More work however needs to be done on how we assess frailty in the ICU, the biological underpinnings, and how we can improve outcomes. Hopefully there’ll be more studies in the future for us to hear about at next year’s ATS! (10/10) 🧵 The End

#ECPromo2025 #ats2025 #ATSCritCareLive

Dr. John Muscedere reviewed that frailty is common- prevalence in the ICU is around 22-37%. He suggests the best interventions to address frailty can be remembered by the acronym AVOID: activity, vaccination, optimization of meds, interaction, and diet (nutrition). (9/10)
#ats2025 #ATSCritCareLive

Dr. Nathan Brummel cautions against using frailty to decide if critical care should be recommended, as we could be conflating the impact of acute illness with frailty. 🚧 (8/10)

#ECPromo2025 #ats2025 #ATSCritCareLive

What can we do about frailty then in the ICU? Here's a guide! 👇 (7/10)

#ECPromo2025 #ats2025 #ATSCritCareLive

Not all frailty is the same. There are physical, psychological, and social domains and we need to address the right domain. For the physical domains, there are multiple pathways and fortunately exercise and nutrition benefit most of these pathways! 💪 (6/10)

#ECPromo2025 #ats2025 #ATSCritCareLive

Dr. Jon Singer shared some good news- frailty is treatable! Most interventions for frailty focus on exercise +/- nutrition and on a group level, these improve frailty. 🏋️‍♀️ 🥬 However, exercise and diet require behavior change, which can be challenging. (5/10)

#ECPromo2025 #ats2025 #ATSCritCareLive

Dr. Eleanor Kate Phillips discussed that frailty is a state of disrupted homeostasis. In chronic frailty, many genes are overrepresented, especially in immune response. 🦠 (4/10)

#ECPromo2025 #ats2025 #ATSCritCareLive

Despite this, in a review of critical care interventions, only one RCT had subgroup data for frailty! Given its impact on outcomes, Dr. Ferrante suggests we add frailty to our pre-specified subgroup analyses to our RCTs. 📊 (3/10)

#ECPromo2025 #ats2025 #ATSCritCareLive

Dr. Lauren Ferrante shared data showing that frailty is associated with worse in-hospital and long-term mortality. It’s also associated with worse QOL for patients. (2/10)

#ECPromo2025 #ats2025 #ATSCritCareLive

We heard some excellent talks this morning at ATS on frailty, and we’re here to give you some of the key takeaways! A thread 🧵 (1/10)

@atsearlycareer @ATS_Assemblies @atscommunity
#ats2025 #ATSCritCareLive #ECPromo2025