Microglial APOE3 Christchurch protects neurons from Tau pathology in a human iPSC-based model of Alzheimer’s disease Sun et al. demonstrate that APOE3 Christchurch microglia protect neurons from Aβ-induced Tau pathology by regulating lipid peroxidation and phagocytosis. Targeting APOE and lipid metabolism in microgl...

Scientists from @cityofhope.bsky.social , @ucimind.bsky.social , & @udea.bsky.social used neuron-microglia co-cultures & neuroimmune #organoids from #hiPSCs to discover why a certain genetic variant, #APOECh, can delay AD progression. In @cp-cellreports.bsky.social

www.cell.com/cell-reports...