Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer’s disease - Nature Communications Succinylation is a metabolism-associated post-translational protein modification. Here the authors describe changes to the succinylation of proteins in the brain of individuals with Alzheimer’s diseas...

A study shows that a chemical modification succinylation alters the behavior of #APP & #Tau linked to #Alzheimers. These changes promote toxic aggregation, contributing to plaque & tangle formation in the #brain.

The #researchers used our #BetaAmyloid 1–42 #AggregationKit t.ly/QtHwQ

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Age-associated microglial transcriptome leads to diminished immunogenicity and dysregulation of MCT4 and P2RY12/P2RY13 related functions - Cell Death Discovery Cell Death Discovery - Age-associated microglial transcriptome leads to diminished immunogenicity and dysregulation of MCT4 and P2RY12/P2RY13 related functions

#Researchers explored the differential immune responses of aged versus young microglial cells. To investigate the role of Amyloid-Beta in these processes, they utilized rPeptide’s #BetaAmyloid 1-42 #AggregationKit to prepare and treat cells ahead of phagocytosis assays.

t.ly/2GGAM

BA: t.ly/qtpHs