#AcuteSinusitis

Graphs comparing Amoxicillin-Clavulanate vs. Amoxicillin for acute sinusitis in adults, published online April 18, 2026. Figure 3 shows cumulative incidence curves for treatment failure, new antibiotic use, & adverse events after propensity score matching.

Among adults with #AcuteSinusitis, standard-dose amoxicillin-clavulanate did not reduce treatment failure compared with amoxicillin, while overall failure and hospitalization rates were low in both groups.

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Graphs comparing Amoxicillin-Clavulanate vs. Amoxicillin for acute sinusitis in adults, published online April 18, 2026. Figure 3 shows cumulative incidence curves for treatment failure, new antibiotic use, & adverse events after propensity score matching.

Presented at #ESCMIDGlobal2026: Among adults with #AcuteSinusitis, standard-dose amoxicillin-clavulanate did not reduce treatment failure compared with amoxicillin, while overall failure and hospitalization rates were low in both groups.

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🔥Nationwide retrospective study supporting standard-dose amoxicillin vs. amoxicillin-clavulanate as preferred empiric treatment for adults with uncomplicated acutevsinusitis without recent antibiotic exposure when antibiotics are indicated #AcuteSinusitis @jama.com

Cumulative incidence curves comparing amoxicillin-clavulanate to amoxicillin for acute sinusitis in adults. Graphs display treatment failure, new antibiotic use (with and without outpatient encounters), and antibiotic-associated adverse events over 14 days.

Among adults with #AcuteSinusitis, standard-dose amoxicillin-clavulanate did not reduce treatment failure compared with amoxicillin, while overall failure and hospitalization rates were low in both groups.

#ESCMIDGlobal2026 @escmid.bsky.social

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