Experimental Insights and Recommendations for Successfully Performing Cerebral Microdialysis With Hydrophobic Drug Candidates Cerebral microdialysis in rodents represents a robust and versatile technique for quantifying the pharmacologically relevant unbound fraction of drugs in the brain. When this unbound fraction is simu...

Paper on the challenges of hydrophobic drugs in cerebral microdialysis accepted to #CTSJournal, #ASCPTJournalFamily Based on own data + intensive literature review, we developed a decision tree to guide future studies in testing unspecific binding prior to microdialysis: doi.org/10.1111/cts....