🚀From Bench to Paper | Targeting #ATF4 in Elderly #KRAS #LungCancer
Age reshapes tumors: slows growth but boosts metastasis via integrated stress response. ATF4 drives plasticity; targeting ISR-ATF4 blocks spread&exposes glutamine vulnerability. High ATF4 links to poor survival—promising target.

🦵 Just published online in JPS❣️
"ATF4 Transcriptionally Activates NUPR1 to Promote Ferroptosis in Chondrocytes and Osteoarthritis Development"
-- Chen Kuang et al.
🔗 [https://doi.org/10.1016/j.jphyss.2025.100039]
#Osteoarthritis #Ferroptosis #ATF4 #NUPR1 #NowOnline #JPhysiolSci