is competition a core organizing principle?

We built 🧠 models to find out: read on🧵👇

Spatial organization of AQP4 channels in the human brain: links with perfusion, edema, and disease vulnerability | doi.org/10.64898/202...

Aquaporins are a key component of the brain’s glymphatic system. How are they distributed and how do they relate to healthy brain function and dysfunction? ⤵️

Synaptome architecture shapes regional dynamics in the mouse brain | doi.org/10.1371/jour...

How do diverse synapses relate to the spatial patterning of whole-brain dynamics? Justine Hansen explores @plosbiology.org ⤵️

🚀 We are hiring: a PhD position is available in my lab (gozzilab.it) at @iitalk.bsky.social, Italy. Project: large-scale brain network mapping in behaving mice using functional ultrasound imaging (FUSI).
📅 Deadline: March 31
🔗 tinyurl.com/4jtetxa9
Reshares appreciated 😊

Excited to introduce ScaRCaMP — a highly blue-light resistant red GECI. 🔴

Now live on bioRxiv and marking my first PhD preprint (2nd for the Marko lab).

Would love feedback from the community!!

Linking neural manifolds to circuit structure in recurrent networks Dimensionality reduction methods are widely used in neuroscience to investigate two complementary aspects of neural activity: the distribution of sing…

Excited to share our new paper to be published in Neuron!

With Valentin Schmutz @bio-emergent.bsky.social and Wulfram Gerstner @gerstnerlab.bsky.social, we explore how circuit structure in RNNs shapes network computation and single-neuron responses.
www.sciencedirect.com/science/arti...

Once you get past the first 5 minutes of me bumbling around clearly in need of media training, we settle into a nice groove talking about fitting mechanistic models, ML/AI for neuroscience, underconstrainedness vs. degeneracy, and its potential benefits for biology (plus some good chuckles).

fMRI connectivity is dominated by recurring high-amplitude BOLD events (CAPs, QPPs)
But what originates these events? Many think neuromodulation is the culprit. Our new work offers a simpler take: cortico-cortical dynamics alone can generate CAP-like events! doi.org/10.1371/journal.pcbi.1013995
🧵1/n

Spatial organization of AQP4 channels in the human brain: links with perfusion, edema, and disease vulnerability www.biorxiv.org/content/10.64898/2026.02...

🚨Do we need a large, expensive MRI scanner to map whole-brain networks in the mouse? Not necessarily!

In our new preprint ▶️ tinyurl.com/3a2h4r9f
we show that transcranial functional ultrasound (fUSI) can map connectome-scale networks with striking agreement to fMRI
🧵👇

We're hiring! This is a unique opportunity to translate our understanding of neural computation - from circuit-level mechanisms to computational principles - into the human brain, through the establishment of cutting-edge human neural recording capabilities with collaborators in London and abroad.

We’re hiring a Group Leader!

Join us to lead a transformative initiative in human systems neuroscience.

Find out more and apply ⤵️

www.sainsburywellcome.org/content/curr...

Inter-individual variability of neurotransmitter receptor and transporter density in the human brain | doi.org/10.1007/s004...

How do neuroreceptor distributions vary across people?

Left: Pathways involved in brain energy metabolism. Energy metabolism refers to processes involved in energy production from nutrient molecules. Glucose is the main energy source in the brain under normal physiological conditions. Glucose entering brain cells can be utilized in three parallel pathways. It can be processed through glycolysis to produce 2 ATP and 2 pyruvate molecules (blue). Lactate dehydrogenases catalyze the interconversion of lactate and pyruvate (purple). Pyruvate is transported into mitochondria, where it enters the TCA cycle to generate high-energy electron carriers NADH and FADH2 (green), driving the complete oxidation of glucose through the mitochondrial electron transport chain (red). Glucose entering the brain can also enter the PPP. PPP is an anabolic pathway that uses glucose to produce 5-carbon sugars and NADPH, an essential co-factor used in nucleotide and lipid biosynthesis (yellow). Glucose can also be stored in the form of glycogen via glycogen synthase, a process mainly active in astrocytes. Right: Energy pathway maps. Colors show z-scored mean expression values across all genes in each pathway. ppp, pentose phosphate pathway; tca, tricarboxylic acid cycle; oxphos, oxidative phosphorylation; lactate, lactate metabolism and transport.

How are energy #metabolism pathways distributed across the #cortex? @alaindagher.bsky.social &co map five pathways in the human #brain, linking metabolic organization with brain structural & functional properties, as well as developmental dynamics @plosbiology.org 🧪 plos.io/4c1JVp8

Convergent transcriptomic and connectomic controllers of information integration and its anaesthetic breakdown across mammalian brains - Nature Human Behaviour Luppi et al. identify transcriptomic and connectomic controllers of information integration and its breakdown induced by anaesthesia in humans, macaques, marmosets and mice.

Luppi et al. identify transcriptomic and connectomic controllers of information integration and its breakdown induced by anaesthesia across species

netneurotools: a trainee-oriented approach to network neuroscience | doi.org/10.1101/2025...

Our lab’s internal toolkit for accomplishing everyday tasks in brain imaging ⤵️

BOLD signal changes can oppose oxygen metabolism across the human cortex, Nature Neuroscience

fMRI signals “up,” but neural metabolism might be going “down.”

In our @natneuro.nature.com paper, we demonstrate that about 40% of voxels with robust BOLD responses exhibit opposite oxygen metabolism, revealing two distinct hemodynamic modes.

rdcu.be/eUPO8
funds @erc.europa.eu
#neuroskyence 🧵:

It's happening! Canada launched two programs to recruit international researchers.

Canada Impact+ Research Chairs (1 million/yr for 8 yrs +)
Canada Impact+ Emerging Leaders.

I will do my best to facilitate the process for those interested. Hit me up.

www.canada.ca/en/impact-pl...

Cognitive cartography of mammalian brains using meta-analysis of AI experts The complexity of the brain is increasingly mirrored by the complexity of the neuroscientific literature, yet no individual mind can fully grasp the diversity of scales, methodologies and model organi...

🧠 Excited to share our latest preprint: Automated Brain Mapping with AI Experts!🤖

www.biorxiv.org/content/10.6...

Ever wanted to summarise the cognitive/systems neuroscience literature beyond MRI and PET? Ever wished we could do the same for macaque 🐒 and mouse 🐭 ? Read on! 🧵👇

The Transmitter’s Rising Stars of Neuroscience 2025 We recognize the outstanding achievements of 25 neuroscientists who stand to shape the field for years to come.

Truly honored to be recognized among @thetransmitter.bsky.social's Rising Stars of Neuroscience for 2025 next to trailblazers like @valeriejsydnor.bsky.social, @lindenmp.bsky.social, @elimuller.bsky.social & more!🌟🧠Check out everyone's full contributions at www.thetransmitter.org/early-career...