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Advanced breast cancer patients living longer thanks to improvements in treatment and care - ecancer ecancer.org/en/news/2722... #ABClisbon
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Spanish report on research presented at #ABClisbon - Cáncer de mama metastásico: la supervivencia aumenta hasta siete meses www.infosalus.com/salud-invest...
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Portuguese report on study of survival times for advanced #BreastCancer patients presented at #ABClisbon - Pacientes com câncer de mama avançado vivem mais tempo graças a melhorias no tratamento e nos cuidados portalenf.com/2025/11/paci...
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Advanced breast cancer patients living longer thanks to improvements in treatment and care, according to researh by Fatima Cardoso & Thibaut Sanglier presented at #ABClisbon www.ricemasonnoble.eu/2025/11/06/a...
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WTF is this “non special type”????? So ductal, the most common type isn’t special?? As @hoperugo points out, this can be offensive to patients. #ABCLisbon
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In IBC biomarkers are needed - in locally advanced or nonmetastatic IBC biomarkers should include ER, PR, HER2, Ki67, BRCA 1/2. In mIBC, biomarkers should be ER, PR, HER2, PDL1 in TNBC, PIK3CA in ER+/HER2-, BRCA1/2 #86.6% agree #ABCLisbon
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I’m glad @ClaireMyerson spoke up (as a person with MBC) to say that it, like everything else, is ultimately the patient’s decision!!! #ABCLisbon
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Current discussion about pregnancy after ABC diagnosis and a LOT of discussion about phrasing “patient and her partner’s preference” - it is the PATIENT’S decision - body autonomy people!!!!!!! #ABCLisbon
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Aaarrrggghhhh! Live stream isn’t pulling up on my phone so I can’t screenshot slides! #ABCLisbon
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What about TDXd? There have been cases of fatal ILD and this probably should include a statement on close CT monitoring for ILD. This risk should be clearly communicated to patients & need to report immediately.
This is all part of shared decision making. #ABCLisbon
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Vote is in favor of SG BUT the PFS benefit and cost aren’t much different than elacestrant and OS is only 3.2 mo (albeit in heavily pretreated). There definitkey seem to be some biases here. #ABCLisbon
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Capivasertib will likely be approved in the 🇺🇸 shortly. @hoperugo points out that the discussion about cost/benefit ration of elacestrant appears biased if the same isn’t made here - we don’t know the cost of capi yet but it sure as 💩 isn’t going to be cheap. #ABCLisbon
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Should elacestrant be recommended? Vote before discussion is split. @hoperugo asks, what else do we do, what about patient preference for an oral
option w/ fewer AES than an ADC??? And those who got 24+ months on CDK had 8 mo ⬆️ PFS. I’m with Hope on this one. #ABCLisbon
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If CDK4/6i + ET is recommended as first line why would we change this as maintenance after response to chemo, but what about SONIA…..??? Vote on 1st is 42% no, on 2nd (either option ok) #mis 75% yes #ABCLisbon
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Based on SONIA is it ok to use endocrine therapy alone 1st line? Or given data on ⬆️ OS a with ribo and abema should those + ET be the recommended 1st line. As a person who got 6 years on just an AI I say we need biomarkers of who will do well with just ET!!! #ABCLisbon
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Should long term responders be able to take a treatment holiday? @FallowfieldLJ points out that some patients may think it’s ok to stop treatment here and there without letting their onc know. @MammaMiaMagazin reminds the panel that there are time and 💰reasons too. #ABCLisbon
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It is 😭 that we have to have a statement about what to do in cases of war and conflict. It’s not just the people who die in war, and cancer patients who die because of lack of treatment access during war, but also those who will die yes later because of delayed dx/tx #ABCLisbon
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What about surgery on the primary tumor?? A LOT of discussion about removing the bullet on oligometastatic and rewording the last bullet to reflect this means all the mets but not 1° tumor disappear with systemic treatment. 97.6% finally agree!!
This is so fun!!!
#ABCLisbon
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What to do with oligometastatic disease? @FallowfieldLJ thinks it might be hard to recruit patients to a trial but @DrEricWiner points out the damages of bone marrow transplant that was recommended back in the day without evidence! Going to skip vote to revise #ABCLisbon
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Ooohhh, let’s see what they say about oligometastatic disease (sorry, can’t get that “unmute” off the screen). 100% agreement: without data ablation of oligometastatic outside the brain can’t be universally recommended. We need trials!!!! #ABCLisbon
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New this time is discussion of HER2-low. Dr @hoperugo points out out there is no definition -or data- on HER2 ultra low,
so it will be removed. 94.5% agree with this definition, minus the ultra low sentence. #ABCLisbon
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Dr @DrEricWiner sets the stage for today’s consensus session at #ABCLisbon, by reviewing definitions. There will be a manuscript published with all of this plus the recommendations.
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So excited for the consensus session at #ABCLisbon. It is the most fascinating thing to watch the world’s experts like my onc Dr @hoperugo (& #advocates @ClaireMyerson @MammaMiaMagazin @IBCResearch ) debate the best, most evidence based treatments for particular circumstances.
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Dr Volkmar Mueller’s webinar was on leptomeningeal disease (which is way understudied because most #ClinicalTrials exclude LMD).
Prognosis is poor, treatments are
limited, and what data there is not specific to MBC. #ABCLisbon
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There is only 1 randomized prospective trial in ER+ visceral crisis (but so bad as to need immediate chemo) that showed that ribo + endocrine therapy was basically the same as chemo #ABCLisbon
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Because #ClinicalTrials only want the “cancer Olympians” there really isn’t great data on what to do or dose modifications to use #ABCLisbon
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Dr @hoperugo reports on a webinar on visceral crisis - important point: visceral mets like liver or lung in and of itself is NOT crisis - there has to be significant organ dysfunction and it does NOT mean chemo is the only option. #ABCLisbon
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